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The map label for this gene is mazG [H]

Identifier: 41407086

GI number: 41407086

Start: 1029145

End: 1030146

Strand: Direct

Name: mazG [H]

Synonym: MAP0988

Alternate gene names: 41407086

Gene position: 1029145-1030146 (Clockwise)

Preceding gene: 41407085

Following gene: 41407087

Centisome position: 21.31

GC content: 70.86

Gene sequence:

>1002_bases
GTGATTGTGATCTTGTGCGACCCGCGCCGGCCGTCGCTGGTGCCGGTCGAGGCCGTCGAGCATCTCACCGGCGAGGTGCA
GTACACCGAGGAGATGCCGATCGCGGTGCCCTGGTCGCTGCCGGCGGTGCGCCCGGTGCACTCCGGCGACCCCGATGATC
CGGCGCCGGTGCTGCTGTCGTCGGACCGCGACCACCCCGCCGTCACCGCCCGGCTGGCCGCCGGGGCGCGGCTGATCTCG
GCGCCGGACGCCCCGCGCGGCGAACGGCTGGTCGACGCGGTGGCGATGATGGACAAGCTGCGCGCCGGACCGTGGGAAAG
TGAGCAAACCCACGAGTCGCTGCGCCGGTTTCTGCTGGAGGAGACCTACGAGTTGCTGGACGCGGTGGCCGGCGGCAACG
CCGAGGCGTTGCGTGACGAACTCGGCGACGTGCTGCTGCAGGTCCTCTTCCACGCCCGCATCGCCGAGGACGCCCCGCAG
TCGGCCTTCACCATCGACGACGTCGCCGCCGCGCTGATCCGCAAACTGGGCAACCGGGTGCCGGGAGTGCTTGCCGGGCA
AACCATTTCGCTCGAAGAGCAGCTGGCGCAGTGGGAAGAGCGCAAGGCGGCCGAGAAGCCGCGGAAATCGGTGATGGACG
ACGTGCACACCGGGCAACCGGCGCTGGCGCTGGCGCAGAAGGTGATCGGGCGGGCCGAGAAGGCCGGTCTGCCCGCCGAC
CTGATCCCGCCGCAGGTCACCTCGATCGCAATATCGGCCGACGTGGACGCTGAAAGTGCTTTGCGCACAGCGGTTTTGGA
TTTCGTGGCAACCGTCCGCGGTGTCGAGCGCTCGATCGCGGCGGCGCGCCGCGGCACCAGTGTCCCCGACGAGTTCGACA
TCGCCCCGCTCGGTGAGATCTCCGAGCAGGAGTGGCGGCAGCACTGGCCGGCGGGCGACACCGATCCCGAGCCGGCCCCC
GCCGAGCAGCTCACCGACGACGCCGGCGGCGACGAGAACTGA

Upstream 100 bases:

>100_bases
AGATGGTGGCCAACCTGGTGACGGCGCTGCAGGGTAAACCGCAGACGGATGTCGGCACCGGCACGCCGGTGGCGGCGATG
GCCAGTGAGGAGGGGCGCGG

Downstream 100 bases:

>100_bases
GCGGCCGGTCCCGTTGGCCGTCGGCCCGTGGCGTGTTCACCGCCGCCGAGAGCGATCACCGCATTGTTTGCCGGATTTGG
CGTCCGCGCCTCGGTAATAT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIVILCDPRRPSLVPVEAVEHLTGEVQYTEEMPIAVPWSLPAVRPVHSGDPDDPAPVLLSSDRDHPAVTARLAAGARLIS
APDAPRGERLVDAVAMMDKLRAGPWESEQTHESLRRFLLEETYELLDAVAGGNAEALRDELGDVLLQVLFHARIAEDAPQ
SAFTIDDVAAALIRKLGNRVPGVLAGQTISLEEQLAQWEERKAAEKPRKSVMDDVHTGQPALALAQKVIGRAEKAGLPAD
LIPPQVTSIAISADVDAESALRTAVLDFVATVRGVERSIAAARRGTSVPDEFDIAPLGEISEQEWRQHWPAGDTDPEPAP
AEQLTDDAGGDEN

Sequences:

>Translated_333_residues
MIVILCDPRRPSLVPVEAVEHLTGEVQYTEEMPIAVPWSLPAVRPVHSGDPDDPAPVLLSSDRDHPAVTARLAAGARLIS
APDAPRGERLVDAVAMMDKLRAGPWESEQTHESLRRFLLEETYELLDAVAGGNAEALRDELGDVLLQVLFHARIAEDAPQ
SAFTIDDVAAALIRKLGNRVPGVLAGQTISLEEQLAQWEERKAAEKPRKSVMDDVHTGQPALALAQKVIGRAEKAGLPAD
LIPPQVTSIAISADVDAESALRTAVLDFVATVRGVERSIAAARRGTSVPDEFDIAPLGEISEQEWRQHWPAGDTDPEPAP
AEQLTDDAGGDEN
>Mature_333_residues
MIVILCDPRRPSLVPVEAVEHLTGEVQYTEEMPIAVPWSLPAVRPVHSGDPDDPAPVLLSSDRDHPAVTARLAAGARLIS
APDAPRGERLVDAVAMMDKLRAGPWESEQTHESLRRFLLEETYELLDAVAGGNAEALRDELGDVLLQVLFHARIAEDAPQ
SAFTIDDVAAALIRKLGNRVPGVLAGQTISLEEQLAQWEERKAAEKPRKSVMDDVHTGQPALALAQKVIGRAEKAGLPAD
LIPPQVTSIAISADVDAESALRTAVLDFVATVRGVERSIAAARRGTSVPDEFDIAPLGEISEQEWRQHWPAGDTDPEPAP
AEQLTDDAGGDEN

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=182, Percent_Identity=36.8131868131868, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 35830; Mature: 35830

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVILCDPRRPSLVPVEAVEHLTGEVQYTEEMPIAVPWSLPAVRPVHSGDPDDPAPVLLS
CEEEEECCCCCCCCHHHHHHHHHCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEEE
SDRDHPAVTARLAAGARLISAPDAPRGERLVDAVAMMDKLRAGPWESEQTHESLRRFLLE
CCCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ETYELLDAVAGGNAEALRDELGDVLLQVLFHARIAEDAPQSAFTIDDVAAALIRKLGNRV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PGVLAGQTISLEEQLAQWEERKAAEKPRKSVMDDVHTGQPALALAQKVIGRAEKAGLPAD
CCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
LIPPQVTSIAISADVDAESALRTAVLDFVATVRGVERSIAAARRGTSVPDEFDIAPLGEI
CCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SEQEWRQHWPAGDTDPEPAPAEQLTDDAGGDEN
CHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MIVILCDPRRPSLVPVEAVEHLTGEVQYTEEMPIAVPWSLPAVRPVHSGDPDDPAPVLLS
CEEEEECCCCCCCCHHHHHHHHHCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEEE
SDRDHPAVTARLAAGARLISAPDAPRGERLVDAVAMMDKLRAGPWESEQTHESLRRFLLE
CCCCCHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ETYELLDAVAGGNAEALRDELGDVLLQVLFHARIAEDAPQSAFTIDDVAAALIRKLGNRV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PGVLAGQTISLEEQLAQWEERKAAEKPRKSVMDDVHTGQPALALAQKVIGRAEKAGLPAD
CCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
LIPPQVTSIAISADVDAESALRTAVLDFVATVRGVERSIAAARRGTSVPDEFDIAPLGEI
CCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SEQEWRQHWPAGDTDPEPAPAEQLTDDAGGDEN
CHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]