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The map label for this gene is atoC [H]

Identifier: 39995480

GI number: 39995480

Start: 406003

End: 407388

Strand: Reverse

Name: atoC [H]

Synonym: GSU0372

Alternate gene names: 39995480

Gene position: 407388-406003 (Counterclockwise)

Preceding gene: 39995481

Following gene: 39995479

Centisome position: 10.68

GC content: 63.71

Gene sequence:

>1386_bases
ATGCAGAACGGAGAAACCATGCCCGCAACCATACTGATCGTCGACGATGAACGGGGGCAGCGCGAGATCCTCCAGACCAT
CCTGGAGGGAGAACGCTACGAAACCACGACGGCGGCCGGCGGACAGGAGGCCCTGGCCTTGCTGGACGAGCGGGAGTTCG
ATGTCATCCTCACGGATCTGAAGATGCAGGGAATGTCGGGAATGGAGCTGCTGGAGCGGCTGTTGGCGGCTGACCCGCAG
CAGTGCATCATCATGATGACTGCCCACGGCACCGTTGACTCGGCAGTGGAAGCTATGAAGAAAGGGGCCTTTGACTATCT
GGAAAAGCCCCTGGAGCGGGACACCCTGCTGCTCACCCTGCGGCGGGCGGTAGAGCGGGTCCGGTTGCTGAAGGAGAACC
GGGCGCTCCACAAAAAACTGGAGGAAACGGGCGCCATTCCGGACATCATCGGCGAGCACCCCAAGATGAAAGAGGTCTTT
CGGATCGTCACCAAGATCGCGCCCACCGCCTCCACGGTCCTCATCCAGGGCGAATCGGGCACCGGCAAGGAGCTGGTGGC
CAGCGCCATCCACGAAAGGAGCCCCCGGGCGGACAAGCCCTTTTTCGCCATCAACTGTGCCGCCATCCCGGAAACCCTCA
TGGAGAGCGAGCTGTTCGGCCACGAGAAGGGTGCCTTCACCGGCGCCAGTTCCCGCGAGATCGGCATCTTCGAGGCCGCG
AACGGCGGCACCGTTTTTCTGGACGAGATCGGGGAGATGAGCGTGGCCATGCAGGCGAAACTCCTGCGGGCGATCCAGGC
CAAGGAGATCCGGCGGGTGGGGGGCAAGGTCAACATCCCGGTGGATGTCCGGATCATCTCGGCCACCAACCGTGACCTGG
AAGCGGAGATCCGCCGGGGCAACTTCCGGGAGGACCTCTTCTATCGCCTTAACGTGATCCGGATCAGCCTTCCGCCGCTG
CGGGAACGGGGAAGCGACATAGCTGCCCTGACCGACTTCTTCGTGGCGAAATACCGGGGCGATACGGGGGTGAAGGGGCT
CTCCCGCGCCGCCCTGAAGCTCCTCATGAACTACAGCTGGCCCGGCAACGTCCGTCAGCTGGAGTCGGTGATCGAGCGGG
GCATCCTCATGGCGGAGGGAGAGCTGGTCGAACCCGGCGACCTGCCGGCGGAGATCGGCGAAGGGGTGTCGCCGGGCGGC
GGACTCCCCTTCGAGCTTCCCGCCGACGGCATCCAGTTCGAGGAACTGGAAAAGAACCTGATCATCAAGGCCATGGAGCG
GGCCGGTGGGGTCATTGCAAAGGCGGCGCCGCTGCTCGGCATGAGCTACAAAACACTCCAGTACCGGCTGGAAAAGTTCG
GCATAACCCGGGACCAGGGGCCGTGA

Upstream 100 bases:

>100_bases
GGCGGTGAGATCCTCGTGGAAAGCACACCGGCGCAGGGCACCACATTTACCGTCATTCTCCGGGGCGGGCGATGACTTCA
CCGGAAAACACCCTATACTT

Downstream 100 bases:

>100_bases
ACCGGCTACCGGTGCCAGGGACGGAAGTTCCCGTCAGCGAAGACCGGGGCGATAGGACCTGATAACGGCCGCTTAACCGC
AGCAACTCTGCGTAAGACAA

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MQNGETMPATILIVDDERGQREILQTILEGERYETTTAAGGQEALALLDEREFDVILTDLKMQGMSGMELLERLLAADPQ
QCIIMMTAHGTVDSAVEAMKKGAFDYLEKPLERDTLLLTLRRAVERVRLLKENRALHKKLEETGAIPDIIGEHPKMKEVF
RIVTKIAPTASTVLIQGESGTGKELVASAIHERSPRADKPFFAINCAAIPETLMESELFGHEKGAFTGASSREIGIFEAA
NGGTVFLDEIGEMSVAMQAKLLRAIQAKEIRRVGGKVNIPVDVRIISATNRDLEAEIRRGNFREDLFYRLNVIRISLPPL
RERGSDIAALTDFFVAKYRGDTGVKGLSRAALKLLMNYSWPGNVRQLESVIERGILMAEGELVEPGDLPAEIGEGVSPGG
GLPFELPADGIQFEELEKNLIIKAMERAGGVIAKAAPLLGMSYKTLQYRLEKFGITRDQGP

Sequences:

>Translated_461_residues
MQNGETMPATILIVDDERGQREILQTILEGERYETTTAAGGQEALALLDEREFDVILTDLKMQGMSGMELLERLLAADPQ
QCIIMMTAHGTVDSAVEAMKKGAFDYLEKPLERDTLLLTLRRAVERVRLLKENRALHKKLEETGAIPDIIGEHPKMKEVF
RIVTKIAPTASTVLIQGESGTGKELVASAIHERSPRADKPFFAINCAAIPETLMESELFGHEKGAFTGASSREIGIFEAA
NGGTVFLDEIGEMSVAMQAKLLRAIQAKEIRRVGGKVNIPVDVRIISATNRDLEAEIRRGNFREDLFYRLNVIRISLPPL
RERGSDIAALTDFFVAKYRGDTGVKGLSRAALKLLMNYSWPGNVRQLESVIERGILMAEGELVEPGDLPAEIGEGVSPGG
GLPFELPADGIQFEELEKNLIIKAMERAGGVIAKAAPLLGMSYKTLQYRLEKFGITRDQGP
>Mature_461_residues
MQNGETMPATILIVDDERGQREILQTILEGERYETTTAAGGQEALALLDEREFDVILTDLKMQGMSGMELLERLLAADPQ
QCIIMMTAHGTVDSAVEAMKKGAFDYLEKPLERDTLLLTLRRAVERVRLLKENRALHKKLEETGAIPDIIGEHPKMKEVF
RIVTKIAPTASTVLIQGESGTGKELVASAIHERSPRADKPFFAINCAAIPETLMESELFGHEKGAFTGASSREIGIFEAA
NGGTVFLDEIGEMSVAMQAKLLRAIQAKEIRRVGGKVNIPVDVRIISATNRDLEAEIRRGNFREDLFYRLNVIRISLPPL
RERGSDIAALTDFFVAKYRGDTGVKGLSRAALKLLMNYSWPGNVRQLESVIERGILMAEGELVEPGDLPAEIGEGVSPGG
GLPFELPADGIQFEELEKNLIIKAMERAGGVIAKAAPLLGMSYKTLQYRLEKFGITRDQGP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=44.6666666666667, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=44.1964285714286, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=42.3982869379015, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=40.2247191011236, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI87082117, Length=339, Percent_Identity=44.2477876106195, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=45, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789087, Length=336, Percent_Identity=43.1547619047619, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=53.448275862069, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1787583, Length=324, Percent_Identity=41.358024691358, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=327, Percent_Identity=41.5902140672783, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=41.4330218068536, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081858, Length=347, Percent_Identity=30.5475504322767, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1789828, Length=236, Percent_Identity=34.7457627118644, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50684; Mature: 50684

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNGETMPATILIVDDERGQREILQTILEGERYETTTAAGGQEALALLDEREFDVILTDL
CCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHCCCCCEEEEECH
KMQGMSGMELLERLLAADPQQCIIMMTAHGTVDSAVEAMKKGAFDYLEKPLERDTLLLTL
HHCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHCCHHHHHHHHHH
RRAVERVRLLKENRALHKKLEETGAIPDIIGEHPKMKEVFRIVTKIAPTASTVLIQGESG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCC
TGKELVASAIHERSPRADKPFFAINCAAIPETLMESELFGHEKGAFTGASSREIGIFEAA
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
NGGTVFLDEIGEMSVAMQAKLLRAIQAKEIRRVGGKVNIPVDVRIISATNRDLEAEIRRG
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHCC
NFREDLFYRLNVIRISLPPLRERGSDIAALTDFFVAKYRGDTGVKGLSRAALKLLMNYSW
CCHHHHHEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
PGNVRQLESVIERGILMAEGELVEPGDLPAEIGEGVSPGGGLPFELPADGIQFEELEKNL
CCCHHHHHHHHHCCEEEECCCEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
IIKAMERAGGVIAKAAPLLGMSYKTLQYRLEKFGITRDQGP
HHHHHHHHCCEEHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQNGETMPATILIVDDERGQREILQTILEGERYETTTAAGGQEALALLDEREFDVILTDL
CCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHCCCCCEEEEECH
KMQGMSGMELLERLLAADPQQCIIMMTAHGTVDSAVEAMKKGAFDYLEKPLERDTLLLTL
HHCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHCCHHHHHHHHHH
RRAVERVRLLKENRALHKKLEETGAIPDIIGEHPKMKEVFRIVTKIAPTASTVLIQGESG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCC
TGKELVASAIHERSPRADKPFFAINCAAIPETLMESELFGHEKGAFTGASSREIGIFEAA
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
NGGTVFLDEIGEMSVAMQAKLLRAIQAKEIRRVGGKVNIPVDVRIISATNRDLEAEIRRG
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHCC
NFREDLFYRLNVIRISLPPLRERGSDIAALTDFFVAKYRGDTGVKGLSRAALKLLMNYSW
CCHHHHHEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
PGNVRQLESVIERGILMAEGELVEPGDLPAEIGEGVSPGGGLPFELPADGIQFEELEKNL
CCCHHHHHHHHHCCEEEECCCEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
IIKAMERAGGVIAKAAPLLGMSYKTLQYRLEKFGITRDQGP
HHHHHHHHCCEEHHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]