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The map label for this gene is mmaA2

Identifier: 41410193

GI number: 41410193

Start: 4570289

End: 4571155

Strand: Reverse

Name: mmaA2

Synonym: MAP4095c

Alternate gene names: 41410193

Gene position: 4571155-4570289 (Counterclockwise)

Preceding gene: 41410198

Following gene: 41410192

Centisome position: 94.65

GC content: 65.74

Gene sequence:

>867_bases
GTGGCAGAGAATCTGACACCGCACTTCGAAGAGGTACAGGCCCACTACGACTTGTCCGACGACTTCTTCCGGCTGTTCCT
CGACCCCACCATGACCTACAGCTGCGCCTATTGGGATCGCAACCGCGACATCTCGCTGGAGGAGGCGCAGCTGCGCAAGA
TCGACCTGTCACTGGGCAAGCTGGGGCTGCGGCCCGGGATGACGCTGCTCGACGTGGGCTGCGGCTGGGGCGCCACCATG
CGCCGCGCCGTCGAGAACTACGACGTCAACGTCATCGGCCTGACCCTGTCCCGGCACCAGGCCGCCCACGTGCAGCAGCT
GCTCGACGCGATGGACACCCCGCGCAGCAGGCGGGTGCTGCTGCACGGCTGGGAGGAGTTCGACGAGCCGGTCGACCGAA
TCGTCTCCATCGGCGCGTTCGAGCATTTCGGCTACGACCGCTACGACGACTTCTTCGCGACCGCCTACCGGGTACTGCCC
GACGACGGGGTGATGCTGCTGCACACCATCACCATGCTGACCCCGGAGCAGATCGTGGAGCGCGGCCTGCCGCTCACCGA
GGAGCAGACCAGCTTCAACGAATTCATCGCCACCGAGATCTTCCCCGGCGGGCAGCTGCCGGCCATCGAGGTCGTGGAGT
TCCACTCCTCGAAGATGGGGTTCACCCTCAAACGCCGGCAGTCCCTGCAGCTGCACTACGCCCGCACGCTCGACCACTGG
GCCGATGCGTTGCGCGCGCACCACAGCGAGGCCGTCGCGATCCAGTCCGAAGAGGTCTACCAGCGCTACATGAGGTATCT
GACCGGCTGCGCCGACGCGTTCCGGGCCGGCTACATCGACGTCAACCAGTTCACGCTGGCCAAGTAA

Upstream 100 bases:

>100_bases
CGGTTAGACGATGTGGAACCGGGGAAGCCGAGGTGAACCGACTCACCGGCCCGTTCGTGACAACCCCAATGGCCCCGAGT
CAGAAAGGCGAGTAGCCGCC

Downstream 100 bases:

>100_bases
CCCCCGCCCGTCGGTGCCCGGGTTTATCGTGACAGCGCAATGCCGCTTCACCTGCACCGTGCCGAGCGCACCGATCTGCT
GGCCGACGGTCTCGGCGCGC

Product: MmaA2

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MAENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDISLEEAQLRKIDLSLGKLGLRPGMTLLDVGCGWGATM
RRAVENYDVNVIGLTLSRHQAAHVQQLLDAMDTPRSRRVLLHGWEEFDEPVDRIVSIGAFEHFGYDRYDDFFATAYRVLP
DDGVMLLHTITMLTPEQIVERGLPLTEEQTSFNEFIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHW
ADALRAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK

Sequences:

>Translated_288_residues
MAENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDISLEEAQLRKIDLSLGKLGLRPGMTLLDVGCGWGATM
RRAVENYDVNVIGLTLSRHQAAHVQQLLDAMDTPRSRRVLLHGWEEFDEPVDRIVSIGAFEHFGYDRYDDFFATAYRVLP
DDGVMLLHTITMLTPEQIVERGLPLTEEQTSFNEFIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHW
ADALRAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK
>Mature_287_residues
AENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDISLEEAQLRKIDLSLGKLGLRPGMTLLDVGCGWGATMR
RAVENYDVNVIGLTLSRHQAAHVQQLLDAMDTPRSRRVLLHGWEEFDEPVDRIVSIGAFEHFGYDRYDDFFATAYRVLPD
DGVMLLHTITMLTPEQIVERGLPLTEEQTSFNEFIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHWA
DALRAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK

Specific function: Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfers of a methylene group from S-adenosyl-L- methionine. MmaA2 also catalyzes the biosynthesis of the cis- cyclopropanated me

COG id: COG2230

COG function: function code M; Cyclopropane fatty acid synthase and related methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=278, Percent_Identity=35.9712230215827, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI133904226, Length=287, Percent_Identity=32.0557491289199, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 33146; Mature: 33015

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDISLEEAQLRKIDLSLGK
CCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHC
LGLRPGMTLLDVGCGWGATMRRAVENYDVNVIGLTLSRHQAAHVQQLLDAMDTPRSRRVL
CCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEE
LHGWEEFDEPVDRIVSIGAFEHFGYDRYDDFFATAYRVLPDDGVMLLHTITMLTPEQIVE
EECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHCCHHHHHH
RGLPLTEEQTSFNEFIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHW
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCEEEHHHHHHHHHHHHHHHHH
ADALRAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK
HHHHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHCCCEECCCEEECC
>Mature Secondary Structure 
AENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDISLEEAQLRKIDLSLGK
CCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHC
LGLRPGMTLLDVGCGWGATMRRAVENYDVNVIGLTLSRHQAAHVQQLLDAMDTPRSRRVL
CCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEE
LHGWEEFDEPVDRIVSIGAFEHFGYDRYDDFFATAYRVLPDDGVMLLHTITMLTPEQIVE
EECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHCCHHHHHH
RGLPLTEEQTSFNEFIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHW
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCEEEHHHHHHHHHHHHHHHHH
ADALRAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK
HHHHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHCCCEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044265; 12788972 [H]