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The map label for this gene is zraS [H]

Identifier: 39995392

GI number: 39995392

Start: 311626

End: 313428

Strand: Reverse

Name: zraS [H]

Synonym: GSU0283

Alternate gene names: 39995392

Gene position: 313428-311626 (Counterclockwise)

Preceding gene: 39995393

Following gene: 39995390

Centisome position: 8.22

GC content: 61.18

Gene sequence:

>1803_bases
ATGGCTGTTCACGATCCCTACACCATACTGAGCAGCGCCATTCGGATCGCCAACGCGACCGAGCGCTCCCATGATGAACG
GCTCAAGACCCTTGCCCTTCTCATTGCCGAGGCGTTCGGAGCCCTTTCCGCCACATTCTATCTTCTGGACGGCGACGGCC
GTGTTATCGTCCGCAAAATATCCAGCGCCTTCTCCGACATCTGCAGCAGAGACTGCCGTATTCCCGGCGGACGCGGCATT
GCCGGGCTGTGCGCCTCAAGCGGCAAGCCGATCCGGCAGGACTGCGCGGGATGCCATCCCGATGAAGTCGTAACGGGCAA
TGAACGAACCATCGCTGCCTTTCCAGTCAGCTGCCAGGGACAGTCTCTGGGGGTCCTCGCCCTGGGGTTCGCCCATGACG
CGCCCCTGACCGACGACGACCGGGACATGCTCGCCGTAGTCCTCATCGAAGCTGCCGGCGTAATGCGCTGCAAGCGTCAG
CTTGAATCGGTGGAAAAGCGTATCAGGGAACTCTCCTTCCTCAACCGCATCAATGGGGTCATGCTGTCGACCATTGAGCT
CAACCGGCTCATCCACCTGCTGCTGACAGCCCTCACGTCCGACCAGCCGCCACTGTTCGATCGGGCCATGCTCTTTCTGC
TCAATGAGCGCGCCGGCATTCTCCAGGGGATGATGGGCATCACGTCAGCACGGCAGACCGACAGCAACGCGCCGTCCGAG
CCAAGGACAAAGCGACGGTTCCCCGTCCGGAACGCCGACTTCGACTCCGTCGTCAAGGCCACCCGCCTCCCCCTTGATGC
GTCCCTCAACCAGATATCCCGGGCTGTTCTGGAGCGCACCCTGCTCCACGTGCAGCATCCCGACCAGGAACAGCCGGTTG
ACCGGACCCTCACGAAACAGTTCGGCACATCGTCCTATGCAGTCGCTCCCCTCGTGTCCCAAGACCGCGTTGTCGGCGCC
ATTGTCGTCGACAACCGTCTCACGGACCGCCCCCTGGCCGGCGACGATCTCGGCATCCTCCACCTGGTTTCCGGCCAGGC
CGGAATGGCCATCGAAAACTCGATCCTTTTCCATCGGCTCGAAGAAACGAACCGCAACCTTCAGGACGCCAAGGAGCGAC
TCCTTCAAGAGGAAAAACTGGCGGCCATCGGCCGGATGGCGGCCAGCATCGCTCACGAGATCAAGAATCCTCTCGTTTCA
GTGGGAGGCTTTGCCGGCAGGCTCAAAAGGAAATTCACCCCCGAGTCAGAGGAGTGGCTTTACGCCGATGTCATCGGGCG
CGAGGTGCAGCATCTGGAAAAAATGCTGAGTGACATCCTCTTTTTCTCGCGAAAAACCACCATCTGCTATACCCGCTGCG
GCATCAACCAGATCATCGAAGACGGGCTGGCAACCATGGCCGTCCCTCTGGAACAGAGGGAGATTGTCGTTGACAAGCGC
TTCGCCTCCCGCTTGCCGACCCTGCTGGGCGATTGCCAGCAGCTCCGTCACGTCTTCACCAACCTGATAAGCAACGCCCT
GGATGTCATGGAACCGCAGGGGGTTCTCACCATCGAAACCGGCCTGGCACGGATCGACGGCAAGCGGGCCGTATCCGTCA
AGGTGGGCGACACCGGCAGCGGCATCGCCCCCGATGTCCGTCACTCGATCTTCACCCCCTTCTTTACCACCAAGGAAAAA
GGGACCGGTCTCGGCCTCGCCATCGTGCACCGGATCATTACCAACCACGGCGGACGGATCGAAGTCGAAAACCGACCCGA
AGGAGGCGCCCTCTTCACGGTAGTTCTCCCCACGTCACCCTGA

Upstream 100 bases:

>100_bases
CCGTCACCACCCTCTGCATCGACTGCAAGATGGAGCAGGAAAGAAAAGAAAAACATCCCTGACCACTTCTCCCCCTCGCC
CCCTTCCCGCGGAGTCTTGG

Downstream 100 bases:

>100_bases
TTTTTTAGTTTTCAACTCCAACGGATTGGGTTATATACTATCGCTTCGCACACAATTCCTCCGGGGACGTAGCTCAGCTG
GGAGAGCGATGCGTTCGCAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MAVHDPYTILSSAIRIANATERSHDERLKTLALLIAEAFGALSATFYLLDGDGRVIVRKISSAFSDICSRDCRIPGGRGI
AGLCASSGKPIRQDCAGCHPDEVVTGNERTIAAFPVSCQGQSLGVLALGFAHDAPLTDDDRDMLAVVLIEAAGVMRCKRQ
LESVEKRIRELSFLNRINGVMLSTIELNRLIHLLLTALTSDQPPLFDRAMLFLLNERAGILQGMMGITSARQTDSNAPSE
PRTKRRFPVRNADFDSVVKATRLPLDASLNQISRAVLERTLLHVQHPDQEQPVDRTLTKQFGTSSYAVAPLVSQDRVVGA
IVVDNRLTDRPLAGDDLGILHLVSGQAGMAIENSILFHRLEETNRNLQDAKERLLQEEKLAAIGRMAASIAHEIKNPLVS
VGGFAGRLKRKFTPESEEWLYADVIGREVQHLEKMLSDILFFSRKTTICYTRCGINQIIEDGLATMAVPLEQREIVVDKR
FASRLPTLLGDCQQLRHVFTNLISNALDVMEPQGVLTIETGLARIDGKRAVSVKVGDTGSGIAPDVRHSIFTPFFTTKEK
GTGLGLAIVHRIITNHGGRIEVENRPEGGALFTVVLPTSP

Sequences:

>Translated_600_residues
MAVHDPYTILSSAIRIANATERSHDERLKTLALLIAEAFGALSATFYLLDGDGRVIVRKISSAFSDICSRDCRIPGGRGI
AGLCASSGKPIRQDCAGCHPDEVVTGNERTIAAFPVSCQGQSLGVLALGFAHDAPLTDDDRDMLAVVLIEAAGVMRCKRQ
LESVEKRIRELSFLNRINGVMLSTIELNRLIHLLLTALTSDQPPLFDRAMLFLLNERAGILQGMMGITSARQTDSNAPSE
PRTKRRFPVRNADFDSVVKATRLPLDASLNQISRAVLERTLLHVQHPDQEQPVDRTLTKQFGTSSYAVAPLVSQDRVVGA
IVVDNRLTDRPLAGDDLGILHLVSGQAGMAIENSILFHRLEETNRNLQDAKERLLQEEKLAAIGRMAASIAHEIKNPLVS
VGGFAGRLKRKFTPESEEWLYADVIGREVQHLEKMLSDILFFSRKTTICYTRCGINQIIEDGLATMAVPLEQREIVVDKR
FASRLPTLLGDCQQLRHVFTNLISNALDVMEPQGVLTIETGLARIDGKRAVSVKVGDTGSGIAPDVRHSIFTPFFTTKEK
GTGLGLAIVHRIITNHGGRIEVENRPEGGALFTVVLPTSP
>Mature_599_residues
AVHDPYTILSSAIRIANATERSHDERLKTLALLIAEAFGALSATFYLLDGDGRVIVRKISSAFSDICSRDCRIPGGRGIA
GLCASSGKPIRQDCAGCHPDEVVTGNERTIAAFPVSCQGQSLGVLALGFAHDAPLTDDDRDMLAVVLIEAAGVMRCKRQL
ESVEKRIRELSFLNRINGVMLSTIELNRLIHLLLTALTSDQPPLFDRAMLFLLNERAGILQGMMGITSARQTDSNAPSEP
RTKRRFPVRNADFDSVVKATRLPLDASLNQISRAVLERTLLHVQHPDQEQPVDRTLTKQFGTSSYAVAPLVSQDRVVGAI
VVDNRLTDRPLAGDDLGILHLVSGQAGMAIENSILFHRLEETNRNLQDAKERLLQEEKLAAIGRMAASIAHEIKNPLVSV
GGFAGRLKRKFTPESEEWLYADVIGREVQHLEKMLSDILFFSRKTTICYTRCGINQIIEDGLATMAVPLEQREIVVDKRF
ASRLPTLLGDCQQLRHVFTNLISNALDVMEPQGVLTIETGLARIDGKRAVSVKVGDTGSGIAPDVRHSIFTPFFTTKEKG
TGLGLAIVHRIITNHGGRIEVENRPEGGALFTVVLPTSP

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=33.8775510204082, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=32.4786324786325, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=31.304347826087, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790300, Length=339, Percent_Identity=29.2035398230088, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=31.4655172413793, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081816, Length=220, Percent_Identity=31.3636363636364, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=25, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=27.6, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=27.1929824561404, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=333, Percent_Identity=25.5255255255255, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=112, Percent_Identity=33.9285714285714, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=28.8, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65677; Mature: 65545

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVHDPYTILSSAIRIANATERSHDERLKTLALLIAEAFGALSATFYLLDGDGRVIVRKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHH
SSAFSDICSRDCRIPGGRGIAGLCASSGKPIRQDCAGCHPDEVVTGNERTIAAFPVSCQG
HHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHCCCCCCCEECCCCCEEEEEECCCCC
QSLGVLALGFAHDAPLTDDDRDMLAVVLIEAAGVMRCKRQLESVEKRIRELSFLNRINGV
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MLSTIELNRLIHLLLTALTSDQPPLFDRAMLFLLNERAGILQGMMGITSARQTDSNAPSE
EEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PRTKRRFPVRNADFDSVVKATRLPLDASLNQISRAVLERTLLHVQHPDQEQPVDRTLTKQ
CCHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FGTSSYAVAPLVSQDRVVGAIVVDNRLTDRPLAGDDLGILHLVSGQAGMAIENSILFHRL
CCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHH
EETNRNLQDAKERLLQEEKLAAIGRMAASIAHEIKNPLVSVGGFAGRLKRKFTPESEEWL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEE
YADVIGREVQHLEKMLSDILFFSRKTTICYTRCGINQIIEDGLATMAVPLEQREIVVDKR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCHHHEECCCCHHHHHHHHH
FASRLPTLLGDCQQLRHVFTNLISNALDVMEPQGVLTIETGLARIDGKRAVSVKVGDTGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCEEEEEEECCCCC
GIAPDVRHSIFTPFFTTKEKGTGLGLAIVHRIITNHGGRIEVENRPEGGALFTVVLPTSP
CCCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
AVHDPYTILSSAIRIANATERSHDERLKTLALLIAEAFGALSATFYLLDGDGRVIVRKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHH
SSAFSDICSRDCRIPGGRGIAGLCASSGKPIRQDCAGCHPDEVVTGNERTIAAFPVSCQG
HHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHCCCCCCCEECCCCCEEEEEECCCCC
QSLGVLALGFAHDAPLTDDDRDMLAVVLIEAAGVMRCKRQLESVEKRIRELSFLNRINGV
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MLSTIELNRLIHLLLTALTSDQPPLFDRAMLFLLNERAGILQGMMGITSARQTDSNAPSE
EEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PRTKRRFPVRNADFDSVVKATRLPLDASLNQISRAVLERTLLHVQHPDQEQPVDRTLTKQ
CCHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FGTSSYAVAPLVSQDRVVGAIVVDNRLTDRPLAGDDLGILHLVSGQAGMAIENSILFHRL
CCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHH
EETNRNLQDAKERLLQEEKLAAIGRMAASIAHEIKNPLVSVGGFAGRLKRKFTPESEEWL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEE
YADVIGREVQHLEKMLSDILFFSRKTTICYTRCGINQIIEDGLATMAVPLEQREIVVDKR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCHHHEECCCCHHHHHHHHH
FASRLPTLLGDCQQLRHVFTNLISNALDVMEPQGVLTIETGLARIDGKRAVSVKVGDTGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCEEEEEEECCCCC
GIAPDVRHSIFTPFFTTKEKGTGLGLAIVHRIITNHGGRIEVENRPEGGALFTVVLPTSP
CCCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]