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The map label for this gene is dxs [C]

Identifier: 39998009

GI number: 39998009

Start: 3217554

End: 3218498

Strand: Reverse

Name: dxs [C]

Synonym: GSU2918

Alternate gene names: 39998009

Gene position: 3218498-3217554 (Counterclockwise)

Preceding gene: 39998010

Following gene: 39998008

Centisome position: 84.38

GC content: 64.02

Gene sequence:

>945_bases
ATGAGCACCATGATCGCCACCCGCGACGCCTACGGCCAGACCCTCGCCGAACTTGGAGAGGAGAACGGCAGTGTCGTCGT
CCTCGACGCCGACCTGTCCGGCTCCACCAAGACGTCGGTCTTTGCCAAGAAATTCCCGGACCGTTTCTTCAATATGGGGA
TCGCCGAGGCCAATATGGTCGGCACGGCCGCGGGCCTTGCCGCGGCAGGTAAAATCCCCTTTGTATCAACGTTCGCTATC
TTTGCCGTGGGACGGGCCTGGGAGCAGGTTCGCCAGTCGCTGGCCTATCCCAAGGCCAACGTCAAGGTGGTGGCCACCCA
CGGCGGCATCACCGTTGGCGAGGACGGTGGCTCCCACCAGTCGGTGGAGGATATTGCCATCATGCGGGCGGTGCCGAACA
TGACGGTTATCGTCCCGGCCGATGGCCCGGAAACGGCCAGGGCGATCCGTGCCGCCGCCGCCCATCGCGGCCCGGTATAC
GTACGCCTGGGCCGCAACAAGGTCCCCACCGTCACCTCGACCGATACTCCCTTCGAGATCGGTAAAGGGGTCCAGCTTGC
GGACGGTACGGACCTGACCTTCGTAACCACCGGCCTCATGACCGCTCAGGCTTTGGCCGCCGCGGAACTCCTGTCTCAGG
AGGGTATCTCGGCGCGGGTGATCCATATGGCCACCATCAAGCCTCTGGACGGCGAGATTCTGCAGCGCGCCGCTCAAGAA
ACCGGTGCCATCGTTACCGCCGAAGAGCATTCCATAGTGGGCGGGCTTGGTGGGGCCGCTGCCGAATTCCTTGCGGAGAA
CTGTCCGGTGCCCCTCAAGCGGGTCGGAATTAATGACCGCTTCGGCCTGTCCGGCAAAGCCGAGGAACTGCTGAAATATT
TCGGACTCATGCCGGCCGATCTGGCCGAGGCGGGGCGCGAGGTGCTCACGCGCAAGCGGCCCTGA

Upstream 100 bases:

>100_bases
CAGTGACGAGGAGCTTCCCAAGGCACTGGAGTGTCTCGGGGAGCAGTGCTACCTGTAACGTGCCGCGCGCCACATCACTG
ATCAGAAAGGACATTGACAT

Downstream 100 bases:

>100_bases
GGAACGAGGGTGAGGAGAATCCTTGCATCCTCCGGCGGCTTCACCTTTGTCGGCGCCCTGATGATCGTGATTGTCATGGG
AATCATGCTGGGGATCGTGG

Product: transketolase, C-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSTMIATRDAYGQTLAELGEENGSVVVLDADLSGSTKTSVFAKKFPDRFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAI
FAVGRAWEQVRQSLAYPKANVKVVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETARAIRAAAAHRGPVY
VRLGRNKVPTVTSTDTPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAELLSQEGISARVIHMATIKPLDGEILQRAAQE
TGAIVTAEEHSIVGGLGGAAAEFLAENCPVPLKRVGINDRFGLSGKAEELLKYFGLMPADLAEAGREVLTRKRP

Sequences:

>Translated_314_residues
MSTMIATRDAYGQTLAELGEENGSVVVLDADLSGSTKTSVFAKKFPDRFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAI
FAVGRAWEQVRQSLAYPKANVKVVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETARAIRAAAAHRGPVY
VRLGRNKVPTVTSTDTPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAELLSQEGISARVIHMATIKPLDGEILQRAAQE
TGAIVTAEEHSIVGGLGGAAAEFLAENCPVPLKRVGINDRFGLSGKAEELLKYFGLMPADLAEAGREVLTRKRP
>Mature_313_residues
STMIATRDAYGQTLAELGEENGSVVVLDADLSGSTKTSVFAKKFPDRFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAIF
AVGRAWEQVRQSLAYPKANVKVVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETARAIRAAAAHRGPVYV
RLGRNKVPTVTSTDTPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAELLSQEGISARVIHMATIKPLDGEILQRAAQET
GAIVTAEEHSIVGGLGGAAAEFLAENCPVPLKRVGINDRFGLSGKAEELLKYFGLMPADLAEAGREVLTRKRP

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=38.2636655948553, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=38.2636655948553, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI225637463, Length=296, Percent_Identity=37.1621621621622, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI225637461, Length=296, Percent_Identity=37.1621621621622, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI225637459, Length=296, Percent_Identity=37.1621621621622, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI133778974, Length=298, Percent_Identity=35.9060402684564, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI291084858, Length=258, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156564403, Length=269, Percent_Identity=28.2527881040892, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=291, Percent_Identity=32.3024054982818, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI48994911, Length=312, Percent_Identity=29.4871794871795, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788808, Length=317, Percent_Identity=29.6529968454259, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539652, Length=296, Percent_Identity=39.1891891891892, Blast_Score=187, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6325331, Length=273, Percent_Identity=31.8681318681319, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319593, Length=258, Percent_Identity=32.1705426356589, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551847, Length=309, Percent_Identity=36.2459546925566, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45550715, Length=309, Percent_Identity=36.2459546925566, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24645119, Length=309, Percent_Identity=36.2459546925566, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24666278, Length=311, Percent_Identity=34.0836012861736, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32832; Mature: 32701

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMIATRDAYGQTLAELGEENGSVVVLDADLSGSTKTSVFAKKFPDRFFNMGIAEANMV
CCCCEECCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHCCCCHHHHH
GTAAGLAAAGKIPFVSTFAIFAVGRAWEQVRQSLAYPKANVKVVATHGGITVGEDGGSHQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCC
SVEDIAIMRAVPNMTVIVPADGPETARAIRAAAAHRGPVYVRLGRNKVPTVTSTDTPFEI
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCEECCCCCCHHH
GKGVQLADGTDLTFVTTGLMTAQALAAAELLSQEGISARVIHMATIKPLDGEILQRAAQE
CCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
TGAIVTAEEHSIVGGLGGAAAEFLAENCPVPLKRVGINDRFGLSGKAEELLKYFGLMPAD
CCCEEEECCCCEECCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCHH
LAEAGREVLTRKRP
HHHHHHHHHHCCCC
>Mature Secondary Structure 
STMIATRDAYGQTLAELGEENGSVVVLDADLSGSTKTSVFAKKFPDRFFNMGIAEANMV
CCCEECCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHCCCCHHHHH
GTAAGLAAAGKIPFVSTFAIFAVGRAWEQVRQSLAYPKANVKVVATHGGITVGEDGGSHQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCC
SVEDIAIMRAVPNMTVIVPADGPETARAIRAAAAHRGPVYVRLGRNKVPTVTSTDTPFEI
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCEECCCCCCHHH
GKGVQLADGTDLTFVTTGLMTAQALAAAELLSQEGISARVIHMATIKPLDGEILQRAAQE
CCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
TGAIVTAEEHSIVGGLGGAAAEFLAENCPVPLKRVGINDRFGLSGKAEELLKYFGLMPAD
CCCEEEECCCCEECCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCHH
LAEAGREVLTRKRP
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]