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The map label for this gene is fabG [C]

Identifier: 41410031

GI number: 41410031

Start: 4393539

End: 4394477

Strand: Reverse

Name: fabG [C]

Synonym: MAP3933c

Alternate gene names: 41410031

Gene position: 4394477-4393539 (Counterclockwise)

Preceding gene: 41410032

Following gene: 41410030

Centisome position: 90.99

GC content: 71.78

Gene sequence:

>939_bases
ATGGCTCCCCACGACAAACAGCACCGCGACTGGTCGGAGGCCGACGTTGGTGATCAGAGCGGCCGCGTCGTCGTCATCAC
CGGCGCCAACACCGGCATCGGCTACGAGACGGCCGCCGTGCTGGCCCACCGCGGCGCCCACGTCGTGCTCGCGGTCCGCG
ACCTGGAGAAGGGCAACGCGGCGCTGTCGCGGATCGTGGCCGCCAGCCCGAACGCCGACGTCACGCTGCAGCAGCTGGAC
CTGGCCTCGCTGGCCTCGGTGCGTTCGGCCGCCGAGGCGCTGCGCGCGGCCTACCCGCGCATCGACCTGCTGATCAACAA
CGCCGGCGTGATGTGGACGCCCAAGCAGGTCACCGAGGACGGTTTCGAATTGCAGTTCGGCACCAACCATCTGGGGCACT
TCGCGCTGACCGGGTTGCTGCTCGATCACCTGCTGGGAGTGCGGGATTCGCGGGTGGTGACGGTCAGCAGCCTCGGCCAC
CGGCTGCGCGCGGCCATCCACTTCGACGACCTGCACTGGGAGCGCCGCTACGACCGGGTCGCCGCCTACGGCCAGTCCAA
GCTGGCCAACCTGCTGTTCACCTACGAGCTGCAGCGCCGGCTGGCGGCCGCCCCGGACGCGAAGACCATCGCGGTCGCCG
CGCACCCCGGCGGCTCCAACACCGAGCTGGCCCGCCACCTGCCCGGCATCTTCCGGCCGGTGCAGGCGGTGCTGGGGCCG
GTGCTGTTCCAGAGCCCGGCGATGGGCGCGCTGCCGACGCTGCGGGCCGCCACCGATCCGGCCGTGCAGGGCGGGCAGTA
CTACGGCCCGGACGGCTTCCTCGAACAGCGCGGGCGCCCGAAGCTGGTCGAGTCCAGCGCCCAGTCGCACGACGAGCAGC
TGCAGCGCCGGCTGTGGGCCGTGTCCGAAGAACTCACCGGCGTCCACTTCCCGGTCTGA

Upstream 100 bases:

>100_bases
CTGGCCGACATGACCGACGAGGAACGCCGGGAATGGTTCGCCCGGCACGACAACTTCTGGGTTCAATAGCGCGTCCCGGT
CGGTGAGTATGTTGTGGGCC

Downstream 100 bases:

>100_bases
CCTCCATGGCCGCGATGCGCTCCGTCGCCGAACACCAGCGGGTGGTGGCCGGGCTGATCCGCGCCCGGCCGCCGGTCGCG
GTGCCGCTGGCGCAGGCCCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAPHDKQHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVLAVRDLEKGNAALSRIVAASPNADVTLQQLD
LASLASVRSAAEALRAAYPRIDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGVRDSRVVTVSSLGH
RLRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGP
VLFQSPAMGALPTLRAATDPAVQGGQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWAVSEELTGVHFPV

Sequences:

>Translated_312_residues
MAPHDKQHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVLAVRDLEKGNAALSRIVAASPNADVTLQQLD
LASLASVRSAAEALRAAYPRIDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGVRDSRVVTVSSLGH
RLRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGP
VLFQSPAMGALPTLRAATDPAVQGGQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWAVSEELTGVHFPV
>Mature_311_residues
APHDKQHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVLAVRDLEKGNAALSRIVAASPNADVTLQQLDL
ASLASVRSAAEALRAAYPRIDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGVRDSRVVTVSSLGHR
LRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGPV
LFQSPAMGALPTLRAATDPAVQGGQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWAVSEELTGVHFPV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=299, Percent_Identity=45.819397993311, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI166795268, Length=290, Percent_Identity=42.0689655172414, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI10190746, Length=313, Percent_Identity=38.9776357827476, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI186928839, Length=292, Percent_Identity=41.4383561643836, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI193804850, Length=293, Percent_Identity=39.9317406143345, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI19923931, Length=265, Percent_Identity=44.1509433962264, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI7706523, Length=300, Percent_Identity=37.6666666666667, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI146231950, Length=301, Percent_Identity=38.8704318936877, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI7705421, Length=257, Percent_Identity=27.6264591439689, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI13375997, Length=197, Percent_Identity=29.9492385786802, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI72534732, Length=187, Percent_Identity=29.9465240641711, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=296, Percent_Identity=32.7702702702703, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17532805, Length=305, Percent_Identity=34.0983606557377, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193207620, Length=307, Percent_Identity=31.5960912052117, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17532791, Length=304, Percent_Identity=32.5657894736842, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71992402, Length=300, Percent_Identity=34, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17535059, Length=300, Percent_Identity=32.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72001364, Length=255, Percent_Identity=34.1176470588235, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17505416, Length=304, Percent_Identity=27.9605263157895, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI115533174, Length=299, Percent_Identity=30.4347826086957, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI115533172, Length=299, Percent_Identity=30.4347826086957, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI32565532, Length=210, Percent_Identity=32.3809523809524, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324820, Length=320, Percent_Identity=27.8125, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28573296, Length=298, Percent_Identity=42.6174496644295, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI22024069, Length=298, Percent_Identity=42.9530201342282, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI19921754, Length=298, Percent_Identity=42.2818791946309, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24586328, Length=296, Percent_Identity=42.2297297297297, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI161076371, Length=295, Percent_Identity=40.6779661016949, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45554248, Length=253, Percent_Identity=46.2450592885375, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24640117, Length=253, Percent_Identity=46.2450592885375, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24656154, Length=276, Percent_Identity=36.231884057971, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19922628, Length=276, Percent_Identity=36.231884057971, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45553409, Length=251, Percent_Identity=36.6533864541833, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24647948, Length=251, Percent_Identity=36.6533864541833, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24647946, Length=253, Percent_Identity=36.3636363636364, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI20129347, Length=300, Percent_Identity=35.6666666666667, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24647931, Length=328, Percent_Identity=32.0121951219512, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21357041, Length=208, Percent_Identity=30.2884615384615, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33779; Mature: 33647

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPHDKQHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVLAVRDLEKGNA
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHH
ALSRIVAASPNADVTLQQLDLASLASVRSAAEALRAAYPRIDLLINNAGVMWTPKQVTED
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEECCHHHCCC
GFELQFGTNHLGHFALTGLLLDHLLGVRDSRVVTVSSLGHRLRAAIHFDDLHWERRYDRV
CCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHEEEEHHHHHHHHHHHH
AAYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGP
HHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCHHHHHHHHHHHH
VLFQSPAMGALPTLRAATDPAVQGGQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWA
HHHCCCCCCCCCCHHCCCCCCCCCCCEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VSEELTGVHFPV
HHHHHCCCCCCC
>Mature Secondary Structure 
APHDKQHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVLAVRDLEKGNA
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHH
ALSRIVAASPNADVTLQQLDLASLASVRSAAEALRAAYPRIDLLINNAGVMWTPKQVTED
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEECCHHHCCC
GFELQFGTNHLGHFALTGLLLDHLLGVRDSRVVTVSSLGHRLRAAIHFDDLHWERRYDRV
CCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHEEEEHHHHHHHHHHHH
AAYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGP
HHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCHHHHHHHHHHHH
VLFQSPAMGALPTLRAATDPAVQGGQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWA
HHHCCCCCCCCCCHHCCCCCCCCCCCEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VSEELTGVHFPV
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]