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The map label for this gene is czcD [H]

Identifier: 41409963

GI number: 41409963

Start: 4326696

End: 4327592

Strand: Reverse

Name: czcD [H]

Synonym: MAP3865c

Alternate gene names: 41409963

Gene position: 4327592-4326696 (Counterclockwise)

Preceding gene: 41409964

Following gene: 41409961

Centisome position: 89.6

GC content: 72.13

Gene sequence:

>897_bases
ATGGGCGCCGGCCACAACCACACCCCCGCCGAGACGGGTGACGCCCGGCTGATCCCGCGGATGGTGATGGCCGCGGCGAT
CCTGGCGGCGTTCTTCGTCGTCGAGCTGGTCACCTCGTTGCTGATCAACTCGATCGCGCTGTTGGCCGACGCGGGCCACA
TGCTGACCGACGTCGTCGCGGTGTTCATGGGGTTGGCCGCCGTCACGCTGGCCCGCCGGGGCAGCTCGTCGCCGGCGCGC
ACCTATGGCTGGCACCGCGCCGAGGTGTTCACCGCCGTCGCCAACGCCGGGCTGCTGATCGGCGTCTCGGTGTTCATCCT
CTACGAGGCGATCCAGCGGCTGCGCGAGGCTCCCGCCGTGCCGGGCGTGCCGATGATCGCGGTGGCACTGGCCGGGCTGG
CCGCCAACTTCGTCGTCGCGCTGCTGCTGCGCTCGCACTCGTCGGGCAGCCTGGCCGTCAAGGGCGCCTACCTGGAGGTC
ATCGCCGACACCGTCGGCAGCCTGGGCGTGCTGATCGCCGGGGTGGTCACGGTGACCACGCGCTGGCCCTACGCCGACGT
GGTGGTGGCCGTGCTGGTGGCGCTGTGGGTGCTGCCCCGGGCCATCTCGCTGGCCCGCGACGCACTGCGGATCCTGTCCG
AATCCTCACCCACCCACATCGACGTCGAGGAGCTGCGCGCCGCGCTGGGCGCCGTTGACGGCGTGACCGGCGTGCACGAC
CTGCACGTGTGGACGCTGTCGCCGGGCAAGGACATGTGCACCGCGCACCTGATCAGCACCGGCGACTCCGCCCGGGTGCT
GCGCGACGCCCGCGCCGTGCTCTCGGCCCGCGGGCTCGCCCACGCCACCGTGCAGATCGACTGCCCGGACGACACCGAGT
GCTCCGACAGCTTCTGA

Upstream 100 bases:

>100_bases
CCGCACTGGCTGGCCGGCGCGGGCAACGTGCTGACCCGCTTCTGGAGCCGCTGGGTCTGACCCTTGCAATATATGCGTTG
CCATGCATATATTGCCCGGC

Downstream 100 bases:

>100_bases
AAAGCCTTACAGCCCAAGCTCTTTGCGTGCTGCGGGGTCGCAATCGTCGAGCAGGTCCAGGCAGCGCAGGTACTCGTCGG
TCTCGCCGATCGTGTCGGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGAGHNHTPAETGDARLIPRMVMAAAILAAFFVVELVTSLLINSIALLADAGHMLTDVVAVFMGLAAVTLARRGSSSPAR
TYGWHRAEVFTAVANAGLLIGVSVFILYEAIQRLREAPAVPGVPMIAVALAGLAANFVVALLLRSHSSGSLAVKGAYLEV
IADTVGSLGVLIAGVVTVTTRWPYADVVVAVLVALWVLPRAISLARDALRILSESSPTHIDVEELRAALGAVDGVTGVHD
LHVWTLSPGKDMCTAHLISTGDSARVLRDARAVLSARGLAHATVQIDCPDDTECSDSF

Sequences:

>Translated_298_residues
MGAGHNHTPAETGDARLIPRMVMAAAILAAFFVVELVTSLLINSIALLADAGHMLTDVVAVFMGLAAVTLARRGSSSPAR
TYGWHRAEVFTAVANAGLLIGVSVFILYEAIQRLREAPAVPGVPMIAVALAGLAANFVVALLLRSHSSGSLAVKGAYLEV
IADTVGSLGVLIAGVVTVTTRWPYADVVVAVLVALWVLPRAISLARDALRILSESSPTHIDVEELRAALGAVDGVTGVHD
LHVWTLSPGKDMCTAHLISTGDSARVLRDARAVLSARGLAHATVQIDCPDDTECSDSF
>Mature_297_residues
GAGHNHTPAETGDARLIPRMVMAAAILAAFFVVELVTSLLINSIALLADAGHMLTDVVAVFMGLAAVTLARRGSSSPART
YGWHRAEVFTAVANAGLLIGVSVFILYEAIQRLREAPAVPGVPMIAVALAGLAANFVVALLLRSHSSGSLAVKGAYLEVI
ADTVGSLGVLIAGVVTVTTRWPYADVVVAVLVALWVLPRAISLARDALRILSESSPTHIDVEELRAALGAVDGVTGVHDL
HVWTLSPGKDMCTAHLISTGDSARVLRDARAVLSARGLAHATVQIDCPDDTECSDSF

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=302, Percent_Identity=29.1390728476821, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI52352805, Length=303, Percent_Identity=27.0627062706271, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI21361112, Length=306, Percent_Identity=29.7385620915033, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI64762489, Length=319, Percent_Identity=26.9592476489028, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI289803013, Length=295, Percent_Identity=27.1186440677966, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI289803009, Length=295, Percent_Identity=27.1186440677966, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI289803007, Length=295, Percent_Identity=27.1186440677966, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI289803003, Length=295, Percent_Identity=27.1186440677966, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI20070323, Length=321, Percent_Identity=25.2336448598131, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=38.5826771653543, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI52352803, Length=132, Percent_Identity=40.9090909090909, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI14210520, Length=207, Percent_Identity=27.0531400966184, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786966, Length=282, Percent_Identity=36.8794326241135, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17555794, Length=314, Percent_Identity=30.8917197452229, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=313, Percent_Identity=30.0319488817891, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193210990, Length=312, Percent_Identity=29.1666666666667, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32564488, Length=310, Percent_Identity=24.1935483870968, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=133, Percent_Identity=35.3383458646617, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=119, Percent_Identity=37.8151260504202, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=164, Percent_Identity=28.6585365853659, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24583858, Length=329, Percent_Identity=27.355623100304, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656728, Length=340, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656724, Length=340, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656720, Length=340, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656715, Length=340, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357035, Length=340, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585900, Length=148, Percent_Identity=29.0540540540541, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585898, Length=148, Percent_Identity=29.0540540540541, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585896, Length=148, Percent_Identity=29.0540540540541, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921672, Length=148, Percent_Identity=29.0540540540541, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=33.9449541284404, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=28.169014084507, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=28.169014084507, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 31064; Mature: 30933

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGHNHTPAETGDARLIPRMVMAAAILAAFFVVELVTSLLINSIALLADAGHMLTDVVA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
VFMGLAAVTLARRGSSSPARTYGWHRAEVFTAVANAGLLIGVSVFILYEAIQRLREAPAV
HHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
PGVPMIAVALAGLAANFVVALLLRSHSSGSLAVKGAYLEVIADTVGSLGVLIAGVVTVTT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
RWPYADVVVAVLVALWVLPRAISLARDALRILSESSPTHIDVEELRAALGAVDGVTGVHD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCCEE
LHVWTLSPGKDMCTAHLISTGDSARVLRDARAVLSARGLAHATVQIDCPDDTECSDSF
EEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GAGHNHTPAETGDARLIPRMVMAAAILAAFFVVELVTSLLINSIALLADAGHMLTDVVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
VFMGLAAVTLARRGSSSPARTYGWHRAEVFTAVANAGLLIGVSVFILYEAIQRLREAPAV
HHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
PGVPMIAVALAGLAANFVVALLLRSHSSGSLAVKGAYLEVIADTVGSLGVLIAGVVTVTT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
RWPYADVVVAVLVALWVLPRAISLARDALRILSESSPTHIDVEELRAALGAVDGVTGVHD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCCEE
LHVWTLSPGKDMCTAHLISTGDSARVLRDARAVLSARGLAHATVQIDCPDDTECSDSF
EEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]