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The map label for this gene is lipU

Identifier: 41407121

GI number: 41407121

Start: 1068383

End: 1069456

Strand: Direct

Name: lipU

Synonym: MAP1023

Alternate gene names: 41407121

Gene position: 1068383-1069456 (Clockwise)

Preceding gene: 41407117

Following gene: 41407122

Centisome position: 22.12

GC content: 72.07

Gene sequence:

>1074_bases
GTGTTGAGCATGACCGCACCGAGCGAGGTATCGGGACCGCAGAGTCCCGTCCGTGTCCACGACGTCCTCAAGGCGCGCCG
CGCGCGCATCCGCAAGTTCGCGATCAGCGACGGCGCACCGGTCGAGGTTCTCGAATCCGGACCCAGCGTTGCTGCGCGAC
TGGCCAACCTAACCTCACGGCTGACCATCCGGCCGATTCTGGCCGTCGGCAGCCACGCCCCCAACCTGCCCTGGCCGTGG
GGTCTGATCGACCTCACCGCCCGGGTGCTGCTGCCGGTGTCGGCCACCGTGCGCGAGACGGTGGCGCTGCCGCACGCGTC
GGCGCAGCTGGTCCGCGCGCCCGGGGTGCTGCCCGCCGACGGCACCCGCCGCGTCGTGGTCTACCTGCACGGCGGGGCGT
TTCTGACCTGCGGGGCGAACTCGCACGGCCGGCTCGTCGAAGCCCTTTCCACCTTCGCCGACGCGCCCGTGCTGGTGGTG
AATTACCGTCTGCTGCCGAAGAATTCGGTCGGCATGGCGCTGCAGGACTGCCACGACGCGTACCAGTGGCTGCGGCTGCG
CGGCTACCAGCCCGACCAGATCGTGCTGGCCGGCGACTCCGCGGGCGGCTACCTGGCGCTGACGCTGGCGCAACGCCTGC
AGCGCGAGGGTGAGGAACCCGCCGCGCTGGTGATGATCTCGCCGCTGCTGCAGCTGGCCAAGGAGCCCAAGCAGGCCCAC
CCCAACATCGACACCGACGCGATGTTCGGCGCCGGCGCGTTCGACGCCCTGGCCGAGCTGGTGGCCGGCGCGGCGGCGAA
GAACATCGTCGACGGCAAGCCCGAGGAGATCTACGAGCCGCTCGAGCACATCGAGCCGGGGCTGCCGCGCACGCTGACTC
ACGTGTCGGGCTCCGAGGTGCTGCTGCACGACGCCCGGCTGGCGGCGAGCCGGCTGGCCGCGGCGGGCGTGCCGGCCGAG
GTGCGGGTGTGGCCGGGACAGATCCACGACTTCCAGCTGGCCGCGCCGATGGTGCCCGAGGCCAGGCGGTCGCTGCGCCA
GATCGGCGACTACATCCGCGAGGCCACCGGCTGA

Upstream 100 bases:

>100_bases
AAGCTGAGAGCGAGGGGATGGCTGAGCGCCTTGGCACACGGCTGAACCAGACGCTCAACAGCCTCGTCACATGCTGTATC
GCACTACAACGGCGTAGGAA

Downstream 100 bases:

>100_bases
GTCCTTGTGCGCCGCGGGAAACCGCCTGAGACGATGTGACGCATGCGGATCGCGCAGCACATCAGTGACCTCATCGGCGG
CACGCCGCTGGTGCGGCTGA

Product: LipU

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLSMTAPSEVSGPQSPVRVHDVLKARRARIRKFAISDGAPVEVLESGPSVAARLANLTSRLTIRPILAVGSHAPNLPWPW
GLIDLTARVLLPVSATVRETVALPHASAQLVRAPGVLPADGTRRVVVYLHGGAFLTCGANSHGRLVEALSTFADAPVLVV
NYRLLPKNSVGMALQDCHDAYQWLRLRGYQPDQIVLAGDSAGGYLALTLAQRLQREGEEPAALVMISPLLQLAKEPKQAH
PNIDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLTHVSGSEVLLHDARLAASRLAAAGVPAE
VRVWPGQIHDFQLAAPMVPEARRSLRQIGDYIREATG

Sequences:

>Translated_357_residues
MLSMTAPSEVSGPQSPVRVHDVLKARRARIRKFAISDGAPVEVLESGPSVAARLANLTSRLTIRPILAVGSHAPNLPWPW
GLIDLTARVLLPVSATVRETVALPHASAQLVRAPGVLPADGTRRVVVYLHGGAFLTCGANSHGRLVEALSTFADAPVLVV
NYRLLPKNSVGMALQDCHDAYQWLRLRGYQPDQIVLAGDSAGGYLALTLAQRLQREGEEPAALVMISPLLQLAKEPKQAH
PNIDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLTHVSGSEVLLHDARLAASRLAAAGVPAE
VRVWPGQIHDFQLAAPMVPEARRSLRQIGDYIREATG
>Mature_357_residues
MLSMTAPSEVSGPQSPVRVHDVLKARRARIRKFAISDGAPVEVLESGPSVAARLANLTSRLTIRPILAVGSHAPNLPWPW
GLIDLTARVLLPVSATVRETVALPHASAQLVRAPGVLPADGTRRVVVYLHGGAFLTCGANSHGRLVEALSTFADAPVLVV
NYRLLPKNSVGMALQDCHDAYQWLRLRGYQPDQIVLAGDSAGGYLALTLAQRLQREGEEPAALVMISPLLQLAKEPKQAH
PNIDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLTHVSGSEVLLHDARLAASRLAAAGVPAE
VRVWPGQIHDFQLAAPMVPEARRSLRQIGDYIREATG

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Secreted (Potential). Note=External to the cytoplasmic membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=95, Percent_Identity=35.7894736842105, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI72001146, Length=171, Percent_Identity=29.8245614035088, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 38125; Mature: 38125

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS01174 LIPASE_GDXG_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSMTAPSEVSGPQSPVRVHDVLKARRARIRKFAISDGAPVEVLESGPSVAARLANLTSR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHH
LTIRPILAVGSHAPNLPWPWGLIDLTARVLLPVSATVRETVALPHASAQLVRAPGVLPAD
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHCCCCCCCC
GTRRVVVYLHGGAFLTCGANSHGRLVEALSTFADAPVLVVNYRLLPKNSVGMALQDCHDA
CCCEEEEEEECCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHH
YQWLRLRGYQPDQIVLAGDSAGGYLALTLAQRLQREGEEPAALVMISPLLQLAKEPKQAH
HHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHCC
PNIDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLTHVSGSEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCEE
LLHDARLAASRLAAAGVPAEVRVWPGQIHDFQLAAPMVPEARRSLRQIGDYIREATG
EEHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSMTAPSEVSGPQSPVRVHDVLKARRARIRKFAISDGAPVEVLESGPSVAARLANLTSR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHH
LTIRPILAVGSHAPNLPWPWGLIDLTARVLLPVSATVRETVALPHASAQLVRAPGVLPAD
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHCCCCCCCC
GTRRVVVYLHGGAFLTCGANSHGRLVEALSTFADAPVLVVNYRLLPKNSVGMALQDCHDA
CCCEEEEEEECCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHH
YQWLRLRGYQPDQIVLAGDSAGGYLALTLAQRLQREGEEPAALVMISPLLQLAKEPKQAH
HHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHCC
PNIDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLTHVSGSEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCEE
LLHDARLAASRLAAAGVPAEVRVWPGQIHDFQLAAPMVPEARRSLRQIGDYIREATG
EEHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2545531 [H]