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The map label for this gene is tesB1

Identifier: 41407409

GI number: 41407409

Start: 1398947

End: 1399849

Strand: Direct

Name: tesB1

Synonym: MAP1311

Alternate gene names: 41407409

Gene position: 1398947-1399849 (Clockwise)

Preceding gene: 41407408

Following gene: 41407410

Centisome position: 28.97

GC content: 67.0

Gene sequence:

>903_bases
GTGCCAGCCGGCGCTGAATCCCAGGAGCCGAACACCACGGCCGACTTCGAGGAGCTGCTGGCGACGCTGGACCTCCGGCG
CGTCGCCGACGATCTGTTCGTCGGATCGCATCCCAGCAAGAGTCCGATGCGAACGTTCGGCGGACAGCTCATGTCGCAGT
CGTTTGTGGCCAGCAGCCGCAGCCTGATTCGCGACGACCTGCCCCCCAGCGCGCTCTCGGTGCATTTCATCAACGGCGGC
GACACCGGCAAGGACATCGAATACCGCGTCACCCGGTTGCGCGACGAGCGGCGGTTCGCCAACCGCCGCGTCGACGCGGT
GCAGGACGGCACGCTGCTGTCCTCGGCGCTGATCTCCTACATGGCCGGTGGCCGCGGACTCGAGCACGGCGTCGACCCGC
CACGGGTGGCCGACCCGGAGACCCAGCCCACGATCGGCGAGCTACTGCGCGGCTACGAAGAGACCGTGCCGCACTTCGTC
AACGCGCTGCAGCCGATCGAATGGCGCTACACCAACGACCCGGCGTGGGTGATGCGGACGAAAGGGGAGCGGCTGCCCCA
CAATCGGGTCTGGGTCAAGGCGCTGGGCAAGCTTCCCGACGACCCGGTCCTGCACACCGCGACCATGGTGTACTCCTCGG
ACACCACGGTGCTGGACTCCGTCATCACCACGCACGGTCTTTCCTGGGGATTCGACCGCATTTTCGCCGCCTCGGCCAAC
CATTCCATCTGGTTTCACCGTCAGGTCGACTTCAACGACTGGGTGCTGTACTCCACGTCGTCGCCGGTGGCCGCGGATTC
GCGCGGGCTGGGCACCGGGCATTTCTTCGACCGGTCCGGGCAACCGCTGGCCACCGTCGTGCAGGAGGGTGTGCTGAAAT
ACTTTCCCTCCGCCCGCCGGTAA

Upstream 100 bases:

>100_bases
GCACCGGATCGGGGAGGACGACGTCTAGCCTGCCCGGCGACGACACGGGCCGCTGCGCGGCCTGAGGAACGGGCGGGCGC
ATCGAACCAGAGGAGAGCTC

Downstream 100 bases:

>100_bases
ACCGTTACGCAAAAGCTGCAGGATATCGGCCCGAAACCGGCCGATACGAGCGGGATCGGGCGTAATTTTGACGGTGCCGG
GTATTCGGTGCAGAGGCGGC

Product: TesB1

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MPAGAESQEPNTTADFEELLATLDLRRVADDLFVGSHPSKSPMRTFGGQLMSQSFVASSRSLIRDDLPPSALSVHFINGG
DTGKDIEYRVTRLRDERRFANRRVDAVQDGTLLSSALISYMAGGRGLEHGVDPPRVADPETQPTIGELLRGYEETVPHFV
NALQPIEWRYTNDPAWVMRTKGERLPHNRVWVKALGKLPDDPVLHTATMVYSSDTTVLDSVITTHGLSWGFDRIFAASAN
HSIWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFDRSGQPLATVVQEGVLKYFPSARR

Sequences:

>Translated_300_residues
MPAGAESQEPNTTADFEELLATLDLRRVADDLFVGSHPSKSPMRTFGGQLMSQSFVASSRSLIRDDLPPSALSVHFINGG
DTGKDIEYRVTRLRDERRFANRRVDAVQDGTLLSSALISYMAGGRGLEHGVDPPRVADPETQPTIGELLRGYEETVPHFV
NALQPIEWRYTNDPAWVMRTKGERLPHNRVWVKALGKLPDDPVLHTATMVYSSDTTVLDSVITTHGLSWGFDRIFAASAN
HSIWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFDRSGQPLATVVQEGVLKYFPSARR
>Mature_299_residues
PAGAESQEPNTTADFEELLATLDLRRVADDLFVGSHPSKSPMRTFGGQLMSQSFVASSRSLIRDDLPPSALSVHFINGGD
TGKDIEYRVTRLRDERRFANRRVDAVQDGTLLSSALISYMAGGRGLEHGVDPPRVADPETQPTIGELLRGYEETVPHFVN
ALQPIEWRYTNDPAWVMRTKGERLPHNRVWVKALGKLPDDPVLHTATMVYSSDTTVLDSVITTHGLSWGFDRIFAASANH
SIWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFDRSGQPLATVVQEGVLKYFPSARR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=298, Percent_Identity=30.2013422818792, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1786657, Length=271, Percent_Identity=30.9963099630996, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=28.8659793814433, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17558508, Length=300, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17531889, Length=269, Percent_Identity=27.1375464684015, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17531885, Length=269, Percent_Identity=27.5092936802974, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115532456, Length=269, Percent_Identity=27.1375464684015, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33324; Mature: 33192

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAGAESQEPNTTADFEELLATLDLRRVADDLFVGSHPSKSPMRTFGGQLMSQSFVASSR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
SLIRDDLPPSALSVHFINGGDTGKDIEYRVTRLRDERRFANRRVDAVQDGTLLSSALISY
HHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MAGGRGLEHGVDPPRVADPETQPTIGELLRGYEETVPHFVNALQPIEWRYTNDPAWVMRT
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEC
KGERLPHNRVWVKALGKLPDDPVLHTATMVYSSDTTVLDSVITTHGLSWGFDRIFAASAN
CCCCCCCHHHHHHHHHCCCCCCHHEEEEEEECCCHHHHHHHHHHCCCCCCHHHHEEECCC
HSIWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFDRSGQPLATVVQEGVLKYFPSARR
CCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PAGAESQEPNTTADFEELLATLDLRRVADDLFVGSHPSKSPMRTFGGQLMSQSFVASSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
SLIRDDLPPSALSVHFINGGDTGKDIEYRVTRLRDERRFANRRVDAVQDGTLLSSALISY
HHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MAGGRGLEHGVDPPRVADPETQPTIGELLRGYEETVPHFVNALQPIEWRYTNDPAWVMRT
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEC
KGERLPHNRVWVKALGKLPDDPVLHTATMVYSSDTTVLDSVITTHGLSWGFDRIFAASAN
CCCCCCCHHHHHHHHHCCCCCCHHEEEEEEECCCHHHHHHHHHHCCCCCCHHHHEEECCC
HSIWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFDRSGQPLATVVQEGVLKYFPSARR
CCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]