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The map label for this gene is hisI

Identifier: 38234132

GI number: 38234132

Start: 1585787

End: 1586137

Strand: Reverse

Name: hisI

Synonym: DIP1557

Alternate gene names: 38234132

Gene position: 1586137-1585787 (Counterclockwise)

Preceding gene: 38234133

Following gene: 38234131

Centisome position: 63.74

GC content: 50.43

Gene sequence:

>351_bases
ATGGACGATCCAGCATCCTATGAGCTCGATCCCAGCATAGCGCAGCGAGTCAAATTCAACAGTGCTGGGTTAGTGCCTGC
AGTTGTTCAGTCCACAGATGGGGAAGTTCTCATGCTGGCTTGGATGGATGCTCATGCGTTGGCGTATACCATTGCTACGC
GGAAGGGCACGTATTTTTCTCGTTCCCGAAACGAATATTGGATTAAAGGCCTTACTTCAGGCCACACTCAGCAGGTTACA
GGTCTGCAATTGGACTGTGATGGCGATACCGTGTTGATGACAGTGGTTCAGCAAGGTGGAGCATGTCACACAGGTGACCG
CACCTGCTTTGACGCTGACGTTATCATTTAA

Upstream 100 bases:

>100_bases
AATTTTCCATTTCGGTGAAGTCACAATTTCTGAAGTGAAAAAGCAGGTAGTGGCTGCTGGCTACGAAGTTCGAAGCTAGT
ACATAAGGAAGGAATATCAC

Downstream 100 bases:

>100_bases
TTTTTGGTATAGATCAAAAACGTGAGCTGGAAGGGCGGCAACGCACATGTCTGGTAGGAAGATAGTCTCGGCTTTGGCTA
TCGGACTCGGAGGAATCGTA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MDDPASYELDPSIAQRVKFNSAGLVPAVVQSTDGEVLMLAWMDAHALAYTIATRKGTYFSRSRNEYWIKGLTSGHTQQVT
GLQLDCDGDTVLMTVVQQGGACHTGDRTCFDADVII

Sequences:

>Translated_116_residues
MDDPASYELDPSIAQRVKFNSAGLVPAVVQSTDGEVLMLAWMDAHALAYTIATRKGTYFSRSRNEYWIKGLTSGHTQQVT
GLQLDCDGDTVLMTVVQQGGACHTGDRTCFDADVII
>Mature_116_residues
MDDPASYELDPSIAQRVKFNSAGLVPAVVQSTDGEVLMLAWMDAHALAYTIATRKGTYFSRSRNEYWIKGLTSGHTQQVT
GLQLDCDGDTVLMTVVQQGGACHTGDRTCFDADVII

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=43.8202247191011, Blast_Score=80, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319819, Length=89, Percent_Identity=38.2022471910112, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_CORDI (P60541)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939899.1
- ProteinModelPortal:   P60541
- SMR:   P60541
- GeneID:   2650746
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1557
- NMPDR:   fig|257309.1.peg.1490
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- ProtClustDB:   PRK00051
- BioCyc:   CDIP257309:DIP1557-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 12615; Mature: 12615

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDPASYELDPSIAQRVKFNSAGLVPAVVQSTDGEVLMLAWMDAHALAYTIATRKGTYFS
CCCCCCCEECHHHHHHEECCCCCCCEEEEECCCCCEEEEEEECCCEEEEEEECCCCCEEE
RSRNEYWIKGLTSGHTQQVTGLQLDCDGDTVLMTVVQQGGACHTGDRTCFDADVII
CCCCCEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCCCCEECCCCCEEECEEEC
>Mature Secondary Structure
MDDPASYELDPSIAQRVKFNSAGLVPAVVQSTDGEVLMLAWMDAHALAYTIATRKGTYFS
CCCCCCCEECHHHHHHEECCCCCCCEEEEECCCCCEEEEEEECCCEEEEEEECCCCCEEE
RSRNEYWIKGLTSGHTQQVTGLQLDCDGDTVLMTVVQQGGACHTGDRTCFDADVII
CCCCCEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCCCCEECCCCCEEECEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910