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The map label for this gene is luxQ [H]

Identifier: 45656450

GI number: 45656450

Start: 675814

End: 677904

Strand: Reverse

Name: luxQ [H]

Synonym: LIC10552

Alternate gene names: 45656450

Gene position: 677904-675814 (Counterclockwise)

Preceding gene: 45656451

Following gene: 45656448

Centisome position: 15.85

GC content: 34.86

Gene sequence:

>2091_bases
ATGAATGAGTCTTCTCATAAAACTTTTACCGATAAAATCAACGAATTCTATAAACGCTCATTTGAACTTTTTTCAAAGGG
ATCATATTTGGAGGAAATGGACAAATTTTACTCTCTTTGTAAAACCACGTTATATGCAGATTTTATAATTTTATTAGAAA
GTAAAGATCCGTTATCCATCAAAATAGTAGAGTCTCAGCCGAAATTTAATTTTTCTATAGACCAAACGAACATAAATTTA
TTGTCTATCTCTTATTCCGAAAATCGCCCTGTTTTACCTTATACACTGACGCGTCAAGAAATCAATTTCTCCAATTTTGA
TGCACTGGAAGAAATTGATTTCGCGCAAATGATCGCAGTTCCTATACCAAATGAAAACATAGAAGACCGAAGAAAAAATA
TTCTTTTATTCTTATATTCAAAAAATACAGAACACATATCTGAATTTTTAAAACTTATCACAGAATTATCTCCTAGAATC
TACGAAATTTTTTCGATTAAAAACAAGGAAATTTTGTTGAATTCAGTTCATTCCAGATTGGATTCCATTTTAAAAACGAT
ACCCCAAGCAATTATCTTTATGGATTCAGGAACTGGAAAAACCTGGATCAACGAAAGTGCGGCAAAACTTCTTTCTCTTT
CTGAAGGAGGAGAAGTCTCTTCTTGGAAAGTTTCCACTTCAATGACCGAGCTGATACAATCCGCAGTCAATCAAAAGGAA
ATCTTTCTAGAAATGAATCGAAATTTATCTAATATGAATCTGGAAAAATTTTCAACTCAGTGGATGTTTACGGACCCGGA
AAAAAAAGTATTCGAGGTTACAAGTTTACTTTTACCCGGTAAAACGGCTCCGGGAAGACTATGGTTTTTCGAAGACATTA
CTTCTTTTCATTCGCAACAAGAAACATTAGCTTTATTGAATCAAGCTTTAAAGGAAAAAAGTGAAATCGCACAACAGGAG
AATCAAGCAAAAACAGTTTTTATCTCTAACATCAGCCACGAAATTAGAACTCCCATGACCGGAATATTAGGAATCACCGA
ATTACTGTTAAATACTCCTTTAAATCCGGATCAAAAAGACTCCTTAGAGCTTATCCAAAGAAGCGGGGATAAACTTCTTA
AAATCGTAAACCATTTACTTGATTTTTCCAAAGCAGACACCGGAAAAATCGAATTAGAATCAATTCCATTTAATATGCAG
GAATTGTTAAACGATCTTGTTTCTCTCTTACGGACGGAAATACTTAAGAACAAAAACGAATTGAACATACTATTCCCGCC
AAACTTTCCTAAATTGCTTAAAGGAGATCCAGTCAGAATTGGTCAGATTCTTACAAATTTAGTCTCCAATGCGACTAAAT
TTACAAAAGAAGGAACCGTCGAAGTTGGATTTCATATATTAGAAAAAACGAATTCTGAATTGAGTTTCAGAACCTGGGTT
TTTGATACTGGAATCGGAATCCCTCCTACTAAGTTCAACTCCGTATTTGAACCTTTCGTTCAATCCGACAAATCCATCAC
AAGACATTTTGGCGGAACTGGATTAGGGTTATCGATTACAAAAAAACTAATAGAATTGATGGGAGGTAAAATTCATGTGG
AAAGCCAACCTGGAATTGGAACCAGGTTTTGGTTCGAACTCAAACTGGAAATTCCCGAGTCAATCGACGAAGAGTCGTTT
ACTGAAAATTCTGAAGCCGAAGTTATAACAGATAAATCAGATCTTTCTCGTTTAAAGGTTTTGATCGTAGAAGACAATCT
TATCAATCAAAAACTTTTAGGTCGAATTCTAAAAAAGAAAAAGATAGAACCTTTTTTAGTAGAAGATGGAATGAAAGCGA
TAGAAAAGGCGCGAAAATTCCATTACGATCTGATCTTTATGGATATTAATATGCCCGGAATCGACGGACTTTCCGCAACG
GAAATTATCCGTAAATTTCCGAAAGGAGATTCGATTCGTATCGTAGGGCTCACTGCAAACGCCGCTCCGGAAATTCAAAA
GGTCGCGACTCAAAGAGGAATGGACGACCTACTTACAAAGCCGTATAACGTTTCTCAAATAGAAAAAATTTTGAACCTAT
TCGAAAAATGA

Upstream 100 bases:

>100_bases
GATTTTTAAATCGATTCCTGCAACGGGGCATCTACCTCACTTCAGTTCTCCGGAATCTGTACTCCAAGAAATTAAATTGT
TTTTTAAGTCTTTAAATTGA

Downstream 100 bases:

>100_bases
TGATCTTAAACCCATCAAAGCCATACCACTTAACTTATAGTAGAAACTCCGCCATTTTTAGTTTATTTATGGCCGAACTT
TAGAGAGATTTGTCCACTCT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MNESSHKTFTDKINEFYKRSFELFSKGSYLEEMDKFYSLCKTTLYADFIILLESKDPLSIKIVESQPKFNFSIDQTNINL
LSISYSENRPVLPYTLTRQEINFSNFDALEEIDFAQMIAVPIPNENIEDRRKNILLFLYSKNTEHISEFLKLITELSPRI
YEIFSIKNKEILLNSVHSRLDSILKTIPQAIIFMDSGTGKTWINESAAKLLSLSEGGEVSSWKVSTSMTELIQSAVNQKE
IFLEMNRNLSNMNLEKFSTQWMFTDPEKKVFEVTSLLLPGKTAPGRLWFFEDITSFHSQQETLALLNQALKEKSEIAQQE
NQAKTVFISNISHEIRTPMTGILGITELLLNTPLNPDQKDSLELIQRSGDKLLKIVNHLLDFSKADTGKIELESIPFNMQ
ELLNDLVSLLRTEILKNKNELNILFPPNFPKLLKGDPVRIGQILTNLVSNATKFTKEGTVEVGFHILEKTNSELSFRTWV
FDTGIGIPPTKFNSVFEPFVQSDKSITRHFGGTGLGLSITKKLIELMGGKIHVESQPGIGTRFWFELKLEIPESIDEESF
TENSEAEVITDKSDLSRLKVLIVEDNLINQKLLGRILKKKKIEPFLVEDGMKAIEKARKFHYDLIFMDINMPGIDGLSAT
EIIRKFPKGDSIRIVGLTANAAPEIQKVATQRGMDDLLTKPYNVSQIEKILNLFEK

Sequences:

>Translated_696_residues
MNESSHKTFTDKINEFYKRSFELFSKGSYLEEMDKFYSLCKTTLYADFIILLESKDPLSIKIVESQPKFNFSIDQTNINL
LSISYSENRPVLPYTLTRQEINFSNFDALEEIDFAQMIAVPIPNENIEDRRKNILLFLYSKNTEHISEFLKLITELSPRI
YEIFSIKNKEILLNSVHSRLDSILKTIPQAIIFMDSGTGKTWINESAAKLLSLSEGGEVSSWKVSTSMTELIQSAVNQKE
IFLEMNRNLSNMNLEKFSTQWMFTDPEKKVFEVTSLLLPGKTAPGRLWFFEDITSFHSQQETLALLNQALKEKSEIAQQE
NQAKTVFISNISHEIRTPMTGILGITELLLNTPLNPDQKDSLELIQRSGDKLLKIVNHLLDFSKADTGKIELESIPFNMQ
ELLNDLVSLLRTEILKNKNELNILFPPNFPKLLKGDPVRIGQILTNLVSNATKFTKEGTVEVGFHILEKTNSELSFRTWV
FDTGIGIPPTKFNSVFEPFVQSDKSITRHFGGTGLGLSITKKLIELMGGKIHVESQPGIGTRFWFELKLEIPESIDEESF
TENSEAEVITDKSDLSRLKVLIVEDNLINQKLLGRILKKKKIEPFLVEDGMKAIEKARKFHYDLIFMDINMPGIDGLSAT
EIIRKFPKGDSIRIVGLTANAAPEIQKVATQRGMDDLLTKPYNVSQIEKILNLFEK
>Mature_696_residues
MNESSHKTFTDKINEFYKRSFELFSKGSYLEEMDKFYSLCKTTLYADFIILLESKDPLSIKIVESQPKFNFSIDQTNINL
LSISYSENRPVLPYTLTRQEINFSNFDALEEIDFAQMIAVPIPNENIEDRRKNILLFLYSKNTEHISEFLKLITELSPRI
YEIFSIKNKEILLNSVHSRLDSILKTIPQAIIFMDSGTGKTWINESAAKLLSLSEGGEVSSWKVSTSMTELIQSAVNQKE
IFLEMNRNLSNMNLEKFSTQWMFTDPEKKVFEVTSLLLPGKTAPGRLWFFEDITSFHSQQETLALLNQALKEKSEIAQQE
NQAKTVFISNISHEIRTPMTGILGITELLLNTPLNPDQKDSLELIQRSGDKLLKIVNHLLDFSKADTGKIELESIPFNMQ
ELLNDLVSLLRTEILKNKNELNILFPPNFPKLLKGDPVRIGQILTNLVSNATKFTKEGTVEVGFHILEKTNSELSFRTWV
FDTGIGIPPTKFNSVFEPFVQSDKSITRHFGGTGLGLSITKKLIELMGGKIHVESQPGIGTRFWFELKLEIPESIDEESF
TENSEAEVITDKSDLSRLKVLIVEDNLINQKLLGRILKKKKIEPFLVEDGMKAIEKARKFHYDLIFMDINMPGIDGLSAT
EIIRKFPKGDSIRIVGLTANAAPEIQKVATQRGMDDLLTKPYNVSQIEKILNLFEK

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=329, Percent_Identity=36.7781155015198, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI87081816, Length=369, Percent_Identity=31.1653116531165, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI48994928, Length=461, Percent_Identity=30.8026030368764, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788713, Length=409, Percent_Identity=31.7848410757946, Blast_Score=172, Evalue=9e-44,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=36.0655737704918, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=30.9417040358744, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=24.901185770751, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=27.0742358078603, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=27.8481012658228, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790300, Length=371, Percent_Identity=25.8760107816712, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=29.3650793650794, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788393, Length=255, Percent_Identity=25.4901960784314, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=27.7533039647577, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788549, Length=267, Percent_Identity=26.2172284644195, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=237, Percent_Identity=27.8481012658228, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=260, Percent_Identity=23.8461538461538, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788545, Length=250, Percent_Identity=22.8, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=240, Percent_Identity=27.5, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=145, Percent_Identity=33.1034482758621, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6322044, Length=78, Percent_Identity=48.7179487179487, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323034, Length=139, Percent_Identity=34.5323741007194, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79305; Mature: 79305

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESSHKTFTDKINEFYKRSFELFSKGSYLEEMDKFYSLCKTTLYADFIILLESKDPLSI
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEE
KIVESQPKFNFSIDQTNINLLSISYSENRPVLPYTLTRQEINFSNFDALEEIDFAQMIAV
EEEECCCCEEEEEECCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHCCHHHEEEE
PIPNENIEDRRKNILLFLYSKNTEHISEFLKLITELSPRIYEIFSIKNKEILLNSVHSRL
ECCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHH
DSILKTIPQAIIFMDSGTGKTWINESAAKLLSLSEGGEVSSWKVSTSMTELIQSAVNQKE
HHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCHHH
IFLEMNRNLSNMNLEKFSTQWMFTDPEKKVFEVTSLLLPGKTAPGRLWFFEDITSFHSQQ
EEEEECCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
ETLALLNQALKEKSEIAQQENQAKTVFISNISHEIRTPMTGILGITELLLNTPLNPDQKD
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCCCCHH
SLELIQRSGDKLLKIVNHLLDFSKADTGKIELESIPFNMQELLNDLVSLLRTEILKNKNE
HHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
LNILFPPNFPKLLKGDPVRIGQILTNLVSNATKFTKEGTVEVGFHILEKTNSELSFRTWV
EEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEE
FDTGIGIPPTKFNSVFEPFVQSDKSITRHFGGTGLGLSITKKLIELMGGKIHVESQPGIG
EECCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEECCCCCC
TRFWFELKLEIPESIDEESFTENSEAEVITDKSDLSRLKVLIVEDNLINQKLLGRILKKK
EEEEEEEEEECCCCCCCHHCCCCCCCEEEECHHHHCCEEEEEEECCHHHHHHHHHHHHHH
KIEPFLVEDGMKAIEKARKFHYDLIFMDINMPGIDGLSATEIIRKFPKGDSIRIVGLTAN
CCCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECC
AAPEIQKVATQRGMDDLLTKPYNVSQIEKILNLFEK
CCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNESSHKTFTDKINEFYKRSFELFSKGSYLEEMDKFYSLCKTTLYADFIILLESKDPLSI
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEE
KIVESQPKFNFSIDQTNINLLSISYSENRPVLPYTLTRQEINFSNFDALEEIDFAQMIAV
EEEECCCCEEEEEECCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHCCHHHEEEE
PIPNENIEDRRKNILLFLYSKNTEHISEFLKLITELSPRIYEIFSIKNKEILLNSVHSRL
ECCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHH
DSILKTIPQAIIFMDSGTGKTWINESAAKLLSLSEGGEVSSWKVSTSMTELIQSAVNQKE
HHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCHHH
IFLEMNRNLSNMNLEKFSTQWMFTDPEKKVFEVTSLLLPGKTAPGRLWFFEDITSFHSQQ
EEEEECCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
ETLALLNQALKEKSEIAQQENQAKTVFISNISHEIRTPMTGILGITELLLNTPLNPDQKD
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCCCCHH
SLELIQRSGDKLLKIVNHLLDFSKADTGKIELESIPFNMQELLNDLVSLLRTEILKNKNE
HHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
LNILFPPNFPKLLKGDPVRIGQILTNLVSNATKFTKEGTVEVGFHILEKTNSELSFRTWV
EEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEE
FDTGIGIPPTKFNSVFEPFVQSDKSITRHFGGTGLGLSITKKLIELMGGKIHVESQPGIG
EECCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEECCCCCC
TRFWFELKLEIPESIDEESFTENSEAEVITDKSDLSRLKVLIVEDNLINQKLLGRILKKK
EEEEEEEEEECCCCCCCHHCCCCCCCEEEECHHHHCCEEEEEEECCHHHHHHHHHHHHHH
KIEPFLVEDGMKAIEKARKFHYDLIFMDINMPGIDGLSATEIIRKFPKGDSIRIVGLTAN
CCCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECC
AAPEIQKVATQRGMDDLLTKPYNVSQIEKILNLFEK
CCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]