Click here to switch to the map view.

The map label for this gene is nrdZ [H]

Identifier: 39996969

GI number: 39996969

Start: 2047929

End: 2050160

Strand: Direct

Name: nrdZ [H]

Synonym: GSU1871

Alternate gene names: 39996969

Gene position: 2047929-2050160 (Clockwise)

Preceding gene: 39996961

Following gene: 39996970

Centisome position: 53.69

GC content: 60.75

Gene sequence:

>2232_bases
ATGGCAGAAACGATGACGAAGGCCACCGATATCCCCGGACTCTCGAAAAATGCAGTGACGGTCCTCGAGAAGCGCTACCT
CAAGCGCGATACCGGGGGCAACGTGCTTGAAACTCCGGTGGACATGTTTCAACGGGTGGCCCGATCAATCGCCGAAGCCG
ACAAGAACTTCGACAAGAAGGCGGATGTCAAGGCTCTGGCCGCACAATTCTACGAGCTGATGACCTCCTTCGAGTTCCTC
CCCAACTCGCCGACCCTCATGAATGCCGGCCGCGAGCTGGGCCAGCTCTCCGCCTGCTTCGTGCTGCCGGTGGGCGATTC
CATGGAAGACATCTTCGACGCGGTCAAGTACACGGCCCTGATCCACAAGTCGGGCGGCGGCACCGGATTTTCCTTTTCCC
GCCTCCGTCCCGCCCACGATGTGGTCCGCTCCACGTCGGGAATCTCCAGTGGGCCTATTTCGTTCATGCGGGTCTTCGAT
GCCGCCACCGAAACCATCAAGCAAGGAGGAACGAGGCGCGGCGCCAACATGGGAATCCTGCGGGTGGATCACCCGGACAT
CATGGATTTCATCATGTGCAAGGACGATCAAAAGCACCTGAACAACTTCAATATCTCCGTGGGGCTCACCGAAGCCTTCA
TGGAAGCAGTGGAGCGGGATGCCGACTATGACCTCATCAACCCCCGGGACGGCAAACCCTGCGGCACCCTGAACGCCCGC
AAGGTGTTCAGCCGGATCGTGAAGCAGGCATGGAAGAACGGCGAGCCGGGCATCATCTTCCTGGATCGCCTCAACAAGGA
CAACCCGACCCCCCACGTGGGCGTCATCGAGTCCACCAACCCCTGCGGCGAACAGCCCCTGCTCCCCTATGAATCATGCA
ACCTGGGCTCCATCAACCTGGGCAAGATGGTGAAGAACGGCGACGTTAACTGGGACCGTCTGCGGGACGTGGTGCGGCTG
GCGGTACACTTCCTGGATAACGTGATCGAGGTGAACAACTACCCTCTCCCACAGATCAGCGAGATGACCCGCGCTAACCG
CAAGATAGGCCTCGGCGTCATGGGCTGGGCCGACATGCTCATCCTGCTGGGCATTCCCTACAATTCACCGCAGGCCATCA
GCCTGGGCGAAAAGGTGATGCGCTTCATCAACGACGAAGGGCATGTCTATTCCCGTGAACTGGCAGCCGTGCGGGGATCG
TTCCCGAACTTCGCCGGCTCCATCTACGACCGGGCCAGCGAAGGCCCTATCCGCAACGCCACTGTGACCACCATTGCGCC
CACGGGCACCATATCCATCATCGCCAATGCCTCCAGCGGCGTGGAACCGCTTTTTGCCGTCTCTTTCATCCGCCAAGTGC
TCGACAAGAACATTCTGGTGGAAGTAAACCCGATTTTCGAGGAAGTTGCCCGCCAGCGGGGGTTTTACTCCGAGGAACTG
ATGCAGAAGATCGCACGGCACGGCACCATCCACGATCTGCCCGAGATCCCGGAGGATATCCGGAAGATATTTGTCACCGC
CCACGACATCACACCGGAAGACCACATCGAGATGCAGGCGGCTTTCCAGAAGTACACCGACAACGCCGTGTCCAAGACGG
TTAACTTCCCCAATAGCGCGGCCATCGAGGATGTGGAGAAAGTCTACCGGCTGGCCTACAAATCGGGCTGCAAGGGTGTA
ACCATCTACCGCGACGGCTCCCGCGACGAACAGGTCCTCTCCACCGGTGTCAAAGAGGACAAGGAGAAGGTGGTTCAAAC
CGAGGAGAAGCGGGCCGTGAAGCGCGATCGTCCCAAGGCGCTCAAGGGGTGGACCTACCAGATGCAGACGGGGTGCGGCC
CCCTGTATGTGACCATCAACGAGGACAAGGCCGGCCTCTTCGAGTTGTTCACAACCATGGGCAAGGCTGGCGGATGCGCC
TCTTCCCAGTGCGAGGCCATCGGCCGGATGGTTTCACTGGCTTGGCGCAGCGGCGTTCAGGCCCGCCAGGTGATCAAGCA
GCTCCTCGGCATCTCCTGCCACCTCCCCGCCGGTTTTGGCGACAACAAGGTGCTGTCCTGCGCCGATGCTGTTGCCAAGG
CGATCCAGGCCCACATGCAGGCAGCCGGTTACGATGTCAGCCTGGAAGCCCAGGCCCCCGAACGCGGCGCCTGCCCCGAG
TGCGGCGGCATTGTTGAGCATGAGGGCGGCTGCGCGGTCTGCCGGGTCTGTGGCTATTCGGAGTGCGCGTAG

Upstream 100 bases:

>100_bases
GCTTGACACACCATATATATTGTGGCTATCTTTTCACCGCAACACAACATATATGGTTCCCACCAACAATACATCCCCAC
GAACCAAGGAGAATGAAATC

Downstream 100 bases:

>100_bases
CACCACCCATTCCAGAAGGAGGCGTTATGAAAAGAATCCTCGTGGCTCTCGCCCTGACGTTCGTTGCCGGCTTCGCGTTT
GCTGCCGATGAGAATCCGCT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MAETMTKATDIPGLSKNAVTVLEKRYLKRDTGGNVLETPVDMFQRVARSIAEADKNFDKKADVKALAAQFYELMTSFEFL
PNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKYTALIHKSGGGTGFSFSRLRPAHDVVRSTSGISSGPISFMRVFD
AATETIKQGGTRRGANMGILRVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLINPRDGKPCGTLNAR
KVFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHVGVIESTNPCGEQPLLPYESCNLGSINLGKMVKNGDVNWDRLRDVVRL
AVHFLDNVIEVNNYPLPQISEMTRANRKIGLGVMGWADMLILLGIPYNSPQAISLGEKVMRFINDEGHVYSRELAAVRGS
FPNFAGSIYDRASEGPIRNATVTTIAPTGTISIIANASSGVEPLFAVSFIRQVLDKNILVEVNPIFEEVARQRGFYSEEL
MQKIARHGTIHDLPEIPEDIRKIFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNSAAIEDVEKVYRLAYKSGCKGV
TIYRDGSRDEQVLSTGVKEDKEKVVQTEEKRAVKRDRPKALKGWTYQMQTGCGPLYVTINEDKAGLFELFTTMGKAGGCA
SSQCEAIGRMVSLAWRSGVQARQVIKQLLGISCHLPAGFGDNKVLSCADAVAKAIQAHMQAAGYDVSLEAQAPERGACPE
CGGIVEHEGGCAVCRVCGYSECA

Sequences:

>Translated_743_residues
MAETMTKATDIPGLSKNAVTVLEKRYLKRDTGGNVLETPVDMFQRVARSIAEADKNFDKKADVKALAAQFYELMTSFEFL
PNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKYTALIHKSGGGTGFSFSRLRPAHDVVRSTSGISSGPISFMRVFD
AATETIKQGGTRRGANMGILRVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLINPRDGKPCGTLNAR
KVFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHVGVIESTNPCGEQPLLPYESCNLGSINLGKMVKNGDVNWDRLRDVVRL
AVHFLDNVIEVNNYPLPQISEMTRANRKIGLGVMGWADMLILLGIPYNSPQAISLGEKVMRFINDEGHVYSRELAAVRGS
FPNFAGSIYDRASEGPIRNATVTTIAPTGTISIIANASSGVEPLFAVSFIRQVLDKNILVEVNPIFEEVARQRGFYSEEL
MQKIARHGTIHDLPEIPEDIRKIFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNSAAIEDVEKVYRLAYKSGCKGV
TIYRDGSRDEQVLSTGVKEDKEKVVQTEEKRAVKRDRPKALKGWTYQMQTGCGPLYVTINEDKAGLFELFTTMGKAGGCA
SSQCEAIGRMVSLAWRSGVQARQVIKQLLGISCHLPAGFGDNKVLSCADAVAKAIQAHMQAAGYDVSLEAQAPERGACPE
CGGIVEHEGGCAVCRVCGYSECA
>Mature_742_residues
AETMTKATDIPGLSKNAVTVLEKRYLKRDTGGNVLETPVDMFQRVARSIAEADKNFDKKADVKALAAQFYELMTSFEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKYTALIHKSGGGTGFSFSRLRPAHDVVRSTSGISSGPISFMRVFDA
ATETIKQGGTRRGANMGILRVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLINPRDGKPCGTLNARK
VFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHVGVIESTNPCGEQPLLPYESCNLGSINLGKMVKNGDVNWDRLRDVVRLA
VHFLDNVIEVNNYPLPQISEMTRANRKIGLGVMGWADMLILLGIPYNSPQAISLGEKVMRFINDEGHVYSRELAAVRGSF
PNFAGSIYDRASEGPIRNATVTTIAPTGTISIIANASSGVEPLFAVSFIRQVLDKNILVEVNPIFEEVARQRGFYSEELM
QKIARHGTIHDLPEIPEDIRKIFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNSAAIEDVEKVYRLAYKSGCKGVT
IYRDGSRDEQVLSTGVKEDKEKVVQTEEKRAVKRDRPKALKGWTYQMQTGCGPLYVTINEDKAGLFELFTTMGKAGGCAS
SQCEAIGRMVSLAWRSGVQARQVIKQLLGISCHLPAGFGDNKVLSCADAVAKAIQAHMQAAGYDVSLEAQAPERGACPEC
GGIVEHEGGCAVCRVCGYSECA

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=605, Percent_Identity=27.4380165289256, Blast_Score=217, Evalue=4e-56,
Organism=Escherichia coli, GI1789030, Length=628, Percent_Identity=25.9554140127389, Blast_Score=157, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17555242, Length=605, Percent_Identity=26.9421487603306, Blast_Score=214, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6322123, Length=669, Percent_Identity=26.0089686098655, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320914, Length=608, Percent_Identity=27.1381578947368, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17352481, Length=605, Percent_Identity=26.1157024793388, Blast_Score=198, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 81475; Mature: 81344

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETMTKATDIPGLSKNAVTVLEKRYLKRDTGGNVLETPVDMFQRVARSIAEADKNFDKK
CCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
ADVKALAAQFYELMTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKYTAL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHH
IHKSGGGTGFSFSRLRPAHDVVRSTSGISSGPISFMRVFDAATETIKQGGTRRGANMGIL
EEECCCCCCCCHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
RVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLINPRDGKPCGTLNAR
EECCCHHHHHHHCCCCHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
KVFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHVGVIESTNPCGEQPLLPYESCNLGSINL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCH
GKMVKNGDVNWDRLRDVVRLAVHFLDNVIEVNNYPLPQISEMTRANRKIGLGVMGWADML
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHH
ILLGIPYNSPQAISLGEKVMRFINDEGHVYSRELAAVRGSFPNFAGSIYDRASEGPIRNA
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCC
TVTTIAPTGTISIIANASSGVEPLFAVSFIRQVLDKNILVEVNPIFEEVARQRGFYSEEL
EEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHHH
MQKIARHGTIHDLPEIPEDIRKIFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNSA
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AIEDVEKVYRLAYKSGCKGVTIYRDGSRDEQVLSTGVKEDKEKVVQTEEKRAVKRDRPKA
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCH
LKGWTYQMQTGCGPLYVTINEDKAGLFELFTTMGKAGGCASSQCEAIGRMVSLAWRSGVQ
HCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
ARQVIKQLLGISCHLPAGFGDNKVLSCADAVAKAIQAHMQAAGYDVSLEAQAPERGACPE
HHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
CGGIVEHEGGCAVCRVCGYSECA
CCCCEECCCCCCEEECCCCCCCC
>Mature Secondary Structure 
AETMTKATDIPGLSKNAVTVLEKRYLKRDTGGNVLETPVDMFQRVARSIAEADKNFDKK
CCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
ADVKALAAQFYELMTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKYTAL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHH
IHKSGGGTGFSFSRLRPAHDVVRSTSGISSGPISFMRVFDAATETIKQGGTRRGANMGIL
EEECCCCCCCCHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
RVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLINPRDGKPCGTLNAR
EECCCHHHHHHHCCCCHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
KVFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHVGVIESTNPCGEQPLLPYESCNLGSINL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCH
GKMVKNGDVNWDRLRDVVRLAVHFLDNVIEVNNYPLPQISEMTRANRKIGLGVMGWADML
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHH
ILLGIPYNSPQAISLGEKVMRFINDEGHVYSRELAAVRGSFPNFAGSIYDRASEGPIRNA
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCC
TVTTIAPTGTISIIANASSGVEPLFAVSFIRQVLDKNILVEVNPIFEEVARQRGFYSEEL
EEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHHH
MQKIARHGTIHDLPEIPEDIRKIFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNSA
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AIEDVEKVYRLAYKSGCKGVTIYRDGSRDEQVLSTGVKEDKEKVVQTEEKRAVKRDRPKA
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCH
LKGWTYQMQTGCGPLYVTINEDKAGLFELFTTMGKAGGCASSQCEAIGRMVSLAWRSGVQ
HCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
ARQVIKQLLGISCHLPAGFGDNKVLSCADAVAKAIQAHMQAAGYDVSLEAQAPERGACPE
HHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
CGGIVEHEGGCAVCRVCGYSECA
CCCCEECCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]