Definition Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession NC_005823
Length 4,277,185

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The map label for this gene is cya [H]

Identifier: 45656791

GI number: 45656791

Start: 1085410

End: 1086813

Strand: Direct

Name: cya [H]

Synonym: LIC10900

Alternate gene names: 45656791

Gene position: 1085410-1086813 (Clockwise)

Preceding gene: 45656777

Following gene: 45656792

Centisome position: 25.38

GC content: 35.33

Gene sequence:

>1404_bases
ATGAATTCATTGCTCAATCTATATAACTGGAATATCCGCCAAAAATTAATGGTGATCATTTCGATTATCATTCTTATCTC
TTTAGGAACAATCATCGCTCTCGCTACATATTTTTTCAAATCGGATAACGAAATTCGTGTTAAAGAAAATAACTTGAAAC
TGACGGACGTAATTAGTCAAAAAATACGTTCGGATATTGCCTCTTTGACAAAACGTTCTCTGCTTCTTGCTCGGTCTATG
GCGGATTCGGAGGAATCTAGCGATATTTTACAAAACGACGACGATATTTTTTATCTGAAAATTTTCAGAAAAGAAGGTTC
TGATTACGTAGGCGTAAAACGAATCATTGATGAACGTACTCTAAAAGACTTTAAAGTTAGTTCGGATAACGCGGATAAAA
TTGTACGTAAATATTTAAACGGACAAAAAAAGGCTCAGCTCGGAAAACCTCTCGTATTTAACGTATCACCCGATTTTCGT
AGGCCGGTATTGTATCTTTCCATTTTTGTAGGAGACAAAAACAATTCGGCAATACTCGTTTCTTTGGTAAAAATGGATTC
TATATTAGATTCTTTTAAAACATCCGGAATCACACAATTTTTTCTAGTAGGAAATGATGGAGCTCTAATCGCACATTCCG
ATTCTAAATTGATTTTACAACCTACCGATCTTAAAGACGAACCGATTGTTAAAAATTTATTAGAAAGTGCAATCAGTAAT
GGACAAACTCGCTACAAAGGAAAGGACGATCAATATTATTTAGGTTCTTTTAGAAGAATCGGATACGCTGGACTTGGAGT
AATTTCTAGTACTTCTGAAAAGAAAGCGTTTGAAGAAGTTTATAATATTCAAAAAAGAAATATTTATCTGATGATCGTAG
TGGTAAACGTTTCTATATTATTTGTATTTTTTTATGCAAGAAGACTGACAAGACCAATACTTAAACTTGTGGACGCTTCC
AAACAAATCGAACAGGGAAACTTTCATATAGATCTCAAACCGGAGTCAGGAGACGAAATTGGAAGACTCACTTCTTCCTT
TGTCGAAATGGGAAAAGGTTTATCCGATCGAGATAAAATGAAGGACGCATTCGGAAAATTTGTCAACAAAGACATTGCGG
AAATGGTTCTACGAGGAGAAGTAAAACTAGGAGGAGATAAAAGGGAATGTGTGATTTTATTTTCTGATATTCGTAACTTC
ACTTCTATCTCGGAAAAAATTGAACCGGAATTAGTCGTAGAATTTTTAAATCAGTATTTTACTGCAATGGTAAAGTGTAT
TAACGAAAACGGAGGAAGCGTCAATAAATATATAGGAGACGCTATTATGGCCGTTTGGGGGGGAATTGGGACATACGAAT
TCCGACACGGAAAGATCGATTTTGGCCGCGTTGGATATGCGTAA

Upstream 100 bases:

>100_bases
AACTTTCTATAAAATCAATTTGTAAAATAGTGTTGTTTTATAAATTCAATTGAATGTAATAGACTCTTTGATCGGATAAC
AAAACTCGAACGGAAACGTT

Downstream 100 bases:

>100_bases
GAGTTTGATACAATTCAACAAAGGAAGAGGGAGTGATAAAAAACCAAAAATATTTATCGGGATTGGAATCAATACGGGAG
AAGTCATTGCGGGTCAAATC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNSLLNLYNWNIRQKLMVIISIIILISLGTIIALATYFFKSDNEIRVKENNLKLTDVISQKIRSDIASLTKRSLLLARSM
ADSEESSDILQNDDDIFYLKIFRKEGSDYVGVKRIIDERTLKDFKVSSDNADKIVRKYLNGQKKAQLGKPLVFNVSPDFR
RPVLYLSIFVGDKNNSAILVSLVKMDSILDSFKTSGITQFFLVGNDGALIAHSDSKLILQPTDLKDEPIVKNLLESAISN
GQTRYKGKDDQYYLGSFRRIGYAGLGVISSTSEKKAFEEVYNIQKRNIYLMIVVVNVSILFVFFYARRLTRPILKLVDAS
KQIEQGNFHIDLKPESGDEIGRLTSSFVEMGKGLSDRDKMKDAFGKFVNKDIAEMVLRGEVKLGGDKRECVILFSDIRNF
TSISEKIEPELVVEFLNQYFTAMVKCINENGGSVNKYIGDAIMAVWGGIGTYEFRHGKIDFGRVGYA

Sequences:

>Translated_467_residues
MNSLLNLYNWNIRQKLMVIISIIILISLGTIIALATYFFKSDNEIRVKENNLKLTDVISQKIRSDIASLTKRSLLLARSM
ADSEESSDILQNDDDIFYLKIFRKEGSDYVGVKRIIDERTLKDFKVSSDNADKIVRKYLNGQKKAQLGKPLVFNVSPDFR
RPVLYLSIFVGDKNNSAILVSLVKMDSILDSFKTSGITQFFLVGNDGALIAHSDSKLILQPTDLKDEPIVKNLLESAISN
GQTRYKGKDDQYYLGSFRRIGYAGLGVISSTSEKKAFEEVYNIQKRNIYLMIVVVNVSILFVFFYARRLTRPILKLVDAS
KQIEQGNFHIDLKPESGDEIGRLTSSFVEMGKGLSDRDKMKDAFGKFVNKDIAEMVLRGEVKLGGDKRECVILFSDIRNF
TSISEKIEPELVVEFLNQYFTAMVKCINENGGSVNKYIGDAIMAVWGGIGTYEFRHGKIDFGRVGYA
>Mature_467_residues
MNSLLNLYNWNIRQKLMVIISIIILISLGTIIALATYFFKSDNEIRVKENNLKLTDVISQKIRSDIASLTKRSLLLARSM
ADSEESSDILQNDDDIFYLKIFRKEGSDYVGVKRIIDERTLKDFKVSSDNADKIVRKYLNGQKKAQLGKPLVFNVSPDFR
RPVLYLSIFVGDKNNSAILVSLVKMDSILDSFKTSGITQFFLVGNDGALIAHSDSKLILQPTDLKDEPIVKNLLESAISN
GQTRYKGKDDQYYLGSFRRIGYAGLGVISSTSEKKAFEEVYNIQKRNIYLMIVVVNVSILFVFFYARRLTRPILKLVDAS
KQIEQGNFHIDLKPESGDEIGRLTSSFVEMGKGLSDRDKMKDAFGKFVNKDIAEMVLRGEVKLGGDKRECVILFSDIRNF
TSISEKIEPELVVEFLNQYFTAMVKCINENGGSVNKYIGDAIMAVWGGIGTYEFRHGKIDFGRVGYA

Specific function: May function as a membrane-localized receptor protein [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 52772; Mature: 52772

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLLNLYNWNIRQKLMVIISIIILISLGTIIALATYFFKSDNEIRVKENNLKLTDVISQ
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
KIRSDIASLTKRSLLLARSMADSEESSDILQNDDDIFYLKIFRKEGSDYVGVKRIIDERT
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
LKDFKVSSDNADKIVRKYLNGQKKAQLGKPLVFNVSPDFRRPVLYLSIFVGDKNNSAILV
HHHCCCCCCCHHHHHHHHHCCCHHHHCCCCEEEECCCCCCCCEEEEEEEEECCCCCEEEE
SLVKMDSILDSFKTSGITQFFLVGNDGALIAHSDSKLILQPTDLKDEPIVKNLLESAISN
EHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCC
GQTRYKGKDDQYYLGSFRRIGYAGLGVISSTSEKKAFEEVYNIQKRNIYLMIVVVNVSIL
CCEECCCCCCCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHHHHHHH
FVFFYARRLTRPILKLVDASKQIEQGNFHIDLKPESGDEIGRLTSSFVEMGKGLSDRDKM
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHH
KDAFGKFVNKDIAEMVLRGEVKLGGDKRECVILFSDIRNFTSISEKIEPELVVEFLNQYF
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHH
TAMVKCINENGGSVNKYIGDAIMAVWGGIGTYEFRHGKIDFGRVGYA
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNSLLNLYNWNIRQKLMVIISIIILISLGTIIALATYFFKSDNEIRVKENNLKLTDVISQ
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
KIRSDIASLTKRSLLLARSMADSEESSDILQNDDDIFYLKIFRKEGSDYVGVKRIIDERT
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
LKDFKVSSDNADKIVRKYLNGQKKAQLGKPLVFNVSPDFRRPVLYLSIFVGDKNNSAILV
HHHCCCCCCCHHHHHHHHHCCCHHHHCCCCEEEECCCCCCCCEEEEEEEEECCCCCEEEE
SLVKMDSILDSFKTSGITQFFLVGNDGALIAHSDSKLILQPTDLKDEPIVKNLLESAISN
EHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCC
GQTRYKGKDDQYYLGSFRRIGYAGLGVISSTSEKKAFEEVYNIQKRNIYLMIVVVNVSIL
CCEECCCCCCCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHHHHHHH
FVFFYARRLTRPILKLVDASKQIEQGNFHIDLKPESGDEIGRLTSSFVEMGKGLSDRDKM
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHH
KDAFGKFVNKDIAEMVLRGEVKLGGDKRECVILFSDIRNFTSISEKIEPELVVEFLNQYF
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHH
TAMVKCINENGGSVNKYIGDAIMAVWGGIGTYEFRHGKIDFGRVGYA
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7601856 [H]