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The map label for this gene is tetR [H]

Identifier: 38234146

GI number: 38234146

Start: 1597317

End: 1597862

Strand: Direct

Name: tetR [H]

Synonym: DIP1571

Alternate gene names: 38234146

Gene position: 1597317-1597862 (Clockwise)

Preceding gene: 38234144

Following gene: 38234147

Centisome position: 64.18

GC content: 48.17

Gene sequence:

>546_bases
GTGCAATTAAGTAAAGAGTCCATCATTTCTGCAAGCCTCGATATTTTGGATTCCTATGGTCTAGCCGACATGACAATGCG
AAGGCTTGCAACTCACCTAGGCGTTGCCCCTGGAGCTTTGTACTGGCATTTTAAAAACAAACAGGCATTAATTGATGCCA
TTGCTCGCCACATCATGGCACCGCTTATCGACGCCTCCCCTTCGGCTTATCATCATGACATCCCTTCGTTAGCATTCGAC
GTTCGATCCTTGATGTTGCGTCACCGAGATGGGGCCGAGCTTTTGAGTGCCGCACTGACAGATGCGTCGTTACGCAACGA
TATTATTAGCGTCGTTTCGGCCATTCTCGGCGGCTGCGACAAAGCCTACGTCGGCGCATCAACATTGCTGAATTTTATTC
TTGGTTCCTGCCTCATCGAGCAATCCGAGGTACAGCGTTTGGAAATTGAATCTGGGACAACTACAGCCGTTAGGAACCAC
GATCAACTCTTTATGAGCAGCCTTGAGATTATTATCGCTGGATTGAAATCACAGGGGTTTTCCTAA

Upstream 100 bases:

>100_bases
TCACATACATTACGGTGTTAGTATCGCCTACGACACGTTGTGTCATACATGGACCGCGTTCCCCCATCACGAGCAACCGA
ATCAGGATAGGCTGACTGCT

Downstream 100 bases:

>100_bases
AAGCAGTAGAGTGAGTAGCTATGAACGACTCCCCTGTGACGTCCGATCGTCAAATCTGGCCCGGACAAAGCTACCCACTG
GGCTCTAAATACGACGGAGC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MQLSKESIISASLDILDSYGLADMTMRRLATHLGVAPGALYWHFKNKQALIDAIARHIMAPLIDASPSAYHHDIPSLAFD
VRSLMLRHRDGAELLSAALTDASLRNDIISVVSAILGGCDKAYVGASTLLNFILGSCLIEQSEVQRLEIESGTTTAVRNH
DQLFMSSLEIIIAGLKSQGFS

Sequences:

>Translated_181_residues
MQLSKESIISASLDILDSYGLADMTMRRLATHLGVAPGALYWHFKNKQALIDAIARHIMAPLIDASPSAYHHDIPSLAFD
VRSLMLRHRDGAELLSAALTDASLRNDIISVVSAILGGCDKAYVGASTLLNFILGSCLIEQSEVQRLEIESGTTTAVRNH
DQLFMSSLEIIIAGLKSQGFS
>Mature_181_residues
MQLSKESIISASLDILDSYGLADMTMRRLATHLGVAPGALYWHFKNKQALIDAIARHIMAPLIDASPSAYHHDIPSLAFD
VRSLMLRHRDGAELLSAALTDASLRNDIISVVSAILGGCDKAYVGASTLLNFILGSCLIEQSEVQRLEIESGTTTAVRNH
DQLFMSSLEIIIAGLKSQGFS

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 19595; Mature: 19595

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSKESIISASLDILDSYGLADMTMRRLATHLGVAPGALYWHFKNKQALIDAIARHIMA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHH
PLIDASPSAYHHDIPSLAFDVRSLMLRHRDGAELLSAALTDASLRNDIISVVSAILGGCD
HHHCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KAYVGASTLLNFILGSCLIEQSEVQRLEIESGTTTAVRNHDQLFMSSLEIIIAGLKSQGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
S
C
>Mature Secondary Structure
MQLSKESIISASLDILDSYGLADMTMRRLATHLGVAPGALYWHFKNKQALIDAIARHIMA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHH
PLIDASPSAYHHDIPSLAFDVRSLMLRHRDGAELLSAALTDASLRNDIISVVSAILGGCD
HHHCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KAYVGASTLLNFILGSCLIEQSEVQRLEIESGTTTAVRNHDQLFMSSLEIIIAGLKSQGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6330687; 3208760; 6311683; 3062183 [H]