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The map label for this gene is folK [H]

Identifier: 39998070

GI number: 39998070

Start: 3270642

End: 3271133

Strand: Reverse

Name: folK [H]

Synonym: GSU2979

Alternate gene names: 39998070

Gene position: 3271133-3270642 (Counterclockwise)

Preceding gene: 39998071

Following gene: 39998069

Centisome position: 85.76

GC content: 63.01

Gene sequence:

>492_bases
GTGGAATCCAACGTCTTCATAGCCCTCGGTTCGAACATGGGGGACCGGGAGCTGAACCTGCTGCGCGCAGTTGCCGAGAT
CGGCAAACTGCCGGAAACCCGAATAACCGCTCTTTCCGGCTTCTACGAAACCGAGCCGGTGGGGCCGGTGCCGGAACAGC
CCGACTTCCTCAACGCGGTCCTGCGGATCGAAACCTCGCTCACCCCTCACCGGCTCCTCGAAGAACTCCAGCGGATCGAA
ACCGGCCTGTTCGGCAGGCGCCGGGAGATGTATCAGGGGCCGCGTTCAATGGATCTGGATATCCTCCTCTACGGGAGCCT
GACCGTTGCCGTCGAAGGGCTCGTCATTCCCCATCCCCGGCTCCATCAGCGGCACTTCGTACTGGTCCCCTTGGCGGAGA
TTGCGCCGGATATGATTCATCCCGTGCAGGAGAAGCCGGTGCGGGAGCTGCTCGCTTCCCTGCCGCCGGGGGAGCGCGTC
ACCAAAACTTAG

Upstream 100 bases:

>100_bases
CAAGCTGGTCATGACCACCACCGGCGAGGAGTTGCACTGACGCTTTCCGGAGCGCGGCTCATGGATTGCAAAAATATCCC
CGTTATGCTCTAATCGTCCG

Downstream 100 bases:

>100_bases
GAGATCAGAGTGGGACTTATGCGTCTGCTCGTCTGGGCTGTCCTCATCTACGTGGGATACAAAATCGTCAAGGGCTTCGT
CTCCGACAAGAAGAAGGACG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MESNVFIALGSNMGDRELNLLRAVAEIGKLPETRITALSGFYETEPVGPVPEQPDFLNAVLRIETSLTPHRLLEELQRIE
TGLFGRRREMYQGPRSMDLDILLYGSLTVAVEGLVIPHPRLHQRHFVLVPLAEIAPDMIHPVQEKPVRELLASLPPGERV
TKT

Sequences:

>Translated_163_residues
MESNVFIALGSNMGDRELNLLRAVAEIGKLPETRITALSGFYETEPVGPVPEQPDFLNAVLRIETSLTPHRLLEELQRIE
TGLFGRRREMYQGPRSMDLDILLYGSLTVAVEGLVIPHPRLHQRHFVLVPLAEIAPDMIHPVQEKPVRELLASLPPGERV
TKT
>Mature_163_residues
MESNVFIALGSNMGDRELNLLRAVAEIGKLPETRITALSGFYETEPVGPVPEQPDFLNAVLRIETSLTPHRLLEELQRIE
TGLFGRRREMYQGPRSMDLDILLYGSLTVAVEGLVIPHPRLHQRHFVLVPLAEIAPDMIHPVQEKPVRELLASLPPGERV
TKT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=140, Percent_Identity=42.1428571428571, Blast_Score=114, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=155, Percent_Identity=35.4838709677419, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18291; Mature: 18291

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNVFIALGSNMGDRELNLLRAVAEIGKLPETRITALSGFYETEPVGPVPEQPDFLNAV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LRIETSLTPHRLLEELQRIETGLFGRRREMYQGPRSMDLDILLYGSLTVAVEGLVIPHPR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEHEECEECCCCC
LHQRHFVLVPLAEIAPDMIHPVQEKPVRELLASLPPGERVTKT
CCCCCEEEEEHHHHCHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MESNVFIALGSNMGDRELNLLRAVAEIGKLPETRITALSGFYETEPVGPVPEQPDFLNAV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LRIETSLTPHRLLEELQRIETGLFGRRREMYQGPRSMDLDILLYGSLTVAVEGLVIPHPR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEHEECEECCCCC
LHQRHFVLVPLAEIAPDMIHPVQEKPVRELLASLPPGERVTKT
CCCCCEEEEEHHHHCHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]