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The map label for this gene is dapA

Identifier: 45656733

GI number: 45656733

Start: 1021594

End: 1022517

Strand: Direct

Name: dapA

Synonym: LIC10842

Alternate gene names: 45656733

Gene position: 1021594-1022517 (Clockwise)

Preceding gene: 45656731

Following gene: 45656734

Centisome position: 23.88

GC content: 40.8

Gene sequence:

>924_bases
TTGATTGCCAAATCCGGCTCAAATCAAGAATCTAACCCTATGTTCCAGGGCGTTTATACGGCGATCATCACACCATTCAA
AAACGATAAAATCGATTACGACAGTTATTTCAAACTACTGGAAAAACAAATCAAAGCCGGAGTCAGTGGAGTTGTTCCTT
GTGGAACGACTGGAGAATCTCCGACTCTTTCTCATAGTGAACACGCGGAACTGATTCGAGAAACTGTCAAAGCAGTACAA
GGAAAAATTCAAGTAGTGGCTGGAACTGGGTCCAATTCTACAAAAGAAGCGATCGAATTGACAGAGGCGGCTTGTAAAGA
TGGAGTGGATGGAATTCTTTCCGTAAATCCTTATTATAATAAACCAACACAAGAAGGACTCTTTCAACATTTTAAATCAA
TTGCAGAACATTCTACCGTACCAGTGATGCTCTACAATATTCCTGGAAGAACTTCCGTAAATTTATTACCGGAAACCGTA
CTCAGGCTTAGTGAGGTCAAACAGATTCGATCTATGAAAGAGGCCACGGGAGATCTGGGACAAATGGGGAAATTAATTTC
CTTAGTGGGAAATAAAATGACTGTACTTTCCGGGGACGATAACTTGACCCTTCCCTTACTTGCAATCGGAGGAGTAGGGG
TTGTGTCCGTGATTTCCAATTTATTTCCAAAAGCTTTAGTACAACTTGTAGAATCGTTTCAACAGGGAAAAATCTCCGAG
GCCAAAAAAATACATTATGATTTTATTGAAGTCTTTGCACTTGCTTTTATGGAAACCAACCCGATACCAATCAAGGCGGC
GATGTGCTGGTTTGGTCATTGTGGTCCGGAAATACGACTTCCGTTGACTCCACTTTCTCAAAACGAGACAAGTTCTAAAT
TTAAAAAGGTGCTCGAAGGTCTGAAAGAAAAAGGATACGAATAG

Upstream 100 bases:

>100_bases
AGCACACGTAAATACTGGATTCCAGAAAAAAGAAATCTGTTTCACTAGCAATCCAGACTAGAAGTAAGAAGTCTCACTGC
AATCAGAAATCGAAACGTTT

Downstream 100 bases:

>100_bases
AGAATGAGTCAACCTTCAAAAACTCAAATCGCTTTGATCGGAGCGTCCGGAAGAATGGGGCGCGCCATTGTCTCCGTACT
TTCTACTTCTGTTAAATCCA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MIAKSGSNQESNPMFQGVYTAIITPFKNDKIDYDSYFKLLEKQIKAGVSGVVPCGTTGESPTLSHSEHAELIRETVKAVQ
GKIQVVAGTGSNSTKEAIELTEAACKDGVDGILSVNPYYNKPTQEGLFQHFKSIAEHSTVPVMLYNIPGRTSVNLLPETV
LRLSEVKQIRSMKEATGDLGQMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVISNLFPKALVQLVESFQQGKISE
AKKIHYDFIEVFALAFMETNPIPIKAAMCWFGHCGPEIRLPLTPLSQNETSSKFKKVLEGLKEKGYE

Sequences:

>Translated_307_residues
MIAKSGSNQESNPMFQGVYTAIITPFKNDKIDYDSYFKLLEKQIKAGVSGVVPCGTTGESPTLSHSEHAELIRETVKAVQ
GKIQVVAGTGSNSTKEAIELTEAACKDGVDGILSVNPYYNKPTQEGLFQHFKSIAEHSTVPVMLYNIPGRTSVNLLPETV
LRLSEVKQIRSMKEATGDLGQMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVISNLFPKALVQLVESFQQGKISE
AKKIHYDFIEVFALAFMETNPIPIKAAMCWFGHCGPEIRLPLTPLSQNETSSKFKKVLEGLKEKGYE
>Mature_307_residues
MIAKSGSNQESNPMFQGVYTAIITPFKNDKIDYDSYFKLLEKQIKAGVSGVVPCGTTGESPTLSHSEHAELIRETVKAVQ
GKIQVVAGTGSNSTKEAIELTEAACKDGVDGILSVNPYYNKPTQEGLFQHFKSIAEHSTVPVMLYNIPGRTSVNLLPETV
LRLSEVKQIRSMKEATGDLGQMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVISNLFPKALVQLVESFQQGKISE
AKKIHYDFIEVFALAFMETNPIPIKAAMCWFGHCGPEIRLPLTPLSQNETSSKFKKVLEGLKEKGYE

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=278, Percent_Identity=30.2158273381295, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI13540533, Length=241, Percent_Identity=30.7053941908714, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=42.5170068027211, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1786463, Length=261, Percent_Identity=29.5019157088123, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082415, Length=275, Percent_Identity=29.8181818181818, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789620, Length=242, Percent_Identity=26.8595041322314, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_LEPIC (Q72U22)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000819.1
- ProteinModelPortal:   Q72U22
- SMR:   Q72U22
- GeneID:   2770130
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10842
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- ProtClustDB:   PRK03170
- BioCyc:   LINT267671:LIC_10842-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 33380; Mature: 33380

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 173-173 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAKSGSNQESNPMFQGVYTAIITPFKNDKIDYDSYFKLLEKQIKAGVSGVVPCGTTGES
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PTLSHSEHAELIRETVKAVQGKIQVVAGTGSNSTKEAIELTEAACKDGVDGILSVNPYYN
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCC
KPTQEGLFQHFKSIAEHSTVPVMLYNIPGRTSVNLLPETVLRLSEVKQIRSMKEATGDLG
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVISNLFPKALVQLVESFQQGKISE
HHHHHHHHHCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AKKIHYDFIEVFALAFMETNPIPIKAAMCWFGHCGPEIRLPLTPLSQNETSSKFKKVLEG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHH
LKEKGYE
HHHCCCC
>Mature Secondary Structure
MIAKSGSNQESNPMFQGVYTAIITPFKNDKIDYDSYFKLLEKQIKAGVSGVVPCGTTGES
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PTLSHSEHAELIRETVKAVQGKIQVVAGTGSNSTKEAIELTEAACKDGVDGILSVNPYYN
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCC
KPTQEGLFQHFKSIAEHSTVPVMLYNIPGRTSVNLLPETVLRLSEVKQIRSMKEATGDLG
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVISNLFPKALVQLVESFQQGKISE
HHHHHHHHHCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AKKIHYDFIEVFALAFMETNPIPIKAAMCWFGHCGPEIRLPLTPLSQNETSSKFKKVLEG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHH
LKEKGYE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA