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The map label for this gene is arpA [H]

Identifier: 41407066

GI number: 41407066

Start: 1004264

End: 1004986

Strand: Direct

Name: arpA [H]

Synonym: MAP0968

Alternate gene names: 41407066

Gene position: 1004264-1004986 (Clockwise)

Preceding gene: 41407065

Following gene: 41407067

Centisome position: 20.79

GC content: 65.56

Gene sequence:

>723_bases
GTGCCTCATCACCGCCCCCACGGGGGAGCCGAGCTTTCGAGCACGATGACCACCCATTCGACCGACGGACGAGCGGATGC
GACCCGGCAACAGATCCTGCGGGCCGCATCGCACCAGTTCGCCCGGCGGCCCTACCACGACGTCGGCCTCGACGACATCC
TCGCCGAGGCCGAGCTGACCAAGGGTGCGATGTACTTCCACTTCAAGTCGAAGCACGCGCTGGCGGTCGCGATCATCGAG
AGCCAGACCGCCAGCGGCGCCGTCGCCGTGCAGGACCTGCTGACCCGCGGGCTCTCCGGCCTGGAGACACTGATCGACTT
CTCCTATCTGATCGCCGTCAAGGACATCAAGACGGACCTGGTCCGGTCCGGGCTCAACCTGATGGAGTCGGTCGGGCTGT
CCGACGGGTTGCAGGAGAAGCTGTTCGACCGGTGGATCAAGGCCCTGGCCCGGGTCGCCGAGCAGGCCAAGGGCGAGGGC
GACATCAACGAGCACTGCGATCCGCAGGACATCGGCCGGTTGATGGTGTCGCTGCACATGGGGCTGCGCAAGACCAGCAA
CCTGGACGACCCGGAACGATTCCTGCGCGATCTGGAGAAGTGCTGGTCGCTGCTGCTCACCGGGATCCTGCAGCCGGACC
GCACCGAGTACTTCCAACAGTTCCTGCGCAGGCGTGCTGCCCTCGCGATCAACACCAGTTCAACCGATGATGACGAGTCC
TAG

Upstream 100 bases:

>100_bases
CCCCAAAAAGAACCGAGGTACTTGTGCCCTGCTCGAGCAACGGCGTCGTCAACGCGATGGCCGGCGCCACGGCCCGCGGC
GCCGGGCCCGGCAGGAACGC

Downstream 100 bases:

>100_bases
CGACCGGGCCGACGCGCGGTCCGCGCATCCGACGAGCCTGCGGGGGTGCGGGGGCGATGGCCCGCCAAGTTCGGTCTGAG
GCCACCCGGCAGAAGATCCT

Product: hypothetical protein

Products: NA

Alternate protein names: A-factor-binding protein [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MPHHRPHGGAELSSTMTTHSTDGRADATRQQILRAASHQFARRPYHDVGLDDILAEAELTKGAMYFHFKSKHALAVAIIE
SQTASGAVAVQDLLTRGLSGLETLIDFSYLIAVKDIKTDLVRSGLNLMESVGLSDGLQEKLFDRWIKALARVAEQAKGEG
DINEHCDPQDIGRLMVSLHMGLRKTSNLDDPERFLRDLEKCWSLLLTGILQPDRTEYFQQFLRRRAALAINTSSTDDDES

Sequences:

>Translated_240_residues
MPHHRPHGGAELSSTMTTHSTDGRADATRQQILRAASHQFARRPYHDVGLDDILAEAELTKGAMYFHFKSKHALAVAIIE
SQTASGAVAVQDLLTRGLSGLETLIDFSYLIAVKDIKTDLVRSGLNLMESVGLSDGLQEKLFDRWIKALARVAEQAKGEG
DINEHCDPQDIGRLMVSLHMGLRKTSNLDDPERFLRDLEKCWSLLLTGILQPDRTEYFQQFLRRRAALAINTSSTDDDES
>Mature_239_residues
PHHRPHGGAELSSTMTTHSTDGRADATRQQILRAASHQFARRPYHDVGLDDILAEAELTKGAMYFHFKSKHALAVAIIES
QTASGAVAVQDLLTRGLSGLETLIDFSYLIAVKDIKTDLVRSGLNLMESVGLSDGLQEKLFDRWIKALARVAEQAKGEGD
INEHCDPQDIGRLMVSLHMGLRKTSNLDDPERFLRDLEKCWSLLLTGILQPDRTEYFQQFLRRRAALAINTSSTDDDES

Specific function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26742; Mature: 26610

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHHRPHGGAELSSTMTTHSTDGRADATRQQILRAASHQFARRPYHDVGLDDILAEAELT
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KGAMYFHFKSKHALAVAIIESQTASGAVAVQDLLTRGLSGLETLIDFSYLIAVKDIKTDL
CCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSGLNLMESVGLSDGLQEKLFDRWIKALARVAEQAKGEGDINEHCDPQDIGRLMVSLHM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GLRKTSNLDDPERFLRDLEKCWSLLLTGILQPDRTEYFQQFLRRRAALAINTSSTDDDES
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCC
>Mature Secondary Structure 
PHHRPHGGAELSSTMTTHSTDGRADATRQQILRAASHQFARRPYHDVGLDDILAEAELT
CCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KGAMYFHFKSKHALAVAIIESQTASGAVAVQDLLTRGLSGLETLIDFSYLIAVKDIKTDL
CCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSGLNLMESVGLSDGLQEKLFDRWIKALARVAEQAKGEGDINEHCDPQDIGRLMVSLHM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GLRKTSNLDDPERFLRDLEKCWSLLLTGILQPDRTEYFQQFLRRRAALAINTSSTDDDES
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592371; 9813285; 2502536; 2111804; 9220006; 10540289; 9098075 [H]