Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 41407540

GI number: 41407540

Start: 1576324

End: 1577211

Strand: Direct

Name: fabG [C]

Synonym: MAP1442

Alternate gene names: 41407540

Gene position: 1576324-1577211 (Clockwise)

Preceding gene: 41407539

Following gene: 41407549

Centisome position: 32.64

GC content: 66.78

Gene sequence:

>888_bases
ATGAGCCGCTTACTGTCCGGCAAAACGGCGTTGGTCACCGGTAGCAGCCGCGGCATAGGTCGCGCGGTCGCGCAGCGCCT
GGCCGCCGCGGGGGCCACGGTCGCGGTGACCGCACGCTCGCACTCGTCGTCCCTATCGACGCGGGCCGGTACGGCCACCG
CGCTGCCCGGCACCATCGGCGAAACGATCGAACTGATTGAAGCCGCCGGTGGTTCGGCGTTCGGGATCGCGGCCGACCTC
GAAGACGCCGACCAGCGGGACGGTTTGGTCGATGCGGTCCTCGACCGCACGGGCCGCATCGACATTCTGGTCAACAACGC
CGGTTTCGCCGACTACTCGTTGGTCGAAGACATGAGTTTGGAAACGTTCGATCGCACCGTGGAGCACTACCTTCGCGTCC
CGTTCGTCCTGACGAAATGCGCTGTGCCGCATATGCGCAAGCAAGGGGCGGGGTGGATCGTCAACATCGGATCGGTCACG
GGCGTGGCCCCGGTCAGGCCGTACCGGGAGTACAACAAGGCCTCCGGCGACGTGGTCTACGCGGCCATGAAAGCCGCCCT
GCACCGGTTCACCCAGGGAGTGGCCGCCGAGTTGCTCGACGCCAGCATCGCCGTGAACTGCGTCGGCCCGTCGACGGCGG
TCCGGACACCCGGTGCCGCGCAACTGATCCCGGAGTCTTTCCCTACCGAACCGGTGGAGTATCTGGCCGAGACCGTGCTG
GCGATGTGCCATCTGCCCGCCGCGGAGCGAACAGGGCTGGTCGCGTTCAGCCTGCATTATCCGTGGTCACAGCAGCTACC
CGTGCACAGCCTGGACGGCGCGAACCTGTTGCCGCCGTTGCGTCCCCCGGCAAATGCCAATCCGAACATTCTTCCCGCGG
GGGTCTAG

Upstream 100 bases:

>100_bases
ACCGCTCGGGCGGAGGCCGGATCGTGACCGCGTTCCCCTATCGCCTCGTCGATTTCTGGCGCGACCATCGTGCGCCGAGC
GAGGAAGATCTCGAGTTGCG

Downstream 100 bases:

>100_bases
GTCAGAACCGGATCGGTGCTGATGCAGAAGCTGTGGCAGACGCGGTCGCGCACGATGACGTCGGGACACTCCGGGTCGAA
CCAACGGTCCACCACCGCCC

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSLSTRAGTATALPGTIGETIELIEAAGGSAFGIAADL
EDADQRDGLVDAVLDRTGRIDILVNNAGFADYSLVEDMSLETFDRTVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVT
GVAPVRPYREYNKASGDVVYAAMKAALHRFTQGVAAELLDASIAVNCVGPSTAVRTPGAAQLIPESFPTEPVEYLAETVL
AMCHLPAAERTGLVAFSLHYPWSQQLPVHSLDGANLLPPLRPPANANPNILPAGV

Sequences:

>Translated_295_residues
MSRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSLSTRAGTATALPGTIGETIELIEAAGGSAFGIAADL
EDADQRDGLVDAVLDRTGRIDILVNNAGFADYSLVEDMSLETFDRTVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVT
GVAPVRPYREYNKASGDVVYAAMKAALHRFTQGVAAELLDASIAVNCVGPSTAVRTPGAAQLIPESFPTEPVEYLAETVL
AMCHLPAAERTGLVAFSLHYPWSQQLPVHSLDGANLLPPLRPPANANPNILPAGV
>Mature_294_residues
SRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSLSTRAGTATALPGTIGETIELIEAAGGSAFGIAADLE
DADQRDGLVDAVLDRTGRIDILVNNAGFADYSLVEDMSLETFDRTVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVTG
VAPVRPYREYNKASGDVVYAAMKAALHRFTQGVAAELLDASIAVNCVGPSTAVRTPGAAQLIPESFPTEPVEYLAETVLA
MCHLPAAERTGLVAFSLHYPWSQQLPVHSLDGANLLPPLRPPANANPNILPAGV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=207, Percent_Identity=31.4009661835749, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI40254986, Length=212, Percent_Identity=30.6603773584906, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4504505, Length=264, Percent_Identity=29.5454545454545, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI126723191, Length=206, Percent_Identity=31.0679611650485, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI7706318, Length=195, Percent_Identity=32.3076923076923, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=27.2373540856031, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI31542939, Length=237, Percent_Identity=28.2700421940928, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40254992, Length=233, Percent_Identity=29.1845493562232, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33667109, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI126723750, Length=240, Percent_Identity=27.9166666666667, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI5031737, Length=210, Percent_Identity=28.0952380952381, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI20149619, Length=212, Percent_Identity=26.8867924528302, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI7705925, Length=221, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=206, Percent_Identity=33.0097087378641, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082100, Length=278, Percent_Identity=29.8561151079137, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367175, Length=205, Percent_Identity=35.1219512195122, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=210, Percent_Identity=32.8571428571429, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=29.1338582677165, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788459, Length=290, Percent_Identity=27.2413793103448, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789208, Length=206, Percent_Identity=28.1553398058252, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367365, Length=206, Percent_Identity=29.6116504854369, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=235, Percent_Identity=34.0425531914894, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193204405, Length=240, Percent_Identity=34.1666666666667, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562906, Length=230, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=213, Percent_Identity=36.150234741784, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=216, Percent_Identity=34.7222222222222, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=235, Percent_Identity=34.0425531914894, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531453, Length=213, Percent_Identity=35.6807511737089, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=213, Percent_Identity=30.0469483568075, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=221, Percent_Identity=33.4841628959276, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=228, Percent_Identity=32.4561403508772, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982365, Length=219, Percent_Identity=31.5068493150685, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=210, Percent_Identity=30, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=213, Percent_Identity=32.3943661971831, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=217, Percent_Identity=33.6405529953917, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=243, Percent_Identity=27.5720164609054, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86565303, Length=266, Percent_Identity=31.9548872180451, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=212, Percent_Identity=32.5471698113208, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17558628, Length=217, Percent_Identity=33.1797235023041, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=273, Percent_Identity=27.4725274725275, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=214, Percent_Identity=32.7102803738318, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=217, Percent_Identity=31.3364055299539, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17555612, Length=234, Percent_Identity=31.6239316239316, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=257, Percent_Identity=29.5719844357977, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=214, Percent_Identity=31.7757009345794, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71997099, Length=279, Percent_Identity=28.673835125448, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=219, Percent_Identity=30.5936073059361, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=225, Percent_Identity=30.2222222222222, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=205, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=273, Percent_Identity=26.007326007326, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=240, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=215, Percent_Identity=29.3023255813954, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=238, Percent_Identity=26.890756302521, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=25.9803921568627, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=210, Percent_Identity=36.1904761904762, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI21357041, Length=208, Percent_Identity=35.0961538461538, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21357673, Length=213, Percent_Identity=32.3943661971831, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28571526, Length=208, Percent_Identity=34.1346153846154, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24644339, Length=210, Percent_Identity=32.3809523809524, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI18859837, Length=283, Percent_Identity=29.3286219081272, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=25, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30831; Mature: 30700

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSLSTRAGTATALPGTIG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCHH
ETIELIEAAGGSAFGIAADLEDADQRDGLVDAVLDRTGRIDILVNNAGFADYSLVEDMSL
HHHHHHHHCCCCEEEEEECCCCCHHHCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCH
ETFDRTVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVTGVAPVRPYREYNKASGDVVY
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCCCCCCCCCCHHHHCCCCCHHHH
AAMKAALHRFTQGVAAELLDASIAVNCVGPSTAVRTPGAAQLIPESFPTEPVEYLAETVL
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
AMCHLPAAERTGLVAFSLHYPWSQQLPVHSLDGANLLPPLRPPANANPNILPAGV
HHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCC
>Mature Secondary Structure 
SRLLSGKTALVTGSSRGIGRAVAQRLAAAGATVAVTARSHSSSLSTRAGTATALPGTIG
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCHH
ETIELIEAAGGSAFGIAADLEDADQRDGLVDAVLDRTGRIDILVNNAGFADYSLVEDMSL
HHHHHHHHCCCCEEEEEECCCCCHHHCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCH
ETFDRTVEHYLRVPFVLTKCAVPHMRKQGAGWIVNIGSVTGVAPVRPYREYNKASGDVVY
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCCCCCCCCCCHHHHCCCCCHHHH
AAMKAALHRFTQGVAAELLDASIAVNCVGPSTAVRTPGAAQLIPESFPTEPVEYLAETVL
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
AMCHLPAAERTGLVAFSLHYPWSQQLPVHSLDGANLLPPLRPPANANPNILPAGV
HHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]