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The map label for this gene is ethA [H]

Identifier: 41410160

GI number: 41410160

Start: 4523634

End: 4525154

Strand: Reverse

Name: ethA [H]

Synonym: MAP4062c

Alternate gene names: 41410160

Gene position: 4525154-4523634 (Counterclockwise)

Preceding gene: 41410161

Following gene: 41410159

Centisome position: 93.69

GC content: 67.32

Gene sequence:

>1521_bases
ATGACCGTGACTCCCCAGGAAGCCGCCGACCACGGCGCGGCCGAGGCCGACTATTTCGACGTCCTGATCGTCGGCGCCGG
GATCTCCGGCATCGACGCGGCCTACCGGATCACCGAGCGCAATCCGCAGCTGAGCTACGCGATCCTGGAGCGGCGCGCGC
GGATCGGCGGGACGTGGGACCTGTTCCGCTACCCCGGTGTGCGCTCGGACAGCAGCATCTTCACGCTGTCCTTCCCATTC
GAGCCGTGGACCCGCAAAGAGGGCGTGGCCGACGGGGTGCACATCCGCGAGTACCTCACCGCCACCGCGCACAAGTACGG
CATCGACCGCCACATCCGGTTCAACAGCTACGTGCGCTCGGCGGACTGGGACTCGACCAGCGACACCTGGACGGTCACCG
TCGAAGACGGGGCGCGGGACGGCGAACGCAAGCTCTACCGCGCTCGCTTCCTGTTCTTCGGCAGCGGCTACTACAACTAC
GACGAGGGCTACACCCCCGACTTCCCGGGCATCGAGGAGTTCACCGGCACCGTGGTGCACCCCCAGCACTGGCCCGAGGA
CCTCGACTACACGGGCAAGAAGGTGGTGGTGATCGGCAGCGGGGCGACCGCGGTCACGCTGCTGCCGTCGCTGAGCGACC
GCGCCGCCAAGGTGACCATGCTGCAACGCTCCCCCACCTACCTGATCTCGGCGTCCAAGTACGGCAAGGTCGCCGCGGTG
GCGCGAAAAGTGTTGCCCCGCAAGCCCGCTCATCTCGTTATCCGGATGTACAGCGCACTGACCGAGGCGGTGTTCTTCGC
GCTGTCCCGCAAGGCACCGCGGCTGGTGCGCTGGCTGCTGCGCCGCAAGGCGATCAACAGCCTGCCCCCCGGCTACGCCG
TCGACATTCACTTCAAGCCGCGCTACAACCCGTGGGACCAGCGGATGTGCCTGATCCCCGATGCCGACCTGTACAACGCC
ATCACCGCCGGGCGCGCCGACGTGGTCACCGACCACATCGACCACTTCGACGCCACCGGCATCGCGCTGCGGTCCGGTGC
CCACCTGGACGCCGACATCATCATCACCGCCACCGGCCTGCAATTGCAGGCCCTCGGCGGGGCCACGATCAGCCTGGACG
GCAACGAGATCAAGACCAACGACCGGTTCGTCTACAAGGCGCACATGCTCGAAGACGTGCCCAACCTGTTCTGGTGTGTG
GGCTACACCAACGCGTCGTGGACGCTGCGGGCCGACATCACCGCCCGGGCGACGGCAAAACTGTTGGAGCACATGACGAC
TCACGGCTACACGCACGCCTACCCACATCGCGGCAACGAGCCGATGACCGAGAAGCCGTCGTGGGACATCAACGCCGGGT
ATGTACTGCGCTCGGTGCACGCGCTGCCGAAGTCGGGCACCAAGCGGCCCTGGAACGTGCGGCAGAACTACCTCGCCGAC
GCCATCGACTACCGCTTCGACCGCATCGAAGAGGCGATGGTGTTCGGCCGGGCCGCCGACCGGGCGGCGCTGGCCGGCTG
A

Upstream 100 bases:

>100_bases
GATTCCCGGCGCACGAACGTGAGCGCGGCCGTTCACTAGCCCAACCAACCGGTGGGTCTCTACCCTGGTGACCAGTCCCA
CAATTCGAGCGAGGTTCGCG

Downstream 100 bases:

>100_bases
TCGGCGGGCGCCGGGGCGAGTTGGTGAATTCCTTCTAAAACTCAGATGTCGGCAATACGCTGATCGCCATGGCAGCTCAG
ATGCGTGAACCCAAAGTCGT

Product: hypothetical protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILERRARIGGTWDLFRYPGVRSDSSIFTLSFPF
EPWTRKEGVADGVHIREYLTATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDGERKLYRARFLFFGSGYYNY
DEGYTPDFPGIEEFTGTVVHPQHWPEDLDYTGKKVVVIGSGATAVTLLPSLSDRAAKVTMLQRSPTYLISASKYGKVAAV
ARKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVDIHFKPRYNPWDQRMCLIPDADLYNA
ITAGRADVVTDHIDHFDATGIALRSGAHLDADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPNLFWCV
GYTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNEPMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLAD
AIDYRFDRIEEAMVFGRAADRAALAG

Sequences:

>Translated_506_residues
MTVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILERRARIGGTWDLFRYPGVRSDSSIFTLSFPF
EPWTRKEGVADGVHIREYLTATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDGERKLYRARFLFFGSGYYNY
DEGYTPDFPGIEEFTGTVVHPQHWPEDLDYTGKKVVVIGSGATAVTLLPSLSDRAAKVTMLQRSPTYLISASKYGKVAAV
ARKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVDIHFKPRYNPWDQRMCLIPDADLYNA
ITAGRADVVTDHIDHFDATGIALRSGAHLDADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPNLFWCV
GYTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNEPMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLAD
AIDYRFDRIEEAMVFGRAADRAALAG
>Mature_505_residues
TVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILERRARIGGTWDLFRYPGVRSDSSIFTLSFPFE
PWTRKEGVADGVHIREYLTATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDGERKLYRARFLFFGSGYYNYD
EGYTPDFPGIEEFTGTVVHPQHWPEDLDYTGKKVVVIGSGATAVTLLPSLSDRAAKVTMLQRSPTYLISASKYGKVAAVA
RKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVDIHFKPRYNPWDQRMCLIPDADLYNAI
TAGRADVVTDHIDHFDATGIALRSGAHLDADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPNLFWCVG
YTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNEPMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLADA
IDYRFDRIEEAMVFGRAADRAALAG

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=223, Percent_Identity=26.9058295964126, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI50541961, Length=223, Percent_Identity=26.9058295964126, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25145785, Length=379, Percent_Identity=24.0105540897098, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561948, Length=376, Percent_Identity=24.2021276595745, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506045, Length=257, Percent_Identity=26.0700389105058, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56672; Mature: 56540

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILERRARIGGTWD
CCCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEE
LFRYPGVRSDSSIFTLSFPFEPWTRKEGVADGVHIREYLTATAHKYGIDRHIRFNSYVRS
HHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCEEEC
ADWDSTSDTWTVTVEDGARDGERKLYRARFLFFGSGYYNYDEGYTPDFPGIEEFTGTVVH
CCCCCCCCEEEEEECCCCCCCHHHHEEEEEEEEECCEEECCCCCCCCCCCHHHHCCCEEC
PQHWPEDLDYTGKKVVVIGSGATAVTLLPSLSDRAAKVTMLQRSPTYLISASKYGKVAAV
CCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCHHHHH
ARKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVDIHFKP
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
RYNPWDQRMCLIPDADLYNAITAGRADVVTDHIDHFDATGIALRSGAHLDADIIITATGL
CCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCE
QLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADITARATAK
EEEEECCEEEEECCCEEECCCEEEEEHHHHHCCCCEEEEEEECCCCEEEEECCHHHHHHH
LLEHMTTHGYTHAYPHRGNEPMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLAD
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
AIDYRFDRIEEAMVFGRAADRAALAG
HHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
TVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILERRARIGGTWD
CCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEE
LFRYPGVRSDSSIFTLSFPFEPWTRKEGVADGVHIREYLTATAHKYGIDRHIRFNSYVRS
HHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCEEEC
ADWDSTSDTWTVTVEDGARDGERKLYRARFLFFGSGYYNYDEGYTPDFPGIEEFTGTVVH
CCCCCCCCEEEEEECCCCCCCHHHHEEEEEEEEECCEEECCCCCCCCCCCHHHHCCCEEC
PQHWPEDLDYTGKKVVVIGSGATAVTLLPSLSDRAAKVTMLQRSPTYLISASKYGKVAAV
CCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCHHHHH
ARKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVDIHFKP
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
RYNPWDQRMCLIPDADLYNAITAGRADVVTDHIDHFDATGIALRSGAHLDADIIITATGL
CCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCE
QLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADITARATAK
EEEEECCEEEEECCCEEECCCEEEEEHHHHHCCCCEEEEEEECCCCEEEEECCHHHHHHH
LLEHMTTHGYTHAYPHRGNEPMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLAD
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
AIDYRFDRIEEAMVFGRAADRAALAG
HHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA