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The map label for this gene is tktA [C]

Identifier: 39998010

GI number: 39998010

Start: 3218541

End: 3219374

Strand: Reverse

Name: tktA [C]

Synonym: GSU2919

Alternate gene names: 39998010

Gene position: 3219374-3218541 (Counterclockwise)

Preceding gene: 39998012

Following gene: 39998009

Centisome position: 84.41

GC content: 62.95

Gene sequence:

>834_bases
GTGGACAGCGAAAAGATCAAGCAACTCGAAGAGACGGCCCGGCGGCTCAGGGTCGACATTGTCAAGACACTCCATTCGTC
CCAGTCGGGGCATACCGGTGGTTCCCTGTCTGCCATCGATATGGTGACCGCCCTCTACTTCCACGAAATGAAGCATGATC
CGACCAATCCGGCCTGGTCCGAACGGGACCGGTTCGTCCTCTGCAAGGGACATGCGGCGCCGGCTCTTTACGTGGCCCTT
GCCGCGACGGGGTATTTCCCGAAAGAAGATCTGATGATGCTGCGGCGTCTCGGCAGCCACCTGCAGGGACATCCGGACAG
CAAGCAGACCCCCGGTGTCGAGGTCTGCACCGGATCGCTGGGGCAGGGGCTTTCCATGGCCAACGGCATGGCCCTCGGCC
TGCGTCTTGACGGCAGTGCGAGCCGGGTCTACGCCCTGTTGGGCGACGGCGAACTCCAGGAGGGACAGGTCTGGGAAGCG
GCCATGGCCGCCGGTCACTTCAAGCTCGACAACCTCTGTGCCCTCATTGATGTGAACCGCCTCCAGATCGACGGCGAGGT
TGAAAAGGTCATGAACGTGGAGCCGGTCACCGACAAGTTCCGCGCCTTCGGCTGGAACGTCATCGATATCGACGGTCACG
ACATGGCCGCCATCGTCGGCGCGCTGGCCCAGGCCGCGGAGGTCAACGGCCGGCCGACCGCCATCGTTGCCCGCACCGTC
AAGGGGAAAGGTGTTTCCTTCTTCGAGAACAAGGCGTCCTACCACGGCGTCGCTCCCAGTGACGAGGAGCTTCCCAAGGC
ACTGGAGTGTCTCGGGGAGCAGTGCTACCTGTAA

Upstream 100 bases:

>100_bases
AAAACCGTCCAGCCTCGATGAGGTTATCCTCGATTTTCTCTTGGCAGACGATAAAGACTGAGACGAAATACACCCAACAT
CACCCACGGAAAGGACCATT

Downstream 100 bases:

>100_bases
CGTGCCGCGCGCCACATCACTGATCAGAAAGGACATTGACATATGAGCACCATGATCGCCACCCGCGACGCCTACGGCCA
GACCCTCGCCGAACTTGGAG

Product: transketolase, N-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MDSEKIKQLEETARRLRVDIVKTLHSSQSGHTGGSLSAIDMVTALYFHEMKHDPTNPAWSERDRFVLCKGHAAPALYVAL
AATGYFPKEDLMMLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSASRVYALLGDGELQEGQVWEA
AMAAGHFKLDNLCALIDVNRLQIDGEVEKVMNVEPVTDKFRAFGWNVIDIDGHDMAAIVGALAQAAEVNGRPTAIVARTV
KGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL

Sequences:

>Translated_277_residues
MDSEKIKQLEETARRLRVDIVKTLHSSQSGHTGGSLSAIDMVTALYFHEMKHDPTNPAWSERDRFVLCKGHAAPALYVAL
AATGYFPKEDLMMLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSASRVYALLGDGELQEGQVWEA
AMAAGHFKLDNLCALIDVNRLQIDGEVEKVMNVEPVTDKFRAFGWNVIDIDGHDMAAIVGALAQAAEVNGRPTAIVARTV
KGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL
>Mature_277_residues
MDSEKIKQLEETARRLRVDIVKTLHSSQSGHTGGSLSAIDMVTALYFHEMKHDPTNPAWSERDRFVLCKGHAAPALYVAL
AATGYFPKEDLMMLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSASRVYALLGDGELQEGQVWEA
AMAAGHFKLDNLCALIDVNRLQIDGEVEKVMNVEPVTDKFRAFGWNVIDIDGHDMAAIVGALAQAAEVNGRPTAIVARTV
KGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=256, Percent_Identity=44.140625, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI205277463, Length=268, Percent_Identity=42.1641791044776, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI4507521, Length=268, Percent_Identity=42.1641791044776, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI225637459, Length=256, Percent_Identity=32.8125, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI225637461, Length=256, Percent_Identity=32.421875, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI225637463, Length=216, Percent_Identity=33.7962962962963, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI48994911, Length=278, Percent_Identity=37.7697841726619, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788808, Length=278, Percent_Identity=37.7697841726619, Blast_Score=165, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17539652, Length=256, Percent_Identity=43.359375, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6325331, Length=256, Percent_Identity=41.40625, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6319593, Length=260, Percent_Identity=38.4615384615385, Blast_Score=146, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45551847, Length=273, Percent_Identity=38.0952380952381, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI45550715, Length=273, Percent_Identity=38.0952380952381, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24666278, Length=244, Percent_Identity=40.9836065573771, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24645119, Length=233, Percent_Identity=40.7725321888412, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29963; Mature: 29963

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSEKIKQLEETARRLRVDIVKTLHSSQSGHTGGSLSAIDMVTALYFHEMKHDPTNPAWS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
ERDRFVLCKGHAAPALYVALAATGYFPKEDLMMLRRLGSHLQGHPDSKQTPGVEVCTGSL
CCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCC
GQGLSMANGMALGLRLDGSASRVYALLGDGELQEGQVWEAAMAAGHFKLDNLCALIDVNR
CCCCHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCE
LQIDGEVEKVMNVEPVTDKFRAFGWNVIDIDGHDMAAIVGALAQAAEVNGRPTAIVARTV
EEECCHHHHHCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
KGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSEKIKQLEETARRLRVDIVKTLHSSQSGHTGGSLSAIDMVTALYFHEMKHDPTNPAWS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
ERDRFVLCKGHAAPALYVALAATGYFPKEDLMMLRRLGSHLQGHPDSKQTPGVEVCTGSL
CCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCC
GQGLSMANGMALGLRLDGSASRVYALLGDGELQEGQVWEAAMAAGHFKLDNLCALIDVNR
CCCCHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCE
LQIDGEVEKVMNVEPVTDKFRAFGWNVIDIDGHDMAAIVGALAQAAEVNGRPTAIVARTV
EEECCHHHHHCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
KGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]