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The map label for this gene is atoS [H]

Identifier: 39995481

GI number: 39995481

Start: 407414

End: 408916

Strand: Reverse

Name: atoS [H]

Synonym: GSU0373

Alternate gene names: 39995481

Gene position: 408916-407414 (Counterclockwise)

Preceding gene: 39995492

Following gene: 39995480

Centisome position: 10.72

GC content: 61.61

Gene sequence:

>1503_bases
TTGCCACCCCCTTGGCCCTGGTGTATAATCCCGCCGTACCGCCCACAAGGACTCGATTTTTTACGTCGAACGCCCACCAG
AGGCCCCATGAGACTCAATACCAAGCTGGTGATGATCATGCTGACGCTGCTCGTCATCGCCGTCGTCACCCTCTTCGTGC
TCAACCAGTACAGTCAGAACGAAATGGTGCAGGAGATCCAGGAGAGCTCCTCCTTCGTCTCCCAGGCCATCCAGATGAGC
GTCGAGGATCTGACGTCCGAGTTCGAGCCCGACCCGGAGCGGCTTGCCCGCTACATGAAAGAGGCACGGGTCAGGGGGGT
CAAGGAGATCAGCATCATCAGCAACGAAGGGGAGATCATCGACTCGTCCGACCCTTCCAAGGTGGGCAAGAAGCGCGACA
TCAAGAAGATGGAAAAGGGGCTCAGGGCGGCACCCGAATCCCGTCGGGAACGCGCCACCGCCAACCGCTCCTATGAGCTG
CTGGTGCCGGTCATCGTCGGCGACCAGCAGCTGGGATACGTCCAGATCAACCTGCTGCTGGACAATATCAGGACCATCCA
GCATGAGAACTTCGTGAACCGGGTGGTGGCCACCTCGCTGGTCTTTCTGCTGGGGATCATCTTCACCATTTTCCTGGCAA
CGCGCTACACGGCGCCCATCAACCGGCTGGCCGCCCAGGTCCGGCGGGTGGCCGACGGCGACCTGACCGTGAGCTTCCCG
GTGGCGGGCAGTGACGAGATCGGCGAGTTGGGGCGGAACTTCAACGAGATGGTTACCAAGCTCCAGGAACGGGAAAACCT
TGAAAAACGGCTCTACGAGGCAGAACACCTCTCCAAGGTGGGACAGCTCGCGTCGGGCATCGCCCACGAAATACGCAACC
CTCTCAACTACATCAGCCTTGCCGTGGATCATCTCAAGGGCGAATTCGTGGCTGCCTGCCCCGACAAGGGCGAGCGCTTC
GTTCCTCTGGCGGAAAAGATCAAGGAGGAGGTGCGGCGGGCCAACTACCTGGTGGTCAACTTCATGAACTATGGCCGCCC
GCTGAAGCTGCGCATCGGTGAGGTCTGCTACCGTGAGCTGATCGACCGGGCCCTACCGCTGCTCCGGGAGCGTCTCGACG
AACAGCGGATCGCCGTGGCCACCGAAATCCCGCCGGATCTCCCTCCCATGCGCGCGGACGGCGAGATGCTCCGCAACTGC
GTCTTCAACTTCGTGACCAACGCCATCCAGGCCATGCCGGGGGGCGGTACCATCACCCTCGGCGCCTCCTTTGACCGGGA
AACGGAAACATTCCACCTTACCTTTACCGACCAGGGGGTCGGTATCCCGCCGGAGGACCTGCCGAAAATATTCCAGCCCT
GGTTCACCAGCAAGGAAGCGGGGATCGGCCTGGGTCTCGCCATCACCGAGCGGATCATCCGCGAGCACGGCGGTGAGATC
CTCGTGGAAAGCACACCGGCGCAGGGCACCACATTTACCGTCATTCTCCGGGGCGGGCGATGA

Upstream 100 bases:

>100_bases
ACAGCTTCCATCCTCCTCACCCCCATCTGCCGGGCGGTCTGGTCGTTCCGGCCGATCATAGCAGAGTTTATCCTACAAAA
GAAGCGCTGGGAGAGCCGCC

Downstream 100 bases:

>100_bases
CTTCACCGGAAAACACCCTATACTTATGCAGAACGGAGAAACCATGCCCGCAACCATACTGATCGTCGACGATGAACGGG
GGCAGCGCGAGATCCTCCAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MPPPWPWCIIPPYRPQGLDFLRRTPTRGPMRLNTKLVMIMLTLLVIAVVTLFVLNQYSQNEMVQEIQESSSFVSQAIQMS
VEDLTSEFEPDPERLARYMKEARVRGVKEISIISNEGEIIDSSDPSKVGKKRDIKKMEKGLRAAPESRRERATANRSYEL
LVPVIVGDQQLGYVQINLLLDNIRTIQHENFVNRVVATSLVFLLGIIFTIFLATRYTAPINRLAAQVRRVADGDLTVSFP
VAGSDEIGELGRNFNEMVTKLQERENLEKRLYEAEHLSKVGQLASGIAHEIRNPLNYISLAVDHLKGEFVAACPDKGERF
VPLAEKIKEEVRRANYLVVNFMNYGRPLKLRIGEVCYRELIDRALPLLRERLDEQRIAVATEIPPDLPPMRADGEMLRNC
VFNFVTNAIQAMPGGGTITLGASFDRETETFHLTFTDQGVGIPPEDLPKIFQPWFTSKEAGIGLGLAITERIIREHGGEI
LVESTPAQGTTFTVILRGGR

Sequences:

>Translated_500_residues
MPPPWPWCIIPPYRPQGLDFLRRTPTRGPMRLNTKLVMIMLTLLVIAVVTLFVLNQYSQNEMVQEIQESSSFVSQAIQMS
VEDLTSEFEPDPERLARYMKEARVRGVKEISIISNEGEIIDSSDPSKVGKKRDIKKMEKGLRAAPESRRERATANRSYEL
LVPVIVGDQQLGYVQINLLLDNIRTIQHENFVNRVVATSLVFLLGIIFTIFLATRYTAPINRLAAQVRRVADGDLTVSFP
VAGSDEIGELGRNFNEMVTKLQERENLEKRLYEAEHLSKVGQLASGIAHEIRNPLNYISLAVDHLKGEFVAACPDKGERF
VPLAEKIKEEVRRANYLVVNFMNYGRPLKLRIGEVCYRELIDRALPLLRERLDEQRIAVATEIPPDLPPMRADGEMLRNC
VFNFVTNAIQAMPGGGTITLGASFDRETETFHLTFTDQGVGIPPEDLPKIFQPWFTSKEAGIGLGLAITERIIREHGGEI
LVESTPAQGTTFTVILRGGR
>Mature_499_residues
PPPWPWCIIPPYRPQGLDFLRRTPTRGPMRLNTKLVMIMLTLLVIAVVTLFVLNQYSQNEMVQEIQESSSFVSQAIQMSV
EDLTSEFEPDPERLARYMKEARVRGVKEISIISNEGEIIDSSDPSKVGKKRDIKKMEKGLRAAPESRRERATANRSYELL
VPVIVGDQQLGYVQINLLLDNIRTIQHENFVNRVVATSLVFLLGIIFTIFLATRYTAPINRLAAQVRRVADGDLTVSFPV
AGSDEIGELGRNFNEMVTKLQERENLEKRLYEAEHLSKVGQLASGIAHEIRNPLNYISLAVDHLKGEFVAACPDKGERFV
PLAEKIKEEVRRANYLVVNFMNYGRPLKLRIGEVCYRELIDRALPLLRERLDEQRIAVATEIPPDLPPMRADGEMLRNCV
FNFVTNAIQAMPGGGTITLGASFDRETETFHLTFTDQGVGIPPEDLPKIFQPWFTSKEAGIGLGLAITERIIREHGGEIL
VESTPAQGTTFTVILRGGR

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=301, Percent_Identity=30.5647840531561, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=34.3220338983051, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788393, Length=293, Percent_Identity=25.2559726962457, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081816, Length=334, Percent_Identity=27.5449101796407, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789149, Length=373, Percent_Identity=24.9329758713137, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790300, Length=255, Percent_Identity=29.0196078431373, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=292, Percent_Identity=27.3972602739726, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994928, Length=137, Percent_Identity=31.3868613138686, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=305, Percent_Identity=25.5737704918033, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=25.78125, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56294; Mature: 56163

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPWPWCIIPPYRPQGLDFLRRTPTRGPMRLNTKLVMIMLTLLVIAVVTLFVLNQYSQN
CCCCCCEEEECCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCHH
EMVQEIQESSSFVSQAIQMSVEDLTSEFEPDPERLARYMKEARVRGVKEISIISNEGEII
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEEEECCCCCEE
DSSDPSKVGKKRDIKKMEKGLRAAPESRRERATANRSYELLVPVIVGDQQLGYVQINLLL
CCCCCHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEEH
DNIRTIQHENFVNRVVATSLVFLLGIIFTIFLATRYTAPINRLAAQVRRVADGDLTVSFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEC
VAGSDEIGELGRNFNEMVTKLQERENLEKRLYEAEHLSKVGQLASGIAHEIRNPLNYISL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDHLKGEFVAACPDKGERFVPLAEKIKEEVRRANYLVVNFMNYGRPLKLRIGEVCYREL
HHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEHHHHHHHHHHH
IDRALPLLRERLDEQRIAVATEIPPDLPPMRADGEMLRNCVFNFVTNAIQAMPGGGTITL
HHHHHHHHHHHHCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
GASFDRETETFHLTFTDQGVGIPPEDLPKIFQPWFTSKEAGIGLGLAITERIIREHGGEI
CCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEE
LVESTPAQGTTFTVILRGGR
EEECCCCCCCEEEEEEECCC
>Mature Secondary Structure 
PPPWPWCIIPPYRPQGLDFLRRTPTRGPMRLNTKLVMIMLTLLVIAVVTLFVLNQYSQN
CCCCCEEEECCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCHH
EMVQEIQESSSFVSQAIQMSVEDLTSEFEPDPERLARYMKEARVRGVKEISIISNEGEII
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEEEECCCCCEE
DSSDPSKVGKKRDIKKMEKGLRAAPESRRERATANRSYELLVPVIVGDQQLGYVQINLLL
CCCCCHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEEH
DNIRTIQHENFVNRVVATSLVFLLGIIFTIFLATRYTAPINRLAAQVRRVADGDLTVSFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEC
VAGSDEIGELGRNFNEMVTKLQERENLEKRLYEAEHLSKVGQLASGIAHEIRNPLNYISL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDHLKGEFVAACPDKGERFVPLAEKIKEEVRRANYLVVNFMNYGRPLKLRIGEVCYREL
HHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEHHHHHHHHHHH
IDRALPLLRERLDEQRIAVATEIPPDLPPMRADGEMLRNCVFNFVTNAIQAMPGGGTITL
HHHHHHHHHHHHCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
GASFDRETETFHLTFTDQGVGIPPEDLPKIFQPWFTSKEAGIGLGLAITERIIREHGGEI
CCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEE
LVESTPAQGTTFTVILRGGR
EEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]