| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is limC [H]
Identifier: 41407549
GI number: 41407549
Start: 1586428
End: 1587276
Strand: Direct
Name: limC [H]
Synonym: MAP1451
Alternate gene names: 41407549
Gene position: 1586428-1587276 (Clockwise)
Preceding gene: 41407540
Following gene: 41407552
Centisome position: 32.85
GC content: 69.61
Gene sequence:
>849_bases ATGCCACAAGTCAGTGCCGCAGGGCGGCTGGCGGGGAAGGTCGCGTTGATCACGGGCGCGGCGCGGGGAATCGGGCGCGC CCAAGCCGTGCGGTTCGCGCAGGAGGGCGCCGACATCGTGGCCCTCGACCTGTGCGGGCCGGTCGACACGGTGATGGTTC CGCCCAGCACACCCGACGATCTCGACCACACGGCCTCGCTGGTCGGCGAGGTGGGCGGGCGAATGCACGCGGAGCTCGTC GACGTTCGTGACCTCGATGGCGTTCAGGCCGCCACCGAGCGCGGTGCGCGACGGTTCGGCGGGTTGGACGTGGTCTGCGC GACCGCCGGCATCACGTCGCGCGCGATGACGGTCGAGATGGACGAGAGCGTCTGGCGCACCATGCTCGACGTGAACCTCA CCGGCGTATGGCACACGTGCCGCGCCGCCGCGCCGCATCTGATCGCACGCGGTGCCGGTTCGATGATCTTGACGAATTCC ATTGCGGGACTGCGTGGTCTGGTCGGCGTCGCGCACTACACCGCCGCCAAGCACGGCGTGGTCGGCCTGATGCAGAGCCT GGCCCACGAACTCGCGCCGCACCGGGTGCGCGTTAACTGCGTGCACCCGACCAACGTCGACACGCCGTTGATCCAAAACG ACACCGTACGAAGCGCGTTTCGGCCCGACCTGGATCGGCCGCCGACGCGAGCCGAGTTCGCCGAAGCGGCGCGAGCGATG AACCTGCTTCAGGTGCCGTGGGTCGATCCGGTCGACGTCGCCAATGCCGCGCTGTTCCTGGCCTCCGACGAGGCGCGTTA CATCACCGCCGTGACCCTGCCGGTCGACGCGGGCGCCACTCAGCGATAG
Upstream 100 bases:
>100_bases TCGGCCGGGATATCCCGGTGACCGGTACGCCGGCATGATCGTCTCCCGGCCATCGGACACACACCGACCCCGGTGCCGCC CGCGCCGGCAGAATCGCCGG
Downstream 100 bases:
>100_bases GAGGATTCGTGACCGACGTTGCGAAGTGCGGGGTGCCTGCCGGGCACCGAATCAGCCGCGCGAAAGGAAGGCCAGCACGG TGCTTTCGAACGCCTCTTTG
Product: hypothetical protein
Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]
Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]
Number of amino acids: Translated: 282; Mature: 281
Protein sequence:
>282_residues MPQVSAAGRLAGKVALITGAARGIGRAQAVRFAQEGADIVALDLCGPVDTVMVPPSTPDDLDHTASLVGEVGGRMHAELV DVRDLDGVQAATERGARRFGGLDVVCATAGITSRAMTVEMDESVWRTMLDVNLTGVWHTCRAAAPHLIARGAGSMILTNS IAGLRGLVGVAHYTAAKHGVVGLMQSLAHELAPHRVRVNCVHPTNVDTPLIQNDTVRSAFRPDLDRPPTRAEFAEAARAM NLLQVPWVDPVDVANAALFLASDEARYITAVTLPVDAGATQR
Sequences:
>Translated_282_residues MPQVSAAGRLAGKVALITGAARGIGRAQAVRFAQEGADIVALDLCGPVDTVMVPPSTPDDLDHTASLVGEVGGRMHAELV DVRDLDGVQAATERGARRFGGLDVVCATAGITSRAMTVEMDESVWRTMLDVNLTGVWHTCRAAAPHLIARGAGSMILTNS IAGLRGLVGVAHYTAAKHGVVGLMQSLAHELAPHRVRVNCVHPTNVDTPLIQNDTVRSAFRPDLDRPPTRAEFAEAARAM NLLQVPWVDPVDVANAALFLASDEARYITAVTLPVDAGATQR >Mature_281_residues PQVSAAGRLAGKVALITGAARGIGRAQAVRFAQEGADIVALDLCGPVDTVMVPPSTPDDLDHTASLVGEVGGRMHAELVD VRDLDGVQAATERGARRFGGLDVVCATAGITSRAMTVEMDESVWRTMLDVNLTGVWHTCRAAAPHLIARGAGSMILTNSI AGLRGLVGVAHYTAAKHGVVGLMQSLAHELAPHRVRVNCVHPTNVDTPLIQNDTVRSAFRPDLDRPPTRAEFAEAARAMN LLQVPWVDPVDVANAALFLASDEARYITAVTLPVDAGATQR
Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=282, Percent_Identity=34.7517730496454, Blast_Score=112, Evalue=5e-25, Organism=Homo sapiens, GI32483357, Length=275, Percent_Identity=29.8181818181818, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI40254992, Length=266, Percent_Identity=29.3233082706767, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI66933014, Length=272, Percent_Identity=27.2058823529412, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI4504505, Length=222, Percent_Identity=30.1801801801802, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI7705925, Length=273, Percent_Identity=31.5018315018315, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI40254986, Length=198, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI126723750, Length=278, Percent_Identity=28.0575539568345, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI59889578, Length=202, Percent_Identity=33.6633663366337, Blast_Score=85, Evalue=9e-17, Organism=Homo sapiens, GI126723191, Length=195, Percent_Identity=30.2564102564103, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI40807363, Length=211, Percent_Identity=26.0663507109005, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI4758504, Length=212, Percent_Identity=32.0754716981132, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI25282469, Length=254, Percent_Identity=29.1338582677165, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI5031737, Length=281, Percent_Identity=27.0462633451957, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI33667109, Length=215, Percent_Identity=29.7674418604651, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI210032110, Length=212, Percent_Identity=25, Blast_Score=75, Evalue=9e-14, Organism=Homo sapiens, GI19923817, Length=277, Percent_Identity=25.6317689530686, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI10190704, Length=269, Percent_Identity=26.3940520446097, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI142976729, Length=208, Percent_Identity=24.5192307692308, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI7706318, Length=210, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI302344755, Length=104, Percent_Identity=33.6538461538462, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=25.2873563218391, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI223718074, Length=204, Percent_Identity=30.3921568627451, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI310128830, Length=224, Percent_Identity=25.4464285714286, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI310115468, Length=224, Percent_Identity=25.4464285714286, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI83715985, Length=194, Percent_Identity=31.9587628865979, Blast_Score=69, Evalue=4e-12, Organism=Escherichia coli, GI1789208, Length=284, Percent_Identity=32.0422535211268, Blast_Score=132, Evalue=2e-32, Organism=Escherichia coli, GI87082100, Length=277, Percent_Identity=32.4909747292419, Blast_Score=130, Evalue=9e-32, Organism=Escherichia coli, GI1787335, Length=272, Percent_Identity=30.8823529411765, Blast_Score=117, Evalue=1e-27, Organism=Escherichia coli, GI87082160, Length=276, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1790717, Length=270, Percent_Identity=29.2592592592593, Blast_Score=89, Evalue=2e-19, Organism=Escherichia coli, GI1787905, Length=278, Percent_Identity=25.1798561151079, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI1788459, Length=267, Percent_Identity=28.0898876404494, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1786812, Length=274, Percent_Identity=28.1021897810219, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1787526, Length=275, Percent_Identity=26.9090909090909, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1789378, Length=266, Percent_Identity=25.9398496240602, Blast_Score=75, Evalue=5e-15, Organism=Escherichia coli, GI1788891, Length=185, Percent_Identity=32.972972972973, Blast_Score=67, Evalue=2e-12, Organism=Escherichia coli, GI2367175, Length=275, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI2367365, Length=202, Percent_Identity=28.2178217821782, Blast_Score=62, Evalue=3e-11, Organism=Caenorhabditis elegans, GI25147288, Length=272, Percent_Identity=30.5147058823529, Blast_Score=112, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17555706, Length=271, Percent_Identity=30.9963099630996, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17568967, Length=223, Percent_Identity=30.4932735426009, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17560676, Length=279, Percent_Identity=28.3154121863799, Blast_Score=95, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17564282, Length=218, Percent_Identity=27.9816513761468, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI71994600, Length=269, Percent_Identity=28.6245353159851, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI71982365, Length=199, Percent_Identity=29.1457286432161, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17544670, Length=287, Percent_Identity=27.8745644599303, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17561402, Length=282, Percent_Identity=26.241134751773, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17567345, Length=209, Percent_Identity=26.7942583732057, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI71994604, Length=279, Percent_Identity=28.3154121863799, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562910, Length=287, Percent_Identity=27.8745644599303, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562908, Length=287, Percent_Identity=28.2229965156794, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17562904, Length=283, Percent_Identity=25.4416961130742, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562906, Length=289, Percent_Identity=28.3737024221453, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17560150, Length=282, Percent_Identity=26.241134751773, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI193203117, Length=205, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI193203115, Length=202, Percent_Identity=24.7524752475248, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17558628, Length=206, Percent_Identity=29.126213592233, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17560220, Length=289, Percent_Identity=28.0276816608997, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17508895, Length=208, Percent_Identity=25.9615384615385, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17559104, Length=286, Percent_Identity=28.6713286713287, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17538182, Length=233, Percent_Identity=30.0429184549356, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17563726, Length=282, Percent_Identity=26.9503546099291, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17555612, Length=275, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17551412, Length=286, Percent_Identity=24.1258741258741, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17562990, Length=282, Percent_Identity=24.822695035461, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193204405, Length=289, Percent_Identity=26.643598615917, Blast_Score=66, Evalue=3e-11, Organism=Caenorhabditis elegans, GI32563809, Length=236, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=8e-11, Organism=Caenorhabditis elegans, GI17507613, Length=236, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=33.8461538461538, Blast_Score=97, Evalue=3e-21, Organism=Saccharomyces cerevisiae, GI6324126, Length=271, Percent_Identity=26.1992619926199, Blast_Score=76, Evalue=6e-15, Organism=Drosophila melanogaster, GI24644339, Length=271, Percent_Identity=32.8413284132841, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24639444, Length=277, Percent_Identity=29.6028880866426, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI18859837, Length=221, Percent_Identity=32.579185520362, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI21355319, Length=276, Percent_Identity=27.1739130434783, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI23397609, Length=273, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=5e-19, Organism=Drosophila melanogaster, GI21357041, Length=272, Percent_Identity=29.7794117647059, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI28571526, Length=267, Percent_Identity=29.5880149812734, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI24640492, Length=210, Percent_Identity=27.1428571428571, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI21357673, Length=224, Percent_Identity=27.6785714285714, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=26.5873015873016, Blast_Score=84, Evalue=8e-17, Organism=Drosophila melanogaster, GI281364892, Length=240, Percent_Identity=27.5, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI24643142, Length=201, Percent_Identity=31.8407960199005, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI21355631, Length=184, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24581726, Length=236, Percent_Identity=24.5762711864407, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24644337, Length=182, Percent_Identity=29.1208791208791, Blast_Score=68, Evalue=8e-12, Organism=Drosophila melanogaster, GI116007234, Length=232, Percent_Identity=28.0172413793103, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI21358495, Length=223, Percent_Identity=25.5605381165919, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI21356301, Length=210, Percent_Identity=25.2380952380952, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.125 [C]
Molecular weight: Translated: 29697; Mature: 29566
Theoretical pI: Translated: 6.42; Mature: 6.42
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPQVSAAGRLAGKVALITGAARGIGRAQAVRFAQEGADIVALDLCGPVDTVMVPPSTPDD CCCCCCCHHHHCEEEEEECCHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCC LDHTASLVGEVGGRMHAELVDVRDLDGVQAATERGARRFGGLDVVCATAGITSRAMTVEM HHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEE DESVWRTMLDVNLTGVWHTCRAAAPHLIARGAGSMILTNSIAGLRGLVGVAHYTAAKHGV HHHHHHHHHHCCCCHHHHHHHHHCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH VGLMQSLAHELAPHRVRVNCVHPTNVDTPLIQNDTVRSAFRPDLDRPPTRAEFAEAARAM HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHH NLLQVPWVDPVDVANAALFLASDEARYITAVTLPVDAGATQR HHHCCCCCCCHHHCCEEEEEECCCCEEEEEEEEEECCCCCCC >Mature Secondary Structure PQVSAAGRLAGKVALITGAARGIGRAQAVRFAQEGADIVALDLCGPVDTVMVPPSTPDD CCCCCCHHHHCEEEEEECCHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCC LDHTASLVGEVGGRMHAELVDVRDLDGVQAATERGARRFGGLDVVCATAGITSRAMTVEM HHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEE DESVWRTMLDVNLTGVWHTCRAAAPHLIARGAGSMILTNSIAGLRGLVGVAHYTAAKHGV HHHHHHHHHHCCCCHHHHHHHHHCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH VGLMQSLAHELAPHRVRVNCVHPTNVDTPLIQNDTVRSAFRPDLDRPPTRAEFAEAARAM HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHH NLLQVPWVDPVDVANAALFLASDEARYITAVTLPVDAGATQR HHHCCCCCCCHHHCCEEEEEECCCCEEEEEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+ [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 15.4 {2-deoxygluconate}} [C]
Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]
Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10473585 [H]