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The map label for this gene is aecD [C]

Identifier: 38234307

GI number: 38234307

Start: 1778334

End: 1779464

Strand: Direct

Name: aecD [C]

Synonym: DIP1736

Alternate gene names: 38234307

Gene position: 1778334-1779464 (Clockwise)

Preceding gene: 38234306

Following gene: 38234308

Centisome position: 71.46

GC content: 50.75

Gene sequence:

>1131_bases
ATGCAATTCCCATCAATTGAAGATCTCCGCGCTCGCAACACCATGAAATGGACACGGTATGGACAAGGTGTCCTACCACT
GTGGGTAGCAGAATCCGATTTTTCTACTTGTCCCGCCGTACTCCAAGCCATAACTGACGCAGTTCAAAGAGAAGCCTTCG
GATATCAACCCGATGGCTCCCTACTTTCGCAAGCAACCGCAGAATTCTATGCAGATCGCTACGGCTACCAAGCACGCCCC
GAATGGATATTTCCCATCCCTGACGTCGTACGCGGACTCTATATAGCGATCGATCATTTCACTCCTGCACAATCCAAGGT
GATAGTTCCGACCCCCGCCTATCCGCCATTTTTTCATCTACTCTCTGCGACCCAACGCGAAGGCATATTTATCGATGCCA
CTGGAGGCATCAACCTACACGACGTAGAAAAAGGTTTCCAAGCTGGTGCACGTTCCATTCTGCTGTGCAACCCATATAAC
CCACTCGGAATGGTTTTCGCCCCTGAATGGCTCAACGAACTCTGCGACCTTGCACACCGCTACGATGCTCGCGTACTTGT
AGACGAAATCCACGCACCCTTAGTTTTCGACGGGCAGCACACCGTCGCCGCGGGAGTATCCGACACAGCAGCGTCCGTGT
GCATTACGATTACGGCACCATCCAAAGCATGGAACATTGCCGGCCTCAAATGTGCCCAAATCATCTTCAGTAACCCCTCC
GATGCTGAGCATTGGCAGCAACTCAGTCCAGTGATTAAAGATGGTGCTTCTACGCTCGGCCTCATCGCAGCAGAAGCCGC
ATACCGATACGGCACAGATTTTCTTAATCAAGAAGTGGCCTATCTCAAGAACAACCATGATTTCTTGCTCCATGAGATTC
CGAAAAGAATCCCAGGGGCCAAGATCACCCCAATGCAAGCTACCTACTTGATGTGGATCGACTTCAGAGATACCACCATT
GAAGGATCACCATCAGAATTCTTTATTGAAAAAGCCAAGGTAGCAATGAATGATGGTGCATGGTTCGGCGAAGATGGCAC
AGGGTTTTGTCGCCTCAACTTTGCCACCTCCCGAGAGGTTCTAGAAGAGGCAATCGACCGCATGGCAAAGGCCGTGTCCC
ATCACACATAA

Upstream 100 bases:

>100_bases
TTACGCGGAACTCCTTAAACTGACTGCCAACGCCTCCGATGACAGTAAAGAACAACTCAAACGCTTTGGGTTCCATTCAT
GAGCGAAGAAAGGCTAACCG

Downstream 100 bases:

>100_bases
CCCCCGAATCTCACCTTATGGGAACTTAGTGTTATATTGTGGGAAAGCTTTAACCCGTATTTGAAAGTTTGTGAATAACC
ATGGCCTCTCCCACCTCTGA

Product: beta C-S lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MQFPSIEDLRARNTMKWTRYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFGYQPDGSLLSQATAEFYADRYGYQARP
EWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHLLSATQREGIFIDATGGINLHDVEKGFQAGARSILLCNPYN
PLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSNPS
DAEHWQQLSPVIKDGASTLGLIAAEAAYRYGTDFLNQEVAYLKNNHDFLLHEIPKRIPGAKITPMQATYLMWIDFRDTTI
EGSPSEFFIEKAKVAMNDGAWFGEDGTGFCRLNFATSREVLEEAIDRMAKAVSHHT

Sequences:

>Translated_376_residues
MQFPSIEDLRARNTMKWTRYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFGYQPDGSLLSQATAEFYADRYGYQARP
EWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHLLSATQREGIFIDATGGINLHDVEKGFQAGARSILLCNPYN
PLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSNPS
DAEHWQQLSPVIKDGASTLGLIAAEAAYRYGTDFLNQEVAYLKNNHDFLLHEIPKRIPGAKITPMQATYLMWIDFRDTTI
EGSPSEFFIEKAKVAMNDGAWFGEDGTGFCRLNFATSREVLEEAIDRMAKAVSHHT
>Mature_376_residues
MQFPSIEDLRARNTMKWTRYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFGYQPDGSLLSQATAEFYADRYGYQARP
EWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHLLSATQREGIFIDATGGINLHDVEKGFQAGARSILLCNPYN
PLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSNPS
DAEHWQQLSPVIKDGASTLGLIAAEAAYRYGTDFLNQEVAYLKNNHDFLLHEIPKRIPGAKITPMQATYLMWIDFRDTTI
EGSPSEFFIEKAKVAMNDGAWFGEDGTGFCRLNFATSREVLEEAIDRMAKAVSHHT

Specific function: Acts As A Beta-Cystathionase And As A Repressor Of The Maltose Regulon. [C]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=374, Percent_Identity=28.3422459893048, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788722, Length=382, Percent_Identity=22.2513089005236, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41723; Mature: 41723

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFPSIEDLRARNTMKWTRYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFGYQPDGS
CCCCCCHHHHHCCCEEHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHH
LLSQATAEFYADRYGYQARPEWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHL
HHHHHHHHHHHHHCCCCCCCCEECCCHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHH
LSATQREGIFIDATGGINLHDVEKGFQAGARSILLCNPYNPLGMVFAPEWLNELCDLAHR
HHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEECHHHHHHHHHHHHH
YDARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSNPS
CCCCEEEHHCCCCEEECCCCEEECCCCCCCCEEEEEEECCCCCCCCCCHHEEHEEECCCC
DAEHWQQLSPVIKDGASTLGLIAAEAAYRYGTDFLNQEVAYLKNNHDFLLHEIPKRIPGA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCHHHHHCCCCCHHHHHHHHHCCCC
KITPMQATYLMWIDFRDTTIEGSPSEFFIEKAKVAMNDGAWFGEDGTGFCRLNFATSREV
CCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHEEECCCCEECCCCCEEEEEECHHHHHH
LEEAIDRMAKAVSHHT
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFPSIEDLRARNTMKWTRYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFGYQPDGS
CCCCCCHHHHHCCCEEHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHH
LLSQATAEFYADRYGYQARPEWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHL
HHHHHHHHHHHHHCCCCCCCCEECCCHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHH
LSATQREGIFIDATGGINLHDVEKGFQAGARSILLCNPYNPLGMVFAPEWLNELCDLAHR
HHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEECHHHHHHHHHHHHH
YDARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSNPS
CCCCEEEHHCCCCEEECCCCEEECCCCCCCCEEEEEEECCCCCCCCCCHHEEHEEECCCC
DAEHWQQLSPVIKDGASTLGLIAAEAAYRYGTDFLNQEVAYLKNNHDFLLHEIPKRIPGA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCHHHHHCCCCCHHHHHHHHHCCCC
KITPMQATYLMWIDFRDTTIEGSPSEFFIEKAKVAMNDGAWFGEDGTGFCRLNFATSREV
CCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHEEECCCCEECCCCCEEEEEECHHHHHH
LEEAIDRMAKAVSHHT
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]