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The map label for this gene is mmsB

Identifier: 41410311

GI number: 41410311

Start: 4682848

End: 4683735

Strand: Reverse

Name: mmsB

Synonym: MAP4213c

Alternate gene names: 41410311

Gene position: 4683735-4682848 (Counterclockwise)

Preceding gene: 41410312

Following gene: 41410305

Centisome position: 96.98

GC content: 70.16

Gene sequence:

>888_bases
ATGACCGAGCGCGTGGTGGTGGCTTTCCTGGGCCTGGGCAACATGGGCGCGCCGATGGCGGCGAATCTCGTTGCGGCCCA
ACATGCGGTGCGCGGATTCGATCCGGTGCCCGCGGCGCTGTCGGCCGCCACCGCGTCCGGTGTCACCGGTTTCGACACCG
CCACCGACGCGGTGACGGGGGCCGACGTGGTGATCACCATGCTGCCCAACGGCGAGGTGGTCAAACGCTGCTACGCCGAG
ATCCTGCCCGCCGCGCGCCCGGGCGCGCTGTTCATCGACAGCTCCACGATCTCGGTCGCCGACGCCCGCGAGGTGCACGC
GCAAGCGCAGTCGCACGGCGTGGCGCAGCTCGACGCGCCCGTCTCGGGCGGGGTGAAGGGTGCGGTCGCCGGCACGCTGG
CGTTCATGGTGGGCGGCGAACCCGAGGCCCTGGAGCGGGCCCGGCCGGTGCTGGAACCCATGGCGGGCAAGATCATTCAC
TGCGGTGCGGCCGGGGCCGGGCAGGCCGCCAAGGTGTGCAACAACATGGTGCTGGCGGTGCAGCAGATCGCCATCGGCGA
GGCATTCATCCTGGCCGAAAAGCTCGGGTTGTCGGCGCAGTCGCTGTTCGACGTGATCACCGGGGCGACCGGCAACTGCT
GGGCCGTGCACACCAATTGCCCGGTGCCGGGCCCGGTTCCGACGTCGCCGGCCAACAACGACTTCAAGCCGGGCTTCGCC
GCCTCGCTGATGAACAAGGACCTGGGTCTTGCGATGGACGCGGTGACCTCGACCGGCGCGGCCGCCCCGCTGGGCCGGCA
TGCCGCGGAGATTTACGCAAAATTCGCCGCCTCCCACGGCGACAAGGACTTCAGTGCGGTCATCGAGATGCTGCGCGGCG
CTTGCTAG

Upstream 100 bases:

>100_bases
GGTGCATCGCATCCTGGAGGGGACCAACGAGATCATGCGGGTGGTCATCGGCCGGGCCGAAGCGGCGCGGTTCCGGGCCA
CCGCATAGAAAGGCCGTCGG

Downstream 100 bases:

>100_bases
CACCGAGCGTCACGCTGGCGTGGCACCCGGGCGCGACGGTCACGCTGGCGTGACGCTCGGCGCCGCGGGGCGAGTTCAGA
AGTCGCCCGCGTTGCGGCGC

Product: MmsB

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTERVVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTGFDTATDAVTGADVVITMLPNGEVVKRCYAE
ILPAARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTLAFMVGGEPEALERARPVLEPMAGKIIH
CGAAGAGQAAKVCNNMVLAVQQIAIGEAFILAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFA
ASLMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGDKDFSAVIEMLRGAC

Sequences:

>Translated_295_residues
MTERVVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTGFDTATDAVTGADVVITMLPNGEVVKRCYAE
ILPAARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTLAFMVGGEPEALERARPVLEPMAGKIIH
CGAAGAGQAAKVCNNMVLAVQQIAIGEAFILAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFA
ASLMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGDKDFSAVIEMLRGAC
>Mature_294_residues
TERVVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTGFDTATDAVTGADVVITMLPNGEVVKRCYAEI
LPAARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTLAFMVGGEPEALERARPVLEPMAGKIIHC
GAAGAGQAAKVCNNMVLAVQQIAIGEAFILAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFAA
SLMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGDKDFSAVIEMLRGAC

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=290, Percent_Identity=40.6896551724138, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI40556376, Length=287, Percent_Identity=24.7386759581882, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI145693186, Length=285, Percent_Identity=34.3859649122807, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=33.6769759450172, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786719, Length=294, Percent_Identity=31.2925170068027, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1789092, Length=295, Percent_Identity=32.2033898305085, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=293, Percent_Identity=37.8839590443686, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=42.0138888888889, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=42.0138888888889, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29698; Mature: 29567

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERVVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTGFDTATDAVTG
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHCCC
ADVVITMLPNGEVVKRCYAEILPAARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAP
CCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCEEEHHHHHHHHHHHHHCCCEEECCC
VSGGVKGAVAGTLAFMVGGEPEALERARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAV
CCCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
QQIAIGEAFILAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFA
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHH
ASLMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGDKDFSAVIEMLRGAC
HHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TERVVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTGFDTATDAVTG
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHCCC
ADVVITMLPNGEVVKRCYAEILPAARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAP
CCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCEEEHHHHHHHHHHHHHCCCEEECCC
VSGGVKGAVAGTLAFMVGGEPEALERARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAV
CCCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
QQIAIGEAFILAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFA
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHH
ASLMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGDKDFSAVIEMLRGAC
HHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]