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The map label for this gene is polC [H]

Identifier: 38234148

GI number: 38234148

Start: 1600226

End: 1601572

Strand: Direct

Name: polC [H]

Synonym: DIP1573

Alternate gene names: 38234148

Gene position: 1600226-1601572 (Clockwise)

Preceding gene: 38234147

Following gene: 38234149

Centisome position: 64.3

GC content: 51.97

Gene sequence:

>1347_bases
ATGTCCGGCCTCATCCCAGCACACGGTTTAAGCTTCCGCGTTGATGCCTCGACGCTTACAGGTCAGTCGTCGCTACTGCG
TGCAAGCCTAGGGCTTGACGACGTCCACCTGCAGGTTTCCGCCATCACAGAAGTAAAATCGGTGTTTGTAGCTGACGCCT
TTGACCGCGGACTAGTTACTGTCACTGCCGACAAAGAAATTGCTATTTGGTTCCCGCCTAATAGTGCAACCGAACAAGAA
CTTTTTGTTCGTACACTGTCAGCAGCAATGAATGGCGATGGCCCTATTCCCCAACCCGTGCCCCACTTAGATTTTGTGGC
GGTCGATGTAGAAACAACTAATAGCGACTGGGGTTCTATTTGTCAGATCGGTGCGGCTAAAGTACGAGATGGTCACGTTG
TAGAAACCAAAGAGTGGCTATGCACCCCACCAGGCGATTTGAATTCCTTCGACGAAGCTAACATCGCCATTCACGGCATT
ACCGCAGATATGGTCGCAACTGCGCCTAGCTTCGCTGAATGCTACGACCAATTTGCTGACTTCGCAGGAGATCTTCCGCT
GGCTGCACACAACGCACAATTTGATATGACTGCTTTCCTGCGTGCTACCCAAGCTGCTGACATCCGCCTGCGCACCACCA
ATTTTGGTTGTTCTCTCGCTGCCGCGCGCGCAGCACACCTACCTATTGCGAATCATAAACTTCCCACTGTCTCACAACAT
CTTCATGTTGAGCTTCGAAATCACCATAACGCTTGTGCGGATGCCGAAGCCTGTGCCGGAATTCTCATCGCTCTTACGCA
ACGTCTGAACACCGAAATCACTGATTTTACCTCCGCATTTAACATGCTAGGGTTCCACACTGGTCAATTATCCGACGCTC
GTGTGTATCCAGTTCTCAAAGTTCGTGGTGCCTCGAGCACTCCAGCTTCACCTGATTCCGCTGCCCCTGCTATTCAAACC
CCACCAGCAGAAAAACCCCGCAAAGCAACCAAAGCAGCGCGGGCACCGTGGTCGAAGGTGGCAACTCCAGAAACAATCCC
TGACCCTAATCCTGATGCCGATCCTCAGGGCCGGCTCTTTGGGCAATCTGTCACGCTTAGCGGCGATTTCGCCCCCTACG
ACAAAGGCGAGCTGTGGGCTGGAATTGCGAACCAAGGAGGCATTATTGGCAAAAACGTCACGAAAAAGACAACCATCCTT
GTATGCGGCCCATGGGACAAACCGACTTCTAAACAAAAACGTGCCGAAGAACTGCGCGCCAAAGGCCAAGAGATTGACCT
ATGGACTCAAGAAGACCTGTTTGCGCAACTAGGTCTTAATCCCGAGGACGAACAACCACCGTTTTAA

Upstream 100 bases:

>100_bases
GATGACACGTTCGAGCGCCGCAGTGAGCATGTCACTGCGCACCTGTAGTGTCAGACATCTGAGCAAGCACAAACCATAGG
AATTCAAGGAGCACAGCACT

Downstream 100 bases:

>100_bases
TATCCCACACAGAGGCCACAAAGGGGCCACACAAAGGGGGTAAAAGATAAATCTTTGGGAACCAACCCCCGTGCTCGTTA
CGTCTGAATATGTAGAACCT

Product: putative DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSGLIPAHGLSFRVDASTLTGQSSLLRASLGLDDVHLQVSAITEVKSVFVADAFDRGLVTVTADKEIAIWFPPNSATEQE
LFVRTLSAAMNGDGPIPQPVPHLDFVAVDVETTNSDWGSICQIGAAKVRDGHVVETKEWLCTPPGDLNSFDEANIAIHGI
TADMVATAPSFAECYDQFADFAGDLPLAAHNAQFDMTAFLRATQAADIRLRTTNFGCSLAAARAAHLPIANHKLPTVSQH
LHVELRNHHNACADAEACAGILIALTQRLNTEITDFTSAFNMLGFHTGQLSDARVYPVLKVRGASSTPASPDSAAPAIQT
PPAEKPRKATKAARAPWSKVATPETIPDPNPDADPQGRLFGQSVTLSGDFAPYDKGELWAGIANQGGIIGKNVTKKTTIL
VCGPWDKPTSKQKRAEELRAKGQEIDLWTQEDLFAQLGLNPEDEQPPF

Sequences:

>Translated_448_residues
MSGLIPAHGLSFRVDASTLTGQSSLLRASLGLDDVHLQVSAITEVKSVFVADAFDRGLVTVTADKEIAIWFPPNSATEQE
LFVRTLSAAMNGDGPIPQPVPHLDFVAVDVETTNSDWGSICQIGAAKVRDGHVVETKEWLCTPPGDLNSFDEANIAIHGI
TADMVATAPSFAECYDQFADFAGDLPLAAHNAQFDMTAFLRATQAADIRLRTTNFGCSLAAARAAHLPIANHKLPTVSQH
LHVELRNHHNACADAEACAGILIALTQRLNTEITDFTSAFNMLGFHTGQLSDARVYPVLKVRGASSTPASPDSAAPAIQT
PPAEKPRKATKAARAPWSKVATPETIPDPNPDADPQGRLFGQSVTLSGDFAPYDKGELWAGIANQGGIIGKNVTKKTTIL
VCGPWDKPTSKQKRAEELRAKGQEIDLWTQEDLFAQLGLNPEDEQPPF
>Mature_447_residues
SGLIPAHGLSFRVDASTLTGQSSLLRASLGLDDVHLQVSAITEVKSVFVADAFDRGLVTVTADKEIAIWFPPNSATEQEL
FVRTLSAAMNGDGPIPQPVPHLDFVAVDVETTNSDWGSICQIGAAKVRDGHVVETKEWLCTPPGDLNSFDEANIAIHGIT
ADMVATAPSFAECYDQFADFAGDLPLAAHNAQFDMTAFLRATQAADIRLRTTNFGCSLAAARAAHLPIANHKLPTVSQHL
HVELRNHHNACADAEACAGILIALTQRLNTEITDFTSAFNMLGFHTGQLSDARVYPVLKVRGASSTPASPDSAAPAIQTP
PAEKPRKATKAARAPWSKVATPETIPDPNPDADPQGRLFGQSVTLSGDFAPYDKGELWAGIANQGGIIGKNVTKKTTILV
CGPWDKPTSKQKRAEELRAKGQEIDLWTQEDLFAQLGLNPEDEQPPF

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 47983; Mature: 47852

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLIPAHGLSFRVDASTLTGQSSLLRASLGLDDVHLQVSAITEVKSVFVADAFDRGLVT
CCCCCCCCCCEEEEECHHHCCCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCEEE
VTADKEIAIWFPPNSATEQELFVRTLSAAMNGDGPIPQPVPHLDFVAVDVETTNSDWGSI
EEECCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCHHHH
CQIGAAKVRDGHVVETKEWLCTPPGDLNSFDEANIAIHGITADMVATAPSFAECYDQFAD
HHHCCCCCCCCCEEECCCEEECCCCCCCCCCCCCEEEEEEEHHHHHCCCCHHHHHHHHHH
FAGDLPLAAHNAQFDMTAFLRATQAADIRLRTTNFGCSLAAARAAHLPIANHKLPTVSQH
HCCCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHH
LHVELRNHHNACADAEACAGILIALTQRLNTEITDFTSAFNMLGFHTGQLSDARVYPVLK
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
VRGASSTPASPDSAAPAIQTPPAEKPRKATKAARAPWSKVATPETIPDPNPDADPQGRLF
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCEE
GQSVTLSGDFAPYDKGELWAGIANQGGIIGKNVTKKTTILVCGPWDKPTSKQKRAEELRA
CCEEEECCCCCCCCCCCEEEEECCCCCEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHH
KGQEIDLWTQEDLFAQLGLNPEDEQPPF
CCCEEEEECHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SGLIPAHGLSFRVDASTLTGQSSLLRASLGLDDVHLQVSAITEVKSVFVADAFDRGLVT
CCCCCCCCCEEEEECHHHCCCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCEEE
VTADKEIAIWFPPNSATEQELFVRTLSAAMNGDGPIPQPVPHLDFVAVDVETTNSDWGSI
EEECCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCHHHH
CQIGAAKVRDGHVVETKEWLCTPPGDLNSFDEANIAIHGITADMVATAPSFAECYDQFAD
HHHCCCCCCCCCEEECCCEEECCCCCCCCCCCCCEEEEEEEHHHHHCCCCHHHHHHHHHH
FAGDLPLAAHNAQFDMTAFLRATQAADIRLRTTNFGCSLAAARAAHLPIANHKLPTVSQH
HCCCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHH
LHVELRNHHNACADAEACAGILIALTQRLNTEITDFTSAFNMLGFHTGQLSDARVYPVLK
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
VRGASSTPASPDSAAPAIQTPPAEKPRKATKAARAPWSKVATPETIPDPNPDADPQGRLF
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCEE
GQSVTLSGDFAPYDKGELWAGIANQGGIIGKNVTKKTTILVCGPWDKPTSKQKRAEELRA
CCEEEECCCCCCCCCCCEEEEECCCCCEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHH
KGQEIDLWTQEDLFAQLGLNPEDEQPPF
CCCEEEEECHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]