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The map label for this gene is mutY [H]

Identifier: 38234544

GI number: 38234544

Start: 2027764

End: 2028651

Strand: Direct

Name: mutY [H]

Synonym: DIP1980

Alternate gene names: 38234544

Gene position: 2027764-2028651 (Clockwise)

Preceding gene: 38234541

Following gene: 38234549

Centisome position: 81.48

GC content: 59.12

Gene sequence:

>888_bases
ATGAACGCTAATAATGTAGAAAATATCCCGCAGATTTTGACCGAGTGGTATCGCAAAAACGCTCGTAGCATAGTGTGGCG
TACCCCACAGACTTCCGCGTGGGGCGTGTTGCTCAGCGAGGTTATGAGCCAGCAAACTCCGGTGGCCCGAGTTGAGCCGA
TATGGGTCGATTGGATGCGACGCTGGCCTACCCCCGCTGACTTCGCTCAAGCGGGCAAAGATGAGGTGTTGCGTGCGTGG
GATCGGCTCGGTTACCCGCGTCGTGCGCTTCGTCTTCACGAGTGCGCGCAGCAGATTGTACAGCGTCATGGTGGTGAGGT
CCCCCACGATGTGGAGCAATTGTTGGCGCTGCCAGGTATTGGCGATTACACCGCCCGCGCGGTGGCGGCTTTTGCTTTCG
GGCAGCGGGTTGCCGTGGTTGATACGAATGTGCGCCGAGTACATCACCGCGTGTATCAGGGGATTTACCTTGCGGGAAAT
GCGTCGAAACGCGAGCTGCGCGAGGTGGAGGCCTTGTTGCCGCATGACAACGCGCCGGAGTTTTCGGTGGCGTTGATGGA
GCTCGGCGCTTTGGTGTGCCAAACGTCCCCGCAGTGTGATCGTTGCCCGCTGACGCAGCAGTGTCGATGGATCGCGTTGG
GCCGTCCGATGCCGAGTGCGGAGGAAACCGCCAAGGCGAAAAAGCGGGTTCAGAAATTTGTGGGCACTGATCGTCAGGTT
CGCGGTTTGATTATGGCGGTGTTAAGAAATGCGGAGGCACCGGTCCCACAGTCAGCTATCGACGTCGTGTGGCCCGATGC
TGCCCAGCGTTCACGGGCGCTGTTCAGTTTGCTTGACGACGGCCTGGCGACCCAAAACGAGGCGGGACTTTTTAGTTTGC
CCACCTAG

Upstream 100 bases:

>100_bases
ATGCTTGTTTTTTATCCAATTGTCATACAACGTGGGGGGTTTCGGATTGCATGCTGTGCCCAGTTACACTGAAGCCTTGC
ACCCACACAGATGAGCTTTT

Downstream 100 bases:

>100_bases
GCTAGTGGTTTATCAAATTCGATGAGGTGGCCAAAGGTCCATGCGCGATCGGTGAGCAATCGTGCCAGTACGAGGCCTGC
GCTGATAGAAAACACCACCA

Product: putative DNA repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNANNVENIPQILTEWYRKNARSIVWRTPQTSAWGVLLSEVMSQQTPVARVEPIWVDWMRRWPTPADFAQAGKDEVLRAW
DRLGYPRRALRLHECAQQIVQRHGGEVPHDVEQLLALPGIGDYTARAVAAFAFGQRVAVVDTNVRRVHHRVYQGIYLAGN
ASKRELREVEALLPHDNAPEFSVALMELGALVCQTSPQCDRCPLTQQCRWIALGRPMPSAEETAKAKKRVQKFVGTDRQV
RGLIMAVLRNAEAPVPQSAIDVVWPDAAQRSRALFSLLDDGLATQNEAGLFSLPT

Sequences:

>Translated_295_residues
MNANNVENIPQILTEWYRKNARSIVWRTPQTSAWGVLLSEVMSQQTPVARVEPIWVDWMRRWPTPADFAQAGKDEVLRAW
DRLGYPRRALRLHECAQQIVQRHGGEVPHDVEQLLALPGIGDYTARAVAAFAFGQRVAVVDTNVRRVHHRVYQGIYLAGN
ASKRELREVEALLPHDNAPEFSVALMELGALVCQTSPQCDRCPLTQQCRWIALGRPMPSAEETAKAKKRVQKFVGTDRQV
RGLIMAVLRNAEAPVPQSAIDVVWPDAAQRSRALFSLLDDGLATQNEAGLFSLPT
>Mature_295_residues
MNANNVENIPQILTEWYRKNARSIVWRTPQTSAWGVLLSEVMSQQTPVARVEPIWVDWMRRWPTPADFAQAGKDEVLRAW
DRLGYPRRALRLHECAQQIVQRHGGEVPHDVEQLLALPGIGDYTARAVAAFAFGQRVAVVDTNVRRVHHRVYQGIYLAGN
ASKRELREVEALLPHDNAPEFSVALMELGALVCQTSPQCDRCPLTQQCRWIALGRPMPSAEETAKAKKRVQKFVGTDRQV
RGLIMAVLRNAEAPVPQSAIDVVWPDAAQRSRALFSLLDDGLATQNEAGLFSLPT

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=208, Percent_Identity=40.3846153846154, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI115298654, Length=208, Percent_Identity=40.3846153846154, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI115298652, Length=208, Percent_Identity=40.3846153846154, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI190358497, Length=208, Percent_Identity=40.3846153846154, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI115298650, Length=208, Percent_Identity=40.3846153846154, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI115298648, Length=208, Percent_Identity=40.3846153846154, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1789331, Length=201, Percent_Identity=39.8009950248756, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 33085; Mature: 33085

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANNVENIPQILTEWYRKNARSIVWRTPQTSAWGVLLSEVMSQQTPVARVEPIWVDWMR
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHH
RWPTPADFAQAGKDEVLRAWDRLGYPRRALRLHECAQQIVQRHGGEVPHDVEQLLALPGI
HCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
GDYTARAVAAFAFGQRVAVVDTNVRRVHHRVYQGIYLAGNASKRELREVEALLPHDNAPE
CHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCCCCH
FSVALMELGALVCQTSPQCDRCPLTQQCRWIALGRPMPSAEETAKAKKRVQKFVGTDRQV
HHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHH
RGLIMAVLRNAEAPVPQSAIDVVWPDAAQRSRALFSLLDDGLATQNEAGLFSLPT
HHHHHHHHHCCCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCEECCC
>Mature Secondary Structure
MNANNVENIPQILTEWYRKNARSIVWRTPQTSAWGVLLSEVMSQQTPVARVEPIWVDWMR
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHH
RWPTPADFAQAGKDEVLRAWDRLGYPRRALRLHECAQQIVQRHGGEVPHDVEQLLALPGI
HCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
GDYTARAVAAFAFGQRVAVVDTNVRRVHHRVYQGIYLAGNASKRELREVEALLPHDNAPE
CHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCCCCH
FSVALMELGALVCQTSPQCDRCPLTQQCRWIALGRPMPSAEETAKAKKRVQKFVGTDRQV
HHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHH
RGLIMAVLRNAEAPVPQSAIDVVWPDAAQRSRALFSLLDDGLATQNEAGLFSLPT
HHHHHHHHHCCCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]