Click here to switch to the map view.

The map label for this gene is lhr [C]

Identifier: 45358847

GI number: 45358847

Start: 1265602

End: 1268037

Strand: Direct

Name: lhr [C]

Synonym: MMP1284

Alternate gene names: 45358847

Gene position: 1265602-1268037 (Clockwise)

Preceding gene: 45358844

Following gene: 45358849

Centisome position: 76.19

GC content: 31.16

Gene sequence:

>2436_bases
ATGATTATCGTGAGAAAATTAAAGAAAAAGAAAGAAGAGATCCAATTTATTGATTTAACCGATGAAAAGACTTATTATGG
GATAATAAGACCTGCAAACAATAGAATTACACTTTACAAATGTAGGGAAGAAAAAGCAGGAAATGTAAACCCAATACAAC
CTTCAAAATTGATAAATTTCGTTAGATCAAACAAAGTTTTATTAAGTGGGGATGAAGAATCGTTAAAATTAGAAGAATTC
CTCAAACAAAATAATATCAAACACGGATATATTGATTTATGCCCTTTTTGCATTATTAAAGGAAAATTTAGCGAGATCAC
GGATAAATATAAAATTTACAACAGCGAGATCTGCCTTGAATGTGCAATCGATGAAGTAAAACATGAAATAAATATCAATG
AGGAATTTATTGAAAAATTACTTAGAAGATTCAAAGACGCAAATAAAGTAATTGAACTATTCAAATCAAAAAACCCGCTT
AAAAATCCGGAACTTACAAAATACGACGTTTTAACCGGAAACGTTGACGACAACATAAAAAATTATGGAATAAATGAACT
GGATATTCCTGATTTTTTAAAAGAAATTATTAAAAATAGAGGGATAGATGAATTACTCCCAGTTCAGACTCTATCTGTAA
AAGCTGGGCTTTTAAAAAATGATAATTTATTGATTACGTCTGCAACGTCTTCTGGAAAAACTTTGATTGGAGAACTTGCA
GGAATTAAAAATATTTCCGAAAAAAAGGGTAAATTTTTATTTTTAGTTCCATTAGTTGCCCTTGCAAATCAAAAATATGT
TGAATTTAAAGATAGATACGAAAAAGAAGGTTATTCAGTATCGTTAAGAGTTGGAACCGGAAGACTTTCAGAAAACAAAG
GAGGCGGTATCAATTCAAGCCTTGATTCGGACATAATAATTGGAACCTACGAAGGAATAGATTATTTGATAAGATCGGGA
AAATTAAAAGATGTTGGAACCGTTGTAATTGATGAAGTCCACTCTATGAATATGGATGAACGTGGTGCACGTCTTGACGG
CCTTATCGGACGATTAAGGTATTTATTCACCTGTCAGATGATATATCTTTCTGCAACTGTTGGAAATCCAGAAGAATTAG
CTTCAAAATTGGGTTCAAAACTTGTTTTATACAATGGAAGGCCAGTTCCTCTTGAAAGGCACTTAATTTTCACCAAAAAC
GATTATGGAAAATTAAATCTTGTAAATGATATTGTTAAACAGGAATTTAGTTCAAAATCAAAGTACGGATTTAGAGGCCA
GAGTTTAATATTTACATTTTCAAGAAAAAGAGCAGAATATATCTCAAATTACTTAAATACCAAAGGAATAAAGTCAGATT
ACTACCACGGCGGAATGGAGTATTCAAAAAGGCGAACTGTTGAAGATAATTTTCTAAAGCAGAAAACAATGTGTGTAGTA
ACTACCGCAGCACTTGCAGCTGGTGTGGATTTTGCGGCATCCACTGTTGTTTTAGAAAGTCTTGCAATGGGTGGAGACTG
GTTAAACCCATCAGAATTCCAGCAGATGTGTGGAAGAGCTGGAAGAAAAGGAATGCATGATAAAGGAAAAGTTTACAGCC
TTGTTGAAATTGGTAAAAAATATCACGCAAAAATGGAAAATTCTGAAGATGAGGTTTCGTTTAAACTGTTAAATTCAGAA
CCTGAAGAAGTTTCATTAGAATACAGTGAAGATGAAGAATTTGAACAGGTTTTAGCAAACGTATGTTCAATTAAAAATTA
CAAAAATAAAGTTACAATTCCTGATGTTTCAAAAGTTCCAGTTCTTGGAAAAAATTTAGGTTTAAATTATGTTTTAGAAT
CACTTTCGGGCTATCAAATGCTTGATTTGCAGAACAAAAACATAAATACAACCCGATACGGTTATGCAACGTCAATTTCA
TTTTTGTATCCTAAAGATGCTGAAAAAATAAGGAAAAATCTGCATAAAAACCCCCTCGACATTGTTGTATCAATTTCACC
CTTTGAAAATGCATATATTCCTGCAAACCTGAAAAATAAAATCTCAAAAACCACAAATGTAAACATTCCAACTAGATTTA
CCGATGCTTTCGAAGTAATAAAAGAAAATTTTGAAAAAATAAAAGATAAAACCTTGAGGGATGAAATTCTGCCTTGGTTA
ATCGAATTTGATGGATTGATTGAAGAGGATATTATAAACTACAATTCCAAAAAAGTTCTGAATTTAAGAATAAACAAAAA
AACACCGCTTCAGATATCAAAAATAATTCATGATACCTTGAAACTTCAAACATACAGTGGAGACATCTATTCGTACCTTG
AAACTTCAATAAATACTCTTGATGCGGTTGAAAGAATTGGAAATATTTATAATAAAAAAATAGCGAAAGAATCTGCTAAA
TTAAAGAAAAAAATGGAAAATCCATATAAAAATTAA

Upstream 100 bases:

>100_bases
TTATTATATACCTTTAAATTATATAGCTTTGTACCATTTTCATAGATTTATAATATTATCTGTAATTTATGGTTTTTATT
AGTGATTATTTGGTGAATCC

Downstream 100 bases:

>100_bases
CTAAAATCTATTTTTTTAATACCTAAATACGAATAAATGTTTTCATTTGACTCGACATTAATAAACCTGTTTTCTTCTTT
TGTAAAATCCAAAAATTCAT

Product: DEAD/DEAH box helicase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MIIVRKLKKKKEEIQFIDLTDEKTYYGIIRPANNRITLYKCREEKAGNVNPIQPSKLINFVRSNKVLLSGDEESLKLEEF
LKQNNIKHGYIDLCPFCIIKGKFSEITDKYKIYNSEICLECAIDEVKHEININEEFIEKLLRRFKDANKVIELFKSKNPL
KNPELTKYDVLTGNVDDNIKNYGINELDIPDFLKEIIKNRGIDELLPVQTLSVKAGLLKNDNLLITSATSSGKTLIGELA
GIKNISEKKGKFLFLVPLVALANQKYVEFKDRYEKEGYSVSLRVGTGRLSENKGGGINSSLDSDIIIGTYEGIDYLIRSG
KLKDVGTVVIDEVHSMNMDERGARLDGLIGRLRYLFTCQMIYLSATVGNPEELASKLGSKLVLYNGRPVPLERHLIFTKN
DYGKLNLVNDIVKQEFSSKSKYGFRGQSLIFTFSRKRAEYISNYLNTKGIKSDYYHGGMEYSKRRTVEDNFLKQKTMCVV
TTAALAAGVDFAASTVVLESLAMGGDWLNPSEFQQMCGRAGRKGMHDKGKVYSLVEIGKKYHAKMENSEDEVSFKLLNSE
PEEVSLEYSEDEEFEQVLANVCSIKNYKNKVTIPDVSKVPVLGKNLGLNYVLESLSGYQMLDLQNKNINTTRYGYATSIS
FLYPKDAEKIRKNLHKNPLDIVVSISPFENAYIPANLKNKISKTTNVNIPTRFTDAFEVIKENFEKIKDKTLRDEILPWL
IEFDGLIEEDIINYNSKKVLNLRINKKTPLQISKIIHDTLKLQTYSGDIYSYLETSINTLDAVERIGNIYNKKIAKESAK
LKKKMENPYKN

Sequences:

>Translated_811_residues
MIIVRKLKKKKEEIQFIDLTDEKTYYGIIRPANNRITLYKCREEKAGNVNPIQPSKLINFVRSNKVLLSGDEESLKLEEF
LKQNNIKHGYIDLCPFCIIKGKFSEITDKYKIYNSEICLECAIDEVKHEININEEFIEKLLRRFKDANKVIELFKSKNPL
KNPELTKYDVLTGNVDDNIKNYGINELDIPDFLKEIIKNRGIDELLPVQTLSVKAGLLKNDNLLITSATSSGKTLIGELA
GIKNISEKKGKFLFLVPLVALANQKYVEFKDRYEKEGYSVSLRVGTGRLSENKGGGINSSLDSDIIIGTYEGIDYLIRSG
KLKDVGTVVIDEVHSMNMDERGARLDGLIGRLRYLFTCQMIYLSATVGNPEELASKLGSKLVLYNGRPVPLERHLIFTKN
DYGKLNLVNDIVKQEFSSKSKYGFRGQSLIFTFSRKRAEYISNYLNTKGIKSDYYHGGMEYSKRRTVEDNFLKQKTMCVV
TTAALAAGVDFAASTVVLESLAMGGDWLNPSEFQQMCGRAGRKGMHDKGKVYSLVEIGKKYHAKMENSEDEVSFKLLNSE
PEEVSLEYSEDEEFEQVLANVCSIKNYKNKVTIPDVSKVPVLGKNLGLNYVLESLSGYQMLDLQNKNINTTRYGYATSIS
FLYPKDAEKIRKNLHKNPLDIVVSISPFENAYIPANLKNKISKTTNVNIPTRFTDAFEVIKENFEKIKDKTLRDEILPWL
IEFDGLIEEDIINYNSKKVLNLRINKKTPLQISKIIHDTLKLQTYSGDIYSYLETSINTLDAVERIGNIYNKKIAKESAK
LKKKMENPYKN
>Mature_811_residues
MIIVRKLKKKKEEIQFIDLTDEKTYYGIIRPANNRITLYKCREEKAGNVNPIQPSKLINFVRSNKVLLSGDEESLKLEEF
LKQNNIKHGYIDLCPFCIIKGKFSEITDKYKIYNSEICLECAIDEVKHEININEEFIEKLLRRFKDANKVIELFKSKNPL
KNPELTKYDVLTGNVDDNIKNYGINELDIPDFLKEIIKNRGIDELLPVQTLSVKAGLLKNDNLLITSATSSGKTLIGELA
GIKNISEKKGKFLFLVPLVALANQKYVEFKDRYEKEGYSVSLRVGTGRLSENKGGGINSSLDSDIIIGTYEGIDYLIRSG
KLKDVGTVVIDEVHSMNMDERGARLDGLIGRLRYLFTCQMIYLSATVGNPEELASKLGSKLVLYNGRPVPLERHLIFTKN
DYGKLNLVNDIVKQEFSSKSKYGFRGQSLIFTFSRKRAEYISNYLNTKGIKSDYYHGGMEYSKRRTVEDNFLKQKTMCVV
TTAALAAGVDFAASTVVLESLAMGGDWLNPSEFQQMCGRAGRKGMHDKGKVYSLVEIGKKYHAKMENSEDEVSFKLLNSE
PEEVSLEYSEDEEFEQVLANVCSIKNYKNKVTIPDVSKVPVLGKNLGLNYVLESLSGYQMLDLQNKNINTTRYGYATSIS
FLYPKDAEKIRKNLHKNPLDIVVSISPFENAYIPANLKNKISKTTNVNIPTRFTDAFEVIKENFEKIKDKTLRDEILPWL
IEFDGLIEEDIINYNSKKVLNLRINKKTPLQISKIIHDTLKLQTYSGDIYSYLETSINTLDAVERIGNIYNKKIAKESAK
LKKKMENPYKN

Specific function: Unknown

COG id: COG1202

COG function: function code R; Superfamily II helicase, archaea-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI40217847, Length=460, Percent_Identity=24.1304347826087, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI169218225, Length=460, Percent_Identity=24.3478260869565, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI139394648, Length=234, Percent_Identity=29.4871794871795, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI38569503, Length=357, Percent_Identity=26.0504201680672, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI38569505, Length=357, Percent_Identity=26.0504201680672, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI67782311, Length=253, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI110556640, Length=199, Percent_Identity=28.643216080402, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995032, Length=381, Percent_Identity=24.6719160104987, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17537519, Length=425, Percent_Identity=26.3529411764706, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17542826, Length=408, Percent_Identity=24.7549019607843, Blast_Score=91, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321020, Length=415, Percent_Identity=25.5421686746988, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI9755332, Length=531, Percent_Identity=25.8003766478343, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321710, Length=382, Percent_Identity=23.0366492146597, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322411, Length=273, Percent_Identity=26.3736263736264, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323430, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647182, Length=423, Percent_Identity=25.0591016548463, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574898, Length=412, Percent_Identity=25, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17933644, Length=244, Percent_Identity=29.5081967213115, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864608, Length=203, Percent_Identity=30.5418719211823, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR014014 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 92331; Mature: 92331

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVRKLKKKKEEIQFIDLTDEKTYYGIIRPANNRITLYKCREEKAGNVNPIQPSKLINF
CEEHHHHHHHHHHEEEEEECCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHH
VRSNKVLLSGDEESLKLEEFLKQNNIKHGYIDLCPFCIIKGKFSEITDKYKIYNSEICLE
HHCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHCCHHHCCCCHHHHHHHHEEECCCHHHH
CAIDEVKHEININEEFIEKLLRRFKDANKVIELFKSKNPLKNPELTKYDVLTGNVDDNIK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHH
NYGINELDIPDFLKEIIKNRGIDELLPVQTLSVKAGLLKNDNLLITSATSSGKTLIGELA
HCCCCCCCHHHHHHHHHHHCCCCHHCCCHHEEEHHCEEECCCEEEEECCCCCCHHHHHHH
GIKNISEKKGKFLFLVPLVALANQKYVEFKDRYEKEGYSVSLRVGTGRLSENKGGGINSS
CCCCCHHHCCCEEEEEHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
LDSDIIIGTYEGIDYLIRSGKLKDVGTVVIDEVHSMNMDERGARLDGLIGRLRYLFTCQM
CCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IYLSATVGNPEELASKLGSKLVLYNGRPVPLERHLIFTKNDYGKLNLVNDIVKQEFSSKS
HEEEECCCCHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
KYGFRGQSLIFTFSRKRAEYISNYLNTKGIKSDYYHGGMEYSKRRTVEDNFLKQKTMCVV
CCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHEE
TTAALAAGVDFAASTVVLESLAMGGDWLNPSEFQQMCGRAGRKGMHDKGKVYSLVEIGKK
EHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
YHAKMENSEDEVSFKLLNSEPEEVSLEYSEDEEFEQVLANVCSIKNYKNKVTIPDVSKVP
HHHHCCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCC
VLGKNLGLNYVLESLSGYQMLDLQNKNINTTRYGYATSISFLYPKDAEKIRKNLHKNPLD
CCCCCCCHHHHHHHCCCCEEEEECCCCCCCEECCCEEEEEEECCCCHHHHHHHHCCCCEE
IVVSISPFENAYIPANLKNKISKTTNVNIPTRFTDAFEVIKENFEKIKDKTLRDEILPWL
EEEEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEFDGLIEEDIINYNSKKVLNLRINKKTPLQISKIIHDTLKLQTYSGDIYSYLETSINTL
HHHCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEECCHHHHHHHHHHHHH
DAVERIGNIYNKKIAKESAKLKKKMENPYKN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIIVRKLKKKKEEIQFIDLTDEKTYYGIIRPANNRITLYKCREEKAGNVNPIQPSKLINF
CEEHHHHHHHHHHEEEEEECCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHH
VRSNKVLLSGDEESLKLEEFLKQNNIKHGYIDLCPFCIIKGKFSEITDKYKIYNSEICLE
HHCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHCCHHHCCCCHHHHHHHHEEECCCHHHH
CAIDEVKHEININEEFIEKLLRRFKDANKVIELFKSKNPLKNPELTKYDVLTGNVDDNIK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHH
NYGINELDIPDFLKEIIKNRGIDELLPVQTLSVKAGLLKNDNLLITSATSSGKTLIGELA
HCCCCCCCHHHHHHHHHHHCCCCHHCCCHHEEEHHCEEECCCEEEEECCCCCCHHHHHHH
GIKNISEKKGKFLFLVPLVALANQKYVEFKDRYEKEGYSVSLRVGTGRLSENKGGGINSS
CCCCCHHHCCCEEEEEHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
LDSDIIIGTYEGIDYLIRSGKLKDVGTVVIDEVHSMNMDERGARLDGLIGRLRYLFTCQM
CCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IYLSATVGNPEELASKLGSKLVLYNGRPVPLERHLIFTKNDYGKLNLVNDIVKQEFSSKS
HEEEECCCCHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
KYGFRGQSLIFTFSRKRAEYISNYLNTKGIKSDYYHGGMEYSKRRTVEDNFLKQKTMCVV
CCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHEE
TTAALAAGVDFAASTVVLESLAMGGDWLNPSEFQQMCGRAGRKGMHDKGKVYSLVEIGKK
EHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
YHAKMENSEDEVSFKLLNSEPEEVSLEYSEDEEFEQVLANVCSIKNYKNKVTIPDVSKVP
HHHHCCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCC
VLGKNLGLNYVLESLSGYQMLDLQNKNINTTRYGYATSISFLYPKDAEKIRKNLHKNPLD
CCCCCCCHHHHHHHCCCCEEEEECCCCCCCEECCCEEEEEEECCCCHHHHHHHHCCCCEE
IVVSISPFENAYIPANLKNKISKTTNVNIPTRFTDAFEVIKENFEKIKDKTLRDEILPWL
EEEEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEFDGLIEEDIINYNSKKVLNLRINKKTPLQISKIIHDTLKLQTYSGDIYSYLETSINTL
HHHCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEECCHHHHHHHHHHHHH
DAVERIGNIYNKKIAKESAKLKKKMENPYKN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]