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The map label for this gene is hisS

Identifier: 41407150

GI number: 41407150

Start: 1102635

End: 1103897

Strand: Direct

Name: hisS

Synonym: MAP1052

Alternate gene names: 41407150

Gene position: 1102635-1103897 (Clockwise)

Preceding gene: 41407149

Following gene: 41407151

Centisome position: 22.83

GC content: 70.47

Gene sequence:

>1263_bases
GTGCCGGAATTCAGCGCTCCCAAGGGTGTGCCCGACTACGTGCCGCCGGACTCGGCGCAGTTCGTCGCGGTCCGCTCCGG
CCTGCTGGACGCCGCCCGCCGCGCCGGGTACGGCGACATCGAGTTGCCCATCTTCGAGGACACCGCGCTGTTCGCCCGCG
GCGTCGGCGAATCCACCGACGTGGTGTCCAAGGAGATGTACACCTTCGCCGACCGCGGCGACCGCTCGGTGACGCTGCGG
CCCGAGGGTACGGCCGGCGTGGTGCGCGCGGTGATCGAGCACGGCCTGGACCGGGGCACGCTGCCGGTCAAATTGTGTTA
TGCGGGACCGTTTTTCCGCTACGAGCGCCCCCAGGCGGGTCGCTACCGCCAGCTGCAGCAGGTCGGTGTGGAGGCGATCG
GGGTGGACGACCCGGCGCTGGACGCCGAGGTGATCGCCGTCGCCGACGCCGGGTTCCGCTCGCTGGGGCTGGACGGGTTC
CGCTTGGAGATCACCTCGCTGGGCGACGACAGCTGCCGTCCGCAATACCGGGAACTGTTGCAGGACTTCCTGTTCGGTCT
CGACCTCGACGAAGAAACCCGGCGGCGCGCGCGGCTGAATCCATTGCGCGTCCTCGACGACAAACGGCCCGAGGTGCGGG
CGATGACGGCCGACGCGCCGGTGCTGCTCGATCACCTCTCCGATGCGGCCAAGCAGCACTTCGACACCGTGCTGGCGCAC
CTGGACGCGCTCGGGGTGCCCTACGTGATCAACCCGCGCATGGTGCGCGGGCTCGACTACTACACCAAGACCACGTTCGA
GTTCGTGCACGACGGTCTCGGCGCCCAGTCCGGCATCGGCGGCGGTGGCCGCTACGACGGGCTGATGCGTCAGCTCGGCG
GACAAGACTTGTCCGGCATCGGATTTGGGCTCGGCGTGGACCGTACCCTGCTGGCGCTGCGCGCCGAGGGCAAGAGCGTG
GGCTCGGCGGCGCGCTGCGACGTCTTCGGCGTCCCGCTGAGCGATCAGGCCAAGCTGCGGCTGGCCGTGCTGGCCGCCGG
GCTGCGCGCCGCCGGCGTGCGCGTCGACATGGCCTACGGCGCGCGGGGGCTCAAGGGCGCGATGCGCGCGGCCGACCGCT
CCGGTGCCCGCATCGCCCTGGTTCTCGGCGACCGCGACATCGACGCCGGCACGGTGGGCGTGAAGGATCTGCAGACCGGC
TCGCAGGTGTCGGTGGAACTGGATTCCGTTGTCGCCGAAGTTCTTTCACAACTGGGCCGCTAG

Upstream 100 bases:

>100_bases
GGTGCTCGACGACGACACCGTGGTGCTGCCCGGGCACGGCAACGCCACCACCATCGGCGCCGAACGGCGCCTCAACCCGT
TCCTCGAAGGCCTGTAGCCC

Downstream 100 bases:

>100_bases
CCTTAGCTGCGGCCGTCGCGTTATTTCTTGCTGGGGATGACGATGACGACGATCAGGGTCAGGATCGAGAAGAACAGTCC
CAGGATTCCCCAGCCCAGCG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MPEFSAPKGVPDYVPPDSAQFVAVRSGLLDAARRAGYGDIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLR
PEGTAGVVRAVIEHGLDRGTLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGF
RLEITSLGDDSCRPQYRELLQDFLFGLDLDEETRRRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAH
LDALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGGQDLSGIGFGLGVDRTLLALRAEGKSV
GSAARCDVFGVPLSDQAKLRLAVLAAGLRAAGVRVDMAYGARGLKGAMRAADRSGARIALVLGDRDIDAGTVGVKDLQTG
SQVSVELDSVVAEVLSQLGR

Sequences:

>Translated_420_residues
MPEFSAPKGVPDYVPPDSAQFVAVRSGLLDAARRAGYGDIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLR
PEGTAGVVRAVIEHGLDRGTLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGF
RLEITSLGDDSCRPQYRELLQDFLFGLDLDEETRRRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAH
LDALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGGQDLSGIGFGLGVDRTLLALRAEGKSV
GSAARCDVFGVPLSDQAKLRLAVLAAGLRAAGVRVDMAYGARGLKGAMRAADRSGARIALVLGDRDIDAGTVGVKDLQTG
SQVSVELDSVVAEVLSQLGR
>Mature_419_residues
PEFSAPKGVPDYVPPDSAQFVAVRSGLLDAARRAGYGDIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRP
EGTAGVVRAVIEHGLDRGTLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGFR
LEITSLGDDSCRPQYRELLQDFLFGLDLDEETRRRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAHL
DALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGGQDLSGIGFGLGVDRTLLALRAEGKSVG
SAARCDVFGVPLSDQAKLRLAVLAAGLRAAGVRVDMAYGARGLKGAMRAADRSGARIALVLGDRDIDAGTVGVKDLQTGS
QVSVELDSVVAEVLSQLGR

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=422, Percent_Identity=43.1279620853081, Blast_Score=334, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI71993686, Length=457, Percent_Identity=23.1947483588621, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993693, Length=457, Percent_Identity=23.1947483588621, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_MYCPA (P60917)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_959986.1
- ProteinModelPortal:   P60917
- SMR:   P60917
- EnsemblBacteria:   EBMYCT00000036668
- GeneID:   2718492
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1052
- NMPDR:   fig|262316.1.peg.1052
- GeneTree:   EBGT00050000017632
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BRENDA:   6.1.1.21
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 45037; Mature: 44905

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50862 AA_TRNA_LIGASE_II; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFSAPKGVPDYVPPDSAQFVAVRSGLLDAARRAGYGDIELPIFEDTALFARGVGESTD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCHH
VVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGTLPVKLCYAGPFFRYERPQAG
HHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCH
RYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGFRLEITSLGDDSCRPQYRELL
HHHHHHHCCCEEECCCCCCCCCEEEEEECCCHHHCCCCCEEEEEEECCCCCCCHHHHHHH
QDFLFGLDLDEETRRRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAH
HHHHHCCCCCHHHHHHHCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LDALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGGQDLSGI
HHHCCCCEEECCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
GFGLGVDRTLLALRAEGKSVGSAARCDVFGVPLSDQAKLRLAVLAAGLRAAGVRVDMAYG
EECCCCCHHHEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEHHHC
ARGLKGAMRAADRSGARIALVLGDRDIDAGTVGVKDLQTGSQVSVELDSVVAEVLSQLGR
CCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEFSAPKGVPDYVPPDSAQFVAVRSGLLDAARRAGYGDIELPIFEDTALFARGVGESTD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCHH
VVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGTLPVKLCYAGPFFRYERPQAG
HHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCH
RYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGFRLEITSLGDDSCRPQYRELL
HHHHHHHCCCEEECCCCCCCCCEEEEEECCCHHHCCCCCEEEEEEECCCCCCCHHHHHHH
QDFLFGLDLDEETRRRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAH
HHHHHCCCCCHHHHHHHCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LDALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGGQDLSGI
HHHCCCCEEECCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
GFGLGVDRTLLALRAEGKSVGSAARCDVFGVPLSDQAKLRLAVLAAGLRAAGVRVDMAYG
EECCCCCHHHEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEHHHC
ARGLKGAMRAADRSGARIALVLGDRDIDAGTVGVKDLQTGSQVSVELDSVVAEVLSQLGR
CCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA