Click here to switch to the map view.

The map label for this gene is galK

Identifier: 41410170

GI number: 41410170

Start: 4538611

End: 4539702

Strand: Direct

Name: galK

Synonym: MAP4072

Alternate gene names: 41410170

Gene position: 4538611-4539702 (Clockwise)

Preceding gene: 41410169

Following gene: 41410171

Centisome position: 93.97

GC content: 74.54

Gene sequence:

>1092_bases
ATGACCGTCCGCTACGCTGCGCCCGGCCGGATCAACCTGATCGGCGAACACACCGACTACAACCTGGGTTTCGCGCTGCC
GATCGCCCTGCCCCAGCGCACCGTGGCCAGCTTCACGCGCGCCGACGACGATGCCATCACGGTGGTCAGCGACCGCGCGG
ACGCGCCGGTGCGGATCCCGATCGACACCGGCCCCGGCGACGTCACCGGCTGGGCGGCCTATCCGGCCGGGGTGATGTGG
GCGCTGCGCACCGCCGGCCACCCGGTGCCCGGCGGGGTGATGTCGATCACCAGCGACGTGCCGATGGGTTCGGGCCTGTC
GTCCTCGGCGGCGCTGGAATGCGCCGTGCTGGGCGCGATCTCGTCGGCCGCCGGGATTCGCATCGACGCCACCGAACAGG
CCCGGCTGGCCCAGCGCGCCGAAAACGAATACGTCGGCGCCCCAACGGGTTTGCTCGACCAGCTGGCCGCGCTGTACGGC
CGCCCGGCCACCGCGGTGCTGATCGACTTCGCCGACCTGGCCGTCACACCGGTGGCCTTCGACCCCGACGCCGCCGGGGT
CGCCCTGTTGCTGATCGACTCCCGGGAGCGCCACACCCACGCCGGCGGCGACTACGCGGCCCGGCGGCTGTCCTGCGAGC
GGGCGGCCGCCGACCTGTCCGCGTCCTCGCTGCGGGAGGCCGCCGACCGCGGCTGCACCGACCTGGCCGCGGTGCGCGAC
GCCGTCGACGCCCGCCGCGCCCGCCACGTGCTCACCGAGAACCGGCGGGTCATCGATTGCGTTGCGGCGCTGAACAATTC
GGACTACCCCGAGGCGGGGCGGATCTTCACCGCCTCGCATGCCTCCATGCGCGACGACTTCGGCATCACCACCGAACGCA
TCGACTTGATCGCCGACACCGCGCTGCGCGCCGGCGCGCTGGGGGCACGGATGACCGGCGGCGGGTTCGGCGGCTGCGTG
ATTGCCCTGGCGCCGGTGCAGCGCGCCGAGGCGATCGGGCACGCGGTCCGGCGGGCCGCGACGCAGGCCGGCTTCGCGCA
ACCCGTCGTCACCCGAACCCGCGCCGCCGCGGGCGCGGGCCCGTGCCGGTGA

Upstream 100 bases:

>100_bases
CGACCAAGCTCAAATTCCTCGCCGCCTCCGAATCGGCGATGGACGCCTTCATCAGCGACGTCACCCCGGAAAGCGTGGCC
CAGCGGCTGCGGGAGCTGCG

Downstream 100 bases:

>100_bases
GCGAGCCGGCCGGCTACGTGGAGGTTCGGGCCTACGCCGAACTCAACGACTTTCTGCCCGCCGAGTCGCGCGGCGCCGCG
GTGCGCCGCCCGTTCCGGGC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVASFTRADDDAITVVSDRADAPVRIPIDTGPGDVTGWAAYPAGVMW
ALRTAGHPVPGGVMSITSDVPMGSGLSSSAALECAVLGAISSAAGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYG
RPATAVLIDFADLAVTPVAFDPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASSLREAADRGCTDLAAVRD
AVDARRARHVLTENRRVIDCVAALNNSDYPEAGRIFTASHASMRDDFGITTERIDLIADTALRAGALGARMTGGGFGGCV
IALAPVQRAEAIGHAVRRAATQAGFAQPVVTRTRAAAGAGPCR

Sequences:

>Translated_363_residues
MTVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVASFTRADDDAITVVSDRADAPVRIPIDTGPGDVTGWAAYPAGVMW
ALRTAGHPVPGGVMSITSDVPMGSGLSSSAALECAVLGAISSAAGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYG
RPATAVLIDFADLAVTPVAFDPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASSLREAADRGCTDLAAVRD
AVDARRARHVLTENRRVIDCVAALNNSDYPEAGRIFTASHASMRDDFGITTERIDLIADTALRAGALGARMTGGGFGGCV
IALAPVQRAEAIGHAVRRAATQAGFAQPVVTRTRAAAGAGPCR
>Mature_362_residues
TVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVASFTRADDDAITVVSDRADAPVRIPIDTGPGDVTGWAAYPAGVMWA
LRTAGHPVPGGVMSITSDVPMGSGLSSSAALECAVLGAISSAAGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYGR
PATAVLIDFADLAVTPVAFDPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASSLREAADRGCTDLAAVRDA
VDARRARHVLTENRRVIDCVAALNNSDYPEAGRIFTASHASMRDDFGITTERIDLIADTALRAGALGARMTGGGFGGCVI
ALAPVQRAEAIGHAVRRAATQAGFAQPVVTRTRAAAGAGPCR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=353, Percent_Identity=39.0934844192635, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1786972, Length=361, Percent_Identity=36.8421052631579, Blast_Score=218, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6319494, Length=275, Percent_Identity=29.8181818181818, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320212, Length=276, Percent_Identity=28.6231884057971, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24661292, Length=391, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355577, Length=391, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24661285, Length=391, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 37592; Mature: 37461

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVASFTRADDDAITVVSDRADAPVRIP
CEEEECCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCEEEE
IDTGPGDVTGWAAYPAGVMWALRTAGHPVPGGVMSITSDVPMGSGLSSSAALECAVLGAI
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
SSAAGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYGRPATAVLIDFADLAVTPVAF
HCCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHEEECEEE
DPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASSLREAADRGCTDLAAVRD
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHH
AVDARRARHVLTENRRVIDCVAALNNSDYPEAGRIFTASHASMRDDFGITTERIDLIADT
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
ALRAGALGARMTGGGFGGCVIALAPVQRAEAIGHAVRRAATQAGFAQPVVTRTRAAAGAG
HHHHCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
PCR
CCC
>Mature Secondary Structure 
TVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVASFTRADDDAITVVSDRADAPVRIP
EEEECCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCEEEE
IDTGPGDVTGWAAYPAGVMWALRTAGHPVPGGVMSITSDVPMGSGLSSSAALECAVLGAI
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
SSAAGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYGRPATAVLIDFADLAVTPVAF
HCCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHEEECEEE
DPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASSLREAADRGCTDLAAVRD
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHH
AVDARRARHVLTENRRVIDCVAALNNSDYPEAGRIFTASHASMRDDFGITTERIDLIADT
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
ALRAGALGARMTGGGFGGCVIALAPVQRAEAIGHAVRRAATQAGFAQPVVTRTRAAAGAG
HHHHCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
PCR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]