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The map label for this gene is cysM2

Identifier: 41407122

GI number: 41407122

Start: 1069499

End: 1070905

Strand: Direct

Name: cysM2

Synonym: MAP1024

Alternate gene names: 41407122

Gene position: 1069499-1070905 (Clockwise)

Preceding gene: 41407121

Following gene: 41407123

Centisome position: 22.14

GC content: 71.36

Gene sequence:

>1407_bases
ATGCGGATCGCGCAGCACATCAGTGACCTCATCGGCGGCACGCCGCTGGTGCGGCTGAACTCCGTCGTGCCCGACGGCGC
GGGCATCGTGGCGGCCAAGGTCGAATACCTCAACCCCGGCGGCAGCTCCAAGGACCGGATCGCGGTCAGGATGATCGACG
CCGCCGAGGCCAGCGGGGCGCTGAAGCCCGGCGGCACCATCGTCGAACCCACCTCGGGCAACACCGGCGTGGGGCTGGCG
CTGGTGGCCCAGCAGCGCGGCTACAAGTGCGTGTTCGTCTGCCCGGACAAGGTCGGCGAGGACAAGCGCAACGTGTTGAT
GGCGTACGGCGCCGAGGTGGTGGTGTGCCCGACGGCGGTGCCGCCCGAGCATCCGGACAGCTACTACAGCGTCTCGGACC
GGCTGGTCACCGAGATCGAAGGCGCCTGGAAGCCCGACCAGTACGCCAACCCGGAGGGCCCGGCCAGCCACTACGCCACC
ACCGGCCCGGAGATCTGGGCCGACACCGACGGCAAGGTCACCCATTTCGTCGCCGGCATCGGCACCGGCGGCACCATCAC
CGGCGCGGGCCGCTACCTCAAGGAGGTGTCCGGCGGCCGGGTCCGCGTCATCGGCGCCGACCCCGAGGGATCGGTGTATT
CCGGCGGCACCGGCCGGCCCTATCTGGTCGAGGGCGTCGGCGAGGACTTCTGGCCGCAGGCCTACGACCGCACGGTGCCC
GACGAGATCATCGCGGTCTCCGACTCCGACTCGTTCAACATGACCCGGCGGCTGGCCCGCGAGGAGGCGATGCTGGTCGG
CGGGTCCTGCGGCATGGCCGTGGTGGCGGCGCTGCGGGTGGCCGAGCAGGCCGGGCCCGACGCGCTGGTGGTGGTGCTGC
TGCCCGACGGCGGGCGCGGCTACATGGCGAAGATCTTCAACGACGCCTGGATGTCCTCCTACGGGTTCCTGCGTACCCGG
CTGGACGGGTCGACCGACCAGTCCCGCGTCGGCGACGTGTTGCGCCGCAAGTCCGGTGAGCTGCCCGACCTGGTGCACAC
CCACCCGTCGGAAACCGTGCGCGACGCCATCGGCATCCTGCGCGAGTACGGGGTGTCCCAGATGCCGGTGGTCGGCGCCG
AGCCGCCGGTGATGGCCGGCGAGGTCGCCGGCAGCGTCTCCGAACGTGAGCTGCTGTCAGCGGTTTTCGAGGGCCGGGCG
AAGCTGGCCGACGCGGTCTCGCTGCACATGAGCCCGCCGCTGCCGATGATCGGCGCCGGCGAATCGGTCAGCGCGGCGGG
CAAGGCGCTGCGCGATTGGGACGCCCTGATGGTGGTCGAGGAGGGCAAGCCGGTGGGTGTGATCACCCGCTACGACTTGC
TCGGTTTCCTCTCCGAGGGACCCCGCGGATCGGGCGGGCGGCGCTAG

Upstream 100 bases:

>100_bases
CGAGGCCAGGCGGTCGCTGCGCCAGATCGGCGACTACATCCGCGAGGCCACCGGCTGAGTCCTTGTGCGCCGCGGGAAAC
CGCCTGAGACGATGTGACGC

Downstream 100 bases:

>100_bases
GTCGCGCGTCTCGCTCGGACGTCGAACCCTCGGGTACTGTTTCGGCCTAGTTCGACTGATGTCCAGCTGACCCGGAGTGG
AAGGTTGCCCATGACCGATC

Product: CysM2

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLA
LVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEGPASHYAT
TGPEIWADTDGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVP
DEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTR
LDGSTDQSRVGDVLRRKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRA
KLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR

Sequences:

>Translated_468_residues
MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLA
LVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEGPASHYAT
TGPEIWADTDGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVP
DEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTR
LDGSTDQSRVGDVLRRKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRA
KLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR
>Mature_468_residues
MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLA
LVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEGPASHYAT
TGPEIWADTDGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVP
DEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTR
LDGSTDQSRVGDVLRRKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRA
KLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=483, Percent_Identity=39.3374741200828, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI295821200, Length=483, Percent_Identity=39.3374741200828, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI4557415, Length=483, Percent_Identity=39.3374741200828, Blast_Score=291, Evalue=9e-79,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=38.1877022653722, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=38.5579937304075, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=44.3768996960486, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=41.7177914110429, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17562970, Length=284, Percent_Identity=43.6619718309859, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI32566674, Length=284, Percent_Identity=43.6619718309859, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=39.9328859060403, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=331, Percent_Identity=39.8791540785499, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=329, Percent_Identity=39.5136778115502, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566672, Length=218, Percent_Identity=37.6146788990826, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321594, Length=505, Percent_Identity=33.0693069306931, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=33.1325301204819, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24643623, Length=487, Percent_Identity=35.523613963039, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI20129101, Length=487, Percent_Identity=35.523613963039, Blast_Score=244, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49193; Mature: 49193

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVRMIDAAEASGA
CCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCC
LKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAV
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHCEEEEECCEEEEECCCC
PPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEGPASHYATTGPEIWADTDGKVTHFVAGI
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVP
CCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCHHHCCCCC
DEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPDGGRG
CCEEEECCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
YMAKIFNDAWMSSYGFLRTRLDGSTDQSRVGDVLRRKSGELPDLVHTHPSETVRDAIGIL
HHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHH
REYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSLHMSPPLPMIGAG
HHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECC
ESVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR
CCHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVRMIDAAEASGA
CCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCC
LKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAV
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHCEEEEECCEEEEECCCC
PPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEGPASHYATTGPEIWADTDGKVTHFVAGI
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVP
CCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCHHHCCCCC
DEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPDGGRG
CCEEEECCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
YMAKIFNDAWMSSYGFLRTRLDGSTDQSRVGDVLRRKSGELPDLVHTHPSETVRDAIGIL
HHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHH
REYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSLHMSPPLPMIGAG
HHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECC
ESVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR
CCHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]