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The map label for this gene is thiD

Identifier: 41410010

GI number: 41410010

Start: 4374635

End: 4375483

Strand: Reverse

Name: thiD

Synonym: MAP3912c

Alternate gene names: 41410010

Gene position: 4375483-4374635 (Counterclockwise)

Preceding gene: 41410011

Following gene: 41410009

Centisome position: 90.59

GC content: 72.32

Gene sequence:

>849_bases
GTGACGGGGCCGCCGCCGACGCTGCCACTGGCGCCGCCGGGCACCACGCCGCGCCGGGTGCTGTCCATCGCCGGATCCGA
CTCCGGGGGTGGTGCGGGCATCCAGGCCGACCTGCGCACCATGGCGATGCTGGGCGTGCACGCCTGCGTCGCCGTGACCG
CGGTGACCGTGCAGAACACGTTGGGGGTCAACAGCTTTCACGAGGTGCCCGCCGACGTGGTGGCCGGCCAGATCGAGGCG
GTCGCCGGCGACATCGGCATCCAGGCGGCCAAGACCGGCATGCTGGCGTCCTCGCCCATCATCGCCGAGGTGGCCGCGAC
CTGGCGCCGGCTGGAGTTGTCGGTGCCGCTGGTGGTCGACCCGGTGTGCGCGTCCATGCACGGTGACCCGCTGCTGGCCG
CCGACGCGCTGGACACCCTGCGCGGCCAATTGTTCCCGCTGGCCACCCTGGTGACGCCGAACCTCGACGAGGTCCGGCTG
CTGGTGGACATCGACGTGACCGATGCCGCGTCGCAGCGGGCTGCGGCCAAGGCCCTGCACGCGCTGGGGCCGCAATGGGT
GCTGGTCAAGGGCGGGCATCTGCGGTCGTCGCAACGCAGCTGTGACCTGCTCTACGACGGCGACTCGTGCTACGAGTTCG
ACGCGCACCGGCTGGCCACCGGCAACGACCACGGCGGCGGCGACACGCTGGCCAGTGCCGTCGCCTGTGCGCTCGCGCAC
GGCTTCACCGTGCCGGATGCGGTCGCCTTCGGAAAGCGTTGGGTCACCGAGTGTTTGCGCGCCTCCTACCCGCTGGGCCA
CGGCCACGGCCCCGTCTCCGCCTTGTTCCGGCTCTCGGGGGACGGATGA

Upstream 100 bases:

>100_bases
AGCACGGGCTGGACAGCGAGGAAGCGATCGAGGCGGCCATGGCCGACAAGTCTCGCGAGTTCGCCGAGCACGGCAACCGG
GTGTATCTACCGCTGGCACA

Downstream 100 bases:

>100_bases
ACCTCGACCGGATCGCGGGCATCGCCCACCGGCCCGACGGCACCCCCGAAGGCGTGGTGGTGCTCACCCACGGCGCCGGC
GGCAACCGGGATTCGCCACT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTGPPPTLPLAPPGTTPRRVLSIAGSDSGGGAGIQADLRTMAMLGVHACVAVTAVTVQNTLGVNSFHEVPADVVAGQIEA
VAGDIGIQAAKTGMLASSPIIAEVAATWRRLELSVPLVVDPVCASMHGDPLLAADALDTLRGQLFPLATLVTPNLDEVRL
LVDIDVTDAASQRAAAKALHALGPQWVLVKGGHLRSSQRSCDLLYDGDSCYEFDAHRLATGNDHGGGDTLASAVACALAH
GFTVPDAVAFGKRWVTECLRASYPLGHGHGPVSALFRLSGDG

Sequences:

>Translated_282_residues
MTGPPPTLPLAPPGTTPRRVLSIAGSDSGGGAGIQADLRTMAMLGVHACVAVTAVTVQNTLGVNSFHEVPADVVAGQIEA
VAGDIGIQAAKTGMLASSPIIAEVAATWRRLELSVPLVVDPVCASMHGDPLLAADALDTLRGQLFPLATLVTPNLDEVRL
LVDIDVTDAASQRAAAKALHALGPQWVLVKGGHLRSSQRSCDLLYDGDSCYEFDAHRLATGNDHGGGDTLASAVACALAH
GFTVPDAVAFGKRWVTECLRASYPLGHGHGPVSALFRLSGDG
>Mature_281_residues
TGPPPTLPLAPPGTTPRRVLSIAGSDSGGGAGIQADLRTMAMLGVHACVAVTAVTVQNTLGVNSFHEVPADVVAGQIEAV
AGDIGIQAAKTGMLASSPIIAEVAATWRRLELSVPLVVDPVCASMHGDPLLAADALDTLRGQLFPLATLVTPNLDEVRLL
VDIDVTDAASQRAAAKALHALGPQWVLVKGGHLRSSQRSCDLLYDGDSCYEFDAHRLATGNDHGGGDTLASAVACALAHG
FTVPDAVAFGKRWVTECLRASYPLGHGHGPVSALFRLSGDG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=255, Percent_Identity=39.6078431372549, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325378, Length=265, Percent_Identity=32.4528301886792, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324997, Length=264, Percent_Identity=32.9545454545455, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324517, Length=264, Percent_Identity=32.9545454545455, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28972; Mature: 28841

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPPPTLPLAPPGTTPRRVLSIAGSDSGGGAGIQADLRTMAMLGVHACVAVTAVTVQNT
CCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVNSFHEVPADVVAGQIEAVAGDIGIQAAKTGMLASSPIIAEVAATWRRLELSVPLVVD
CCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHEECCCEEEC
PVCASMHGDPLLAADALDTLRGQLFPLATLVTPNLDEVRLLVDIDVTDAASQRAAAKALH
HHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
ALGPQWVLVKGGHLRSSQRSCDLLYDGDSCYEFDAHRLATGNDHGGGDTLASAVACALAH
HCCCCEEEEECCCCCCCCCCCCEEECCCCCEECCCCEECCCCCCCCHHHHHHHHHHHHHC
GFTVPDAVAFGKRWVTECLRASYPLGHGHGPVSALFRLSGDG
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCC
>Mature Secondary Structure 
TGPPPTLPLAPPGTTPRRVLSIAGSDSGGGAGIQADLRTMAMLGVHACVAVTAVTVQNT
CCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVNSFHEVPADVVAGQIEAVAGDIGIQAAKTGMLASSPIIAEVAATWRRLELSVPLVVD
CCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHEECCCEEEC
PVCASMHGDPLLAADALDTLRGQLFPLATLVTPNLDEVRLLVDIDVTDAASQRAAAKALH
HHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
ALGPQWVLVKGGHLRSSQRSCDLLYDGDSCYEFDAHRLATGNDHGGGDTLASAVACALAH
HCCCCEEEEECCCCCCCCCCCCEEECCCCCEECCCCEECCCCCCCCHHHHHHHHHHHHHC
GFTVPDAVAFGKRWVTECLRASYPLGHGHGPVSALFRLSGDG
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]