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The map label for this gene is ptpA [H]

Identifier: 38234254

GI number: 38234254

Start: 1720169

End: 1720630

Strand: Direct

Name: ptpA [H]

Synonym: DIP1683

Alternate gene names: 38234254

Gene position: 1720169-1720630 (Clockwise)

Preceding gene: 38234253

Following gene: 38234255

Centisome position: 69.12

GC content: 53.9

Gene sequence:

>462_bases
GTGATCACTTTTGTATGCACCGGCAATATTTGCCGTTCTCCGATGGCCGAGGTGATCTGCACGAGCGTTTTAGAAGACGA
GGGGTTAAGCCACGCTATTCGTGCTAACTCCTGCGGTACTGGTGGGTGGCATGTGGGCCAAGGGGCTGATTCTCGAGCAA
TCGCCGAACTGCGCGCCTCGGGTTACGATGGCACCCATCACCGCGCAAGCCAACTCGGTGAACAACATAGGAGTTCCGAC
CTGCTTATTGCGTTGGATTCTTCTCATCGCAATGCGCTTTTGCGAATGGGCTATCCAGCAGAAAAGGTGCGATTATTGCA
GTCTTTTAATCCGGATTCTCATACTCCAGATGTTGCGGATCCTTACTATGGCACCGCCGCTGATTTTAAAACCACCCGCC
GTGACATCGAGGCAGCTATGCCAGGTCTGATGGCCTGGCTTCGGGAGGCCATTCATGCCTAG

Upstream 100 bases:

>100_bases
CAAGAGTGGTCCCACGCGGATTATCATGCACGTAATATGGCGGAGGCGAAAGGAATCGTACGTGACTTCTTCAACTAATA
ACTCCAGTAATCCAGCTTTT

Downstream 100 bases:

>100_bases
GACGCACACAACTGTCACCGGCTGGAAGGTGTTTCTTACCCCTGGGTGGGTTCTCACCGCGGTACTTGCTATTGCTTTTT
CTTACTTTGCTATCACGGTG

Product: low molecular weight protein-tyrosine-phosphatase

Products: NA

Alternate protein names: PTPase [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MITFVCTGNICRSPMAEVICTSVLEDEGLSHAIRANSCGTGGWHVGQGADSRAIAELRASGYDGTHHRASQLGEQHRSSD
LLIALDSSHRNALLRMGYPAEKVRLLQSFNPDSHTPDVADPYYGTAADFKTTRRDIEAAMPGLMAWLREAIHA

Sequences:

>Translated_153_residues
MITFVCTGNICRSPMAEVICTSVLEDEGLSHAIRANSCGTGGWHVGQGADSRAIAELRASGYDGTHHRASQLGEQHRSSD
LLIALDSSHRNALLRMGYPAEKVRLLQSFNPDSHTPDVADPYYGTAADFKTTRRDIEAAMPGLMAWLREAIHA
>Mature_153_residues
MITFVCTGNICRSPMAEVICTSVLEDEGLSHAIRANSCGTGGWHVGQGADSRAIAELRASGYDGTHHRASQLGEQHRSSD
LLIALDSSHRNALLRMGYPAEKVRLLQSFNPDSHTPDVADPYYGTAADFKTTRRDIEAAMPGLMAWLREAIHA

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=136, Percent_Identity=34.5588235294118, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI4757714, Length=135, Percent_Identity=31.1111111111111, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325330, Length=141, Percent_Identity=30.4964539007092, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI78706766, Length=147, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI78706768, Length=147, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI78706764, Length=125, Percent_Identity=35.2, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16622; Mature: 16622

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITFVCTGNICRSPMAEVICTSVLEDEGLSHAIRANSCGTGGWHVGQGADSRAIAELRAS
CEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHC
GYDGTHHRASQLGEQHRSSDLLIALDSSHRNALLRMGYPAEKVRLLQSFNPDSHTPDVAD
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCC
PYYGTAADFKTTRRDIEAAMPGLMAWLREAIHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITFVCTGNICRSPMAEVICTSVLEDEGLSHAIRANSCGTGGWHVGQGADSRAIAELRAS
CEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHC
GYDGTHHRASQLGEQHRSSDLLIALDSSHRNALLRMGYPAEKVRLLQSFNPDSHTPDVAD
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCC
PYYGTAADFKTTRRDIEAAMPGLMAWLREAIHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]