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The map label for this gene is fadE7

Identifier: 41409976

GI number: 41409976

Start: 4340136

End: 4341332

Strand: Reverse

Name: fadE7

Synonym: MAP3878c

Alternate gene names: 41409976

Gene position: 4341332-4340136 (Counterclockwise)

Preceding gene: 41409977

Following gene: 41409975

Centisome position: 89.89

GC content: 69.42

Gene sequence:

>1197_bases
ATGAGCACCGAGACGAGCACCAAGACCCCACCGTCCTTCGACCGCTACGACCCGCTGGGCCTGGACGCCTTGCTGTCCGA
CGACGAACGCGCGGTGCGCGACACCGTGCGGGGTTTCTGCGCCGAGCACGTGCTGCCGCACGTGGCGGAGTGGTTCGAGA
TCGGCGACCTGCCGGTCCGCGAACTGGCCAGGGAGTTCGGCCGGCTCGGCCTGCTGGGCATGCACCTGCACGGCTACGGC
TGCGGCGGCGCGTCGGCCGTGCACTACGGGCTGGCCTGCGTGGAGCTGGAGGCCGCCGACTCCGGTCTGCGTTCGATGGT
CTCGGTGCAGGGCTCGCTGGCGATGTTCGCGATCTGGAACTTCGGCTCCGAGGAGCAAAAACGCCAATGGCTGCCGGGCA
TGGCCACCGGCGAACTGCTCGGCTGCTTCGGGCTGACCGAGCCCGACGTCGGCTCCGACCCCGCGGCGATGAAAACCCGT
GCGCGACGGGATGGTTCGGACTGGGTGCTCGATGGCCGCAAGCTGTGGATCACCAACGGGTCGGTGGCCGACGTCGCCGT
GGTGTGGGCCGGCACCGACGACGGCATCCGCGGCTTCCTGGTGCCCACCGACACGCCGGGTTTCACCGCCAACACGATTC
ACCACAAGCTGTCGCTGCGTGCCTCGATCACCAGCGAGCTGGTGCTCGACGACGTGCGGCTGCCCGGCGAGGCGATGCTG
CCCGGAGCCACCGGGCTGCGCGGCCCGCTGTCGTGTCTGTCCGAGGCCCGCTACGGGATCATCTGGGGCGCAAGGGGCGC
GGCGCGCTCGGCCTGGCAGGCCGCCCTGGATTACGCCACCCAGCGCACCCAGTTCGGCCGCCCCATCGCCGGATTCCAGC
TGACCCAGGCCAAGCTCGTCGACATGGCCGTCGAGCTGCACAAGGGCCAGCTGTTGTCGCTGCATCTGGGCCGCCTCAAG
GACAGCACCGGGCTGCGGCCCGAGCAGGTCAGCTTCGGCAAGCTCAACAACACCCGGGAGGCGATCGAGATCTGCCGGAC
CGCGCGAACCATCCTGGGCGGCAACGGGATATCGCTGGAATACCCCGTCATCCGGCACATGGTGAACCTGGAATCGGTGC
TGACCTACGAGGGCACGCCGGAGATGCATCAGCTCGTCCTCGGCCAGGCATTCACCGGCGCCGACGCCTTCCGCTGA

Upstream 100 bases:

>100_bases
TCGCCGCGGCGGTGCTGTTCTTCGCCTCGCAGGCAGCCTCGTTCGTCACCGGACAGGTGATCAGTGTCAGCGGCGGCTTA
ACGATGGCAGGCTGACTGCT

Downstream 100 bases:

>100_bases
CCCAGAGCAGCACCCGATGGCCGCACACCTGCAGTACACCTCCGAGCATCACCAGTTCCGGGAGCTGGTCCGCGATTTCG
TGCAACGGACGGTCGTGCCC

Product: FadE7

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSTETSTKTPPSFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAEWFEIGDLPVRELAREFGRLGLLGMHLHGYG
CGGASAVHYGLACVELEAADSGLRSMVSVQGSLAMFAIWNFGSEEQKRQWLPGMATGELLGCFGLTEPDVGSDPAAMKTR
ARRDGSDWVLDGRKLWITNGSVADVAVVWAGTDDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAML
PGATGLRGPLSCLSEARYGIIWGARGAARSAWQAALDYATQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLK
DSTGLRPEQVSFGKLNNTREAIEICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGADAFR

Sequences:

>Translated_398_residues
MSTETSTKTPPSFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAEWFEIGDLPVRELAREFGRLGLLGMHLHGYG
CGGASAVHYGLACVELEAADSGLRSMVSVQGSLAMFAIWNFGSEEQKRQWLPGMATGELLGCFGLTEPDVGSDPAAMKTR
ARRDGSDWVLDGRKLWITNGSVADVAVVWAGTDDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAML
PGATGLRGPLSCLSEARYGIIWGARGAARSAWQAALDYATQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLK
DSTGLRPEQVSFGKLNNTREAIEICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGADAFR
>Mature_397_residues
STETSTKTPPSFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAEWFEIGDLPVRELAREFGRLGLLGMHLHGYGC
GGASAVHYGLACVELEAADSGLRSMVSVQGSLAMFAIWNFGSEEQKRQWLPGMATGELLGCFGLTEPDVGSDPAAMKTRA
RRDGSDWVLDGRKLWITNGSVADVAVVWAGTDDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAMLP
GATGLRGPLSCLSEARYGIIWGARGAARSAWQAALDYATQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKD
STGLRPEQVSFGKLNNTREAIEICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGADAFR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=400, Percent_Identity=50.25, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI7669494, Length=380, Percent_Identity=50, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=35.752688172043, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4501857, Length=391, Percent_Identity=31.9693094629156, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=29.1005291005291, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4557231, Length=394, Percent_Identity=28.6802030456853, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI187960098, Length=394, Percent_Identity=28.6802030456853, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=30.2452316076294, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=28.9473684210526, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=28.7323943661972, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=29.144385026738, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=29.144385026738, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI7656849, Length=386, Percent_Identity=26.4248704663212, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI38505218, Length=383, Percent_Identity=25.3263707571802, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=24.8251748251748, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=24.8251748251748, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=317, Percent_Identity=27.7602523659306, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081958, Length=318, Percent_Identity=27.6729559748428, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=46.6321243523316, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=32.9787234042553, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=29.3963254593176, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=385, Percent_Identity=30.9090909090909, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=30.5039787798408, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=388, Percent_Identity=29.8969072164948, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=361, Percent_Identity=29.9168975069252, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17533517, Length=383, Percent_Identity=26.6318537859008, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=26.3157894736842, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71990804, Length=258, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=271, Percent_Identity=31.3653136531365, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=33.4782608695652, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=277, Percent_Identity=27.4368231046931, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=29.6028880866426, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17505929, Length=300, Percent_Identity=27.3333333333333, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=284, Percent_Identity=25.3521126760563, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920834, Length=404, Percent_Identity=49.7524752475247, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=32.0754716981132, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24666513, Length=369, Percent_Identity=31.4363143631436, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=30.9333333333333, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=30.5483028720627, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=30.1587301587302, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI281363737, Length=395, Percent_Identity=26.5822784810127, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43119; Mature: 42987

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTETSTKTPPSFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAEWFEIGDLPVR
CCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELAREFGRLGLLGMHLHGYGCGGASAVHYGLACVELEAADSGLRSMVSVQGSLAMFAIWN
HHHHHHCCCCEEEEEEECCCCCCHHHHHHCEEEEEEHHHHHHHHHHHHHCCCEEEEEEEC
FGSEEQKRQWLPGMATGELLGCFGLTEPDVGSDPAAMKTRARRDGSDWVLDGRKLWITNG
CCCHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCEEEEEECC
SVADVAVVWAGTDDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAML
CEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCC
PGATGLRGPLSCLSEARYGIIWGARGAARSAWQAALDYATQRTQFGRPIAGFQLTQAKLV
CCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
DMAVELHKGQLLSLHLGRLKDSTGLRPEQVSFGKLNNTREAIEICRTARTILGGNGISLE
HHHHHHCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEC
YPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGADAFR
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STETSTKTPPSFDRYDPLGLDALLSDDERAVRDTVRGFCAEHVLPHVAEWFEIGDLPVR
CCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELAREFGRLGLLGMHLHGYGCGGASAVHYGLACVELEAADSGLRSMVSVQGSLAMFAIWN
HHHHHHCCCCEEEEEEECCCCCCHHHHHHCEEEEEEHHHHHHHHHHHHHCCCEEEEEEEC
FGSEEQKRQWLPGMATGELLGCFGLTEPDVGSDPAAMKTRARRDGSDWVLDGRKLWITNG
CCCHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCEEEEEECC
SVADVAVVWAGTDDGIRGFLVPTDTPGFTANTIHHKLSLRASITSELVLDDVRLPGEAML
CEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCC
PGATGLRGPLSCLSEARYGIIWGARGAARSAWQAALDYATQRTQFGRPIAGFQLTQAKLV
CCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
DMAVELHKGQLLSLHLGRLKDSTGLRPEQVSFGKLNNTREAIEICRTARTILGGNGISLE
HHHHHHCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEC
YPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGADAFR
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]