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The map label for this gene is cprA

Identifier: 41407067

GI number: 41407067

Start: 1005043

End: 1005738

Strand: Direct

Name: cprA

Synonym: MAP0969

Alternate gene names: 41407067

Gene position: 1005043-1005738 (Clockwise)

Preceding gene: 41407066

Following gene: 41407068

Centisome position: 20.81

GC content: 64.66

Gene sequence:

>696_bases
ATGGCCCGCCAAGTTCGGTCTGAGGCCACCCGGCAGAAGATCCTGGACTCGGCGATCGAAGTCTTCGGCGAGGTCGGTTA
CGCCGCGGCCGGGTGGAGCACCATCATCGAACGGACCGGCATGACCAAGGGTGCCCTGTATCACCACTTCGATTCCAAAG
AATCGTTGGCGTCCAACATCATCGAGGAGGGCTCCGACCGGCTGCTCAGTGCGTTCCGCAACGTGTGCGGGTCGTCGTCG
CCGGGGCTGGAAAACCTGGTGCACGGCACCTTCACCATCGTCGAGGTCTTGCGGTCGGACAAAATGGTGCGCGCCGCAGC
GCAATTGGCCACCGCGCTAAGCGGATTCAACGGTGCGGCCTCGCGCTTCTACGCGAATTTGGTGCTGGAAACGGCGCAGG
AGGCGCGGCGGGCGATCAAGGAAGGCGACCTGCGCGACGACATCGACCCCGACGTGCTGAGCGCGTCGCTGATGGGCACC
ATATTCGGGGCCCGGTTGATAGCGAGCACCATTTCCGGTCACGGCCGAATCGGTGACATCATCGGCGACCCCACCGCGCG
GTTGCACCAGATCTGGAGCCTGCTGCTGCCCGGCATCGTCTCGCAGGCATCGCTGCCGTATTTCGAGCAATTCCTGCGCC
GCGAGGGAATGCGCCACGCCACGGCCAACCCTGCCGCGCAACCGGAAGGCGAATAG

Upstream 100 bases:

>100_bases
CCCTCGCGATCAACACCAGTTCAACCGATGATGACGAGTCCTAGCGACCGGGCCGACGCGCGGTCCGCGCATCCGACGAG
CCTGCGGGGGTGCGGGGGCG

Downstream 100 bases:

>100_bases
CCTTCGGCGAGAGCCGTTGCCCGGGTGCCGCTTCGGTCGTCACGATCGCATTTCCGTTATTGGGGTTGAAGCGCTTTCAA
CAATGCATACTGTTCCGGTG

Product: CprA

Products: NA

Alternate protein names: A-factor-binding protein [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MARQVRSEATRQKILDSAIEVFGEVGYAAAGWSTIIERTGMTKGALYHHFDSKESLASNIIEEGSDRLLSAFRNVCGSSS
PGLENLVHGTFTIVEVLRSDKMVRAAAQLATALSGFNGAASRFYANLVLETAQEARRAIKEGDLRDDIDPDVLSASLMGT
IFGARLIASTISGHGRIGDIIGDPTARLHQIWSLLLPGIVSQASLPYFEQFLRREGMRHATANPAAQPEGE

Sequences:

>Translated_231_residues
MARQVRSEATRQKILDSAIEVFGEVGYAAAGWSTIIERTGMTKGALYHHFDSKESLASNIIEEGSDRLLSAFRNVCGSSS
PGLENLVHGTFTIVEVLRSDKMVRAAAQLATALSGFNGAASRFYANLVLETAQEARRAIKEGDLRDDIDPDVLSASLMGT
IFGARLIASTISGHGRIGDIIGDPTARLHQIWSLLLPGIVSQASLPYFEQFLRREGMRHATANPAAQPEGE
>Mature_230_residues
ARQVRSEATRQKILDSAIEVFGEVGYAAAGWSTIIERTGMTKGALYHHFDSKESLASNIIEEGSDRLLSAFRNVCGSSSP
GLENLVHGTFTIVEVLRSDKMVRAAAQLATALSGFNGAASRFYANLVLETAQEARRAIKEGDLRDDIDPDVLSASLMGTI
FGARLIASTISGHGRIGDIIGDPTARLHQIWSLLLPGIVSQASLPYFEQFLRREGMRHATANPAAQPEGE

Specific function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787904, Length=170, Percent_Identity=28.2352941176471, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24928; Mature: 24797

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQVRSEATRQKILDSAIEVFGEVGYAAAGWSTIIERTGMTKGALYHHFDSKESLASNI
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHH
IEEGSDRLLSAFRNVCGSSSPGLENLVHGTFTIVEVLRSDKMVRAAAQLATALSGFNGAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SRFYANLVLETAQEARRAIKEGDLRDDIDPDVLSASLMGTIFGARLIASTISGHGRIGDI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IGDPTARLHQIWSLLLPGIVSQASLPYFEQFLRREGMRHATANPAAQPEGE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARQVRSEATRQKILDSAIEVFGEVGYAAAGWSTIIERTGMTKGALYHHFDSKESLASNI
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHH
IEEGSDRLLSAFRNVCGSSSPGLENLVHGTFTIVEVLRSDKMVRAAAQLATALSGFNGAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SRFYANLVLETAQEARRAIKEGDLRDDIDPDVLSASLMGTIFGARLIASTISGHGRIGDI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IGDPTARLHQIWSLLLPGIVSQASLPYFEQFLRREGMRHATANPAAQPEGE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592371; 9813285; 2502536; 2111804; 9220006; 10540289; 9098075 [H]