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The map label for this gene is cobB1 [H]

Identifier: 41408358

GI number: 41408358

Start: 2524540

End: 2525388

Strand: Direct

Name: cobB1 [H]

Synonym: MAP2260

Alternate gene names: 41408358

Gene position: 2524540-2525388 (Clockwise)

Preceding gene: 41408357

Following gene: 41408360

Centisome position: 52.27

GC content: 69.26

Gene sequence:

>849_bases
GTGACGGTCGGCCGCGCGGAATCCCCGGAACTGGTGGCGGTGCTGGCCGGTCGGCGGATCGCGGTACTGACCGGTGCGGG
CATCTCCACCGACTCGGGCATTCCGGACTACCGCGGGCCCGAGTCGCCGCCCAGCAATCCGATGACGATCCGCCAGTTCA
CCGGCGATCCGGCGTTCCGGCAGCGGTACTGGGCGCGCAACCACGTCGGCTGGCGGCACATGGACGACACGCTGCCCAAC
GCCGGCCACCGGGCGCTGGCCACGCTCGAGGATGCAGCGGTGGTCACCGGCGTGATCACCCAGAACGTCGACCTGCTGCA
TACCAAGGCGGGCAGCCGAAACGTCATCGACCTGCACGGCAGCTACGCGCGGGTGATCTGCCTGGGCTGCGGTGACACCA
CGAGCCGCGCCGCGTTGGCCGAGCGGCTGGAAGCGCTCAACCCGGGGTTCATCGAGCGCACCGAGGCGATCGGCGGGCTG
GCGGTGGCCCCCGACGCCGACGCGGTCGTCGCCGACACCGCGTCGTTCCGTTATCTGGACTGCGCGCGCTGCGCCGGCAT
GCTCAAGCCCGACATCGTCTATTTCGGCGAGAGCGTGCCCAAAGATGTTGTGGCAGCTGCCTATCGGCTCATCGACGAGT
CCGATGCGCTGCTGGTCGCGGGGTCGTCGCTGACCGTGTTCTCCGGCTACCGGTTCGTGCGTCATGCCGCCGCCCGGGGC
ATCCCTATCGCGATCGTCAACCGCGGCGACACCCGGGGCGACCACTTGGCCACCGTCAAGATCGACGGCGGGTGTTCGGA
GTTACTGACCCTGCTCGCCGACGAGTTATCGCCGCTGCCAACGCATTAG

Upstream 100 bases:

>100_bases
CCGAGCTGGGCGCGGCGGCCTGCAAGATGATGGAGCAGAACATGTCCGCCGAGCTGACGACGGCGGCGGGCTGCCTCGGC
TGACTCGTACCCTGAACAAC

Downstream 100 bases:

>100_bases
CGCCACACGCGTCAGAAGGTGCAGGGCATGGCGCGGATGGCGTGCACGAAATTGCCCGCCAGGTAGGTGGGCTCGCCGGC
CTGGATGCCGGGCAGCTGCC

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPESPPSNPMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPN
AGHRALATLEDAAVVTGVITQNVDLLHTKAGSRNVIDLHGSYARVICLGCGDTTSRAALAERLEALNPGFIERTEAIGGL
AVAPDADAVVADTASFRYLDCARCAGMLKPDIVYFGESVPKDVVAAAYRLIDESDALLVAGSSLTVFSGYRFVRHAAARG
IPIAIVNRGDTRGDHLATVKIDGGCSELLTLLADELSPLPTH

Sequences:

>Translated_282_residues
MTVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPESPPSNPMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPN
AGHRALATLEDAAVVTGVITQNVDLLHTKAGSRNVIDLHGSYARVICLGCGDTTSRAALAERLEALNPGFIERTEAIGGL
AVAPDADAVVADTASFRYLDCARCAGMLKPDIVYFGESVPKDVVAAAYRLIDESDALLVAGSSLTVFSGYRFVRHAAARG
IPIAIVNRGDTRGDHLATVKIDGGCSELLTLLADELSPLPTH
>Mature_281_residues
TVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPESPPSNPMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPNA
GHRALATLEDAAVVTGVITQNVDLLHTKAGSRNVIDLHGSYARVICLGCGDTTSRAALAERLEALNPGFIERTEAIGGLA
VAPDADAVVADTASFRYLDCARCAGMLKPDIVYFGESVPKDVVAAAYRLIDESDALLVAGSSLTVFSGYRFVRHAAARGI
PIAIVNRGDTRGDHLATVKIDGGCSELLTLLADELSPLPTH

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=266, Percent_Identity=45.4887218045113, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI6912664, Length=262, Percent_Identity=30.1526717557252, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI300795542, Length=261, Percent_Identity=29.1187739463602, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13787215, Length=244, Percent_Identity=31.1475409836066, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI300797577, Length=255, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI308199517, Length=265, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990482, Length=258, Percent_Identity=41.4728682170543, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71990487, Length=260, Percent_Identity=41.1538461538462, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17567771, Length=256, Percent_Identity=37.5, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17541892, Length=265, Percent_Identity=25.2830188679245, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28571445, Length=268, Percent_Identity=45.1492537313433, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28571443, Length=225, Percent_Identity=45.7777777777778, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI28571441, Length=225, Percent_Identity=45.7777777777778, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI17137536, Length=265, Percent_Identity=28.6792452830189, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 29943; Mature: 29812

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPESPPSNPMTIRQFTGDPAFR
CCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
QRYWARNHVGWRHMDDTLPNAGHRALATLEDAAVVTGVITQNVDLLHTKAGSRNVIDLHG
HHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECC
SYARVICLGCGDTTSRAALAERLEALNPGFIERTEAIGGLAVAPDADAVVADTASFRYLD
CEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCEEEECCCCCCCHH
CARCAGMLKPDIVYFGESVPKDVVAAAYRLIDESDALLVAGSSLTVFSGYRFVRHAAARG
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHHHCC
IPIAIVNRGDTRGDHLATVKIDGGCSELLTLLADELSPLPTH
CCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPESPPSNPMTIRQFTGDPAFR
CCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
QRYWARNHVGWRHMDDTLPNAGHRALATLEDAAVVTGVITQNVDLLHTKAGSRNVIDLHG
HHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECC
SYARVICLGCGDTTSRAALAERLEALNPGFIERTEAIGGLAVAPDADAVVADTASFRYLD
CEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCEEEECCCCCCCHH
CARCAGMLKPDIVYFGESVPKDVVAAAYRLIDESDALLVAGSSLTVFSGYRFVRHAAARG
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHHHCC
IPIAIVNRGDTRGDHLATVKIDGGCSELLTLLADELSPLPTH
CCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]