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The map label for this gene is ppnK

Identifier: 41407500

GI number: 41407500

Start: 1513899

End: 1514825

Strand: Direct

Name: ppnK

Synonym: MAP1402

Alternate gene names: 41407500

Gene position: 1513899-1514825 (Clockwise)

Preceding gene: 41407499

Following gene: 41407501

Centisome position: 31.35

GC content: 70.55

Gene sequence:

>927_bases
GTGACCCCCGCCGAGCGCACCGTCCTGATGGTGGTCCACACCGGCCGCGAAGAAGCAACCGAGACGGCACGCCGAGTACA
GAAGGTGCTGGGCGACAACGGGATTGCGCTGCGGGTGCTGTCCGCCGAGGCGGTCGACCGGGGGCCGCTGCACCTGGCGC
CCGACGACATGCGGGCCATGGGCGTCGAGATCGAGGTGGTCGACGCCGACCCGCTGGCCGCCCGCGGCTGCGAGCTGGTG
CTGGTCCTCGGCGGCGACGGCACGTTTCTGCGGGCCGCGGAATTGGCGCGCAACGCCGACATCCCGGTGCTCGGCGTCAA
CCTCGGCCGGATCGGTTTCTTGGCCGAGGCCGAAGCCGAGGCGATCGATAAGGTGCTGGAACACGTTGTGGCGCGCGACT
ATCGGGTGGAGAACCGGATGACGCTCGACGTCGTGGTGCGCCATCAGGGCACGGTGTCCGACCACGGCTGGGCGCTCAAC
GAAGTCAGCCTGGAAAAAGGCCCGCGGCTCGGGGTGCTCGGGGTGGTGGTCGAGATCGACGGCCGGCCGGTGTCGGCCTT
CGGCTGCGACGGCGTGCTGGTGTCGACGCCCACCGGATCCACCGCGTACGCGTTCTCCGCGGGCGGCCCGGTGCTCTGGC
CCGACCTGGAGGCAATCCTGGTGGTGCCCAACAACGCTCACGCGCTGTTCGGCCGGCCCATGGTCACCAGTCCGGCCGCC
ACCATCGCGATCGAGATCGAGGCCGACGGCCACGACGCCCTGGTGTTCTGCGACGGTCGCCGCGAGATGCTGATACCGGC
CGGCAGCCGGATCGAGGTCAAACGGTGTGACACCGCGGTGAAGTGGGCCCGGCTGGACAGCGCCCCGTTCACCGACCGGC
TGGTGCGCAAGTTCCGGCTTCCGGTGACCGGGTGGCGCGGCAACTGA

Upstream 100 bases:

>100_bases
ACGTCGAATACTTCCTGCGGCTGCGCGCCCGCACCGACCGCCCGCTGGCCGGCGACGCGCTGTGCCGCGCGGTGCGGCGC
GCGGTGGAAAGCGGACCGCA

Downstream 100 bases:

>100_bases
CGGCGCGAACGGGATTGCGACTGCCATGCTGACCGAAATCCGCATCGAGTCACTGGGGGCGATCAGCGCCGCGGTCGGGG
AGTTCGACCGCGGCCTGACC

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTPAERTVLMVVHTGREEATETARRVQKVLGDNGIALRVLSAEAVDRGPLHLAPDDMRAMGVEIEVVDADPLAARGCELV
LVLGGDGTFLRAAELARNADIPVLGVNLGRIGFLAEAEAEAIDKVLEHVVARDYRVENRMTLDVVVRHQGTVSDHGWALN
EVSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPAA
TIAIEIEADGHDALVFCDGRREMLIPAGSRIEVKRCDTAVKWARLDSAPFTDRLVRKFRLPVTGWRGN

Sequences:

>Translated_308_residues
MTPAERTVLMVVHTGREEATETARRVQKVLGDNGIALRVLSAEAVDRGPLHLAPDDMRAMGVEIEVVDADPLAARGCELV
LVLGGDGTFLRAAELARNADIPVLGVNLGRIGFLAEAEAEAIDKVLEHVVARDYRVENRMTLDVVVRHQGTVSDHGWALN
EVSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPAA
TIAIEIEADGHDALVFCDGRREMLIPAGSRIEVKRCDTAVKWARLDSAPFTDRLVRKFRLPVTGWRGN
>Mature_307_residues
TPAERTVLMVVHTGREEATETARRVQKVLGDNGIALRVLSAEAVDRGPLHLAPDDMRAMGVEIEVVDADPLAARGCELVL
VLGGDGTFLRAAELARNADIPVLGVNLGRIGFLAEAEAEAIDKVLEHVVARDYRVENRMTLDVVVRHQGTVSDHGWALNE
VSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPAAT
IAIEIEADGHDALVFCDGRREMLIPAGSRIEVKRCDTAVKWARLDSAPFTDRLVRKFRLPVTGWRGN

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=223, Percent_Identity=31.390134529148, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788968, Length=249, Percent_Identity=32.9317269076305, Blast_Score=128, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320794, Length=238, Percent_Identity=27.7310924369748, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325068, Length=172, Percent_Identity=32.5581395348837, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322509, Length=246, Percent_Identity=27.2357723577236, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573830, Length=215, Percent_Identity=28.8372093023256, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077047, Length=215, Percent_Identity=28.8372093023256, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573832, Length=215, Percent_Identity=28.8372093023256, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573828, Length=215, Percent_Identity=28.8372093023256, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573826, Length=215, Percent_Identity=28.8372093023256, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281363323, Length=240, Percent_Identity=28.75, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281363321, Length=240, Percent_Identity=28.75, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI20129957, Length=240, Percent_Identity=28.75, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653422, Length=240, Percent_Identity=28.75, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653424, Length=240, Percent_Identity=28.75, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_MYCPA (Q740E9)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960336.1
- ProteinModelPortal:   Q740E9
- SMR:   Q740E9
- EnsemblBacteria:   EBMYCT00000037439
- GeneID:   2717587
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1402
- NMPDR:   fig|262316.1.peg.1402
- GeneTree:   EBGT00050000016530
- HOGENOM:   HBG713904
- OMA:   CVPEGFD
- ProtClustDB:   PRK03372
- BRENDA:   2.7.1.23
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 33029; Mature: 32898

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAERTVLMVVHTGREEATETARRVQKVLGDNGIALRVLSAEAVDRGPLHLAPDDMRAM
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCHHHC
GVEIEVVDADPLAARGCELVLVLGGDGTFLRAAELARNADIPVLGVNLGRIGFLAEAEAE
CEEEEEECCCCCCCCCCEEEEEECCCCCEEHHHHHHCCCCCCEEEECCCCEEEEECCHHH
AIDKVLEHVVARDYRVENRMTLDVVVRHQGTVSDHGWALNEVSLEKGPRLGVLGVVVEID
HHHHHHHHHHHCCEECCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEEEEEEC
GRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPAA
CEEEEEECCCEEEEECCCCCEEEEEECCCCEECCCCEEEEEECCCCCEEECCCEECCCCE
TIAIEIEADGHDALVFCDGRREMLIPAGSRIEVKRCDTAVKWARLDSAPFTDRLVRKFRL
EEEEEEEECCCEEEEEECCCCEEEECCCCEEEEECCCCHHEEEECCCCCHHHHHHHHHCC
PVTGWRGN
CCCCCCCC
>Mature Secondary Structure 
TPAERTVLMVVHTGREEATETARRVQKVLGDNGIALRVLSAEAVDRGPLHLAPDDMRAM
CCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCHHHC
GVEIEVVDADPLAARGCELVLVLGGDGTFLRAAELARNADIPVLGVNLGRIGFLAEAEAE
CEEEEEECCCCCCCCCCEEEEEECCCCCEEHHHHHHCCCCCCEEEECCCCEEEEECCHHH
AIDKVLEHVVARDYRVENRMTLDVVVRHQGTVSDHGWALNEVSLEKGPRLGVLGVVVEID
HHHHHHHHHHHCCEECCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEEEEEEC
GRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPAA
CEEEEEECCCEEEEECCCCCEEEEEECCCCEECCCCEEEEEECCCCCEEECCCEECCCCE
TIAIEIEADGHDALVFCDGRREMLIPAGSRIEVKRCDTAVKWARLDSAPFTDRLVRKFRL
EEEEEEEECCCEEEEEECCCCEEEECCCCEEEEECCCCHHEEEECCCCCHHHHHHHHHCC
PVTGWRGN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA