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The map label for this gene is tesB [H]

Identifier: 38233964

GI number: 38233964

Start: 1396358

End: 1397212

Strand: Reverse

Name: tesB [H]

Synonym: DIP1379

Alternate gene names: 38233964

Gene position: 1397212-1396358 (Counterclockwise)

Preceding gene: 38233968

Following gene: 38233963

Centisome position: 56.14

GC content: 49.01

Gene sequence:

>855_bases
ATGGGAAGAATATTTGATGTCCTCGATGTTGAGACTTTAGATGCCAATCTTTTTCGAGGTCCCGTTGTGGAATCGGCGCT
AGCGCGTACCTTCGGCGGGCAAGTTGCCGCCCAAGCGCTTGTATGCGCTACGCAAACGGTCAACACTGAAGACTTTATTG
TGCATTCTCTGCATGGATACTTCGTGTCGGCAGGTGATTCATCAAAACCTACGATTTTTGAAGTTCAACGTATCCGCGAC
GGGCGTAGTTTCATCTCACGGCACATCACGGCTCTGCAAAATGGTCGGCCAATTTTTGGCATGCAGGCCAGCTTCCATAT
AAGAAACGACCACGGACCAGAGCATTCAGATCTCGTACGGCGTGTGCCCCCGCCAGAAGCTGTCCAAATAGACCGAGACG
GACTGCCAGCAAGCTCAAGGGCCTTACTCGATGAATGGGGGGATTGGGATATTCGAAAAATTGCTTCGGAAGACTTTGAG
AAAAATCCATACACTCCAAGTCAACAAGTAGTGTGGTTTAAATCCAAGGAAGCGCTACCTGACGATGAAACATTCCACAT
TTGCACACTGGCATACATGTCAGACATGACTCTTCTTCACTCATCTCTCGTCCCGCACCCTGAAGAGCCAGTAAAACTCG
CATCACTGGATCATGCCATGTGGTTCTTGCGCCCATTCCGAGCCGACGAATGGTTGCTCTACGATCAAGTGTCACCTTCC
GCACACGCGGGACGTGCATTAACGCAAGGAAAAATCTTCAACCTTAATGGTGATTTAGTAGCTATCACAACACAAGAAGG
TTTAACGCGCCACCTCAAACCTGGCGAAGCAGATATTCCATTTGTGTCACAATGA

Upstream 100 bases:

>100_bases
AAATAAATAATGAAATATAAAGTAGGCTAACCCATCAATTTCGTTACACTAGTGGCCATCGATATAGCTCACAAGCCAGA
CCGTGGGAAGAAGAAAACAT

Downstream 100 bases:

>100_bases
ATAAAATAAACAGCAATAAAAAGTGCGATAAACACATAGGACACAAACTCAATATCACATAGCTGTCGTATAATAGCGCC
GTTGCCAAAAACGAGGCATC

Product: putative acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MGRIFDVLDVETLDANLFRGPVVESALARTFGGQVAAQALVCATQTVNTEDFIVHSLHGYFVSAGDSSKPTIFEVQRIRD
GRSFISRHITALQNGRPIFGMQASFHIRNDHGPEHSDLVRRVPPPEAVQIDRDGLPASSRALLDEWGDWDIRKIASEDFE
KNPYTPSQQVVWFKSKEALPDDETFHICTLAYMSDMTLLHSSLVPHPEEPVKLASLDHAMWFLRPFRADEWLLYDQVSPS
AHAGRALTQGKIFNLNGDLVAITTQEGLTRHLKPGEADIPFVSQ

Sequences:

>Translated_284_residues
MGRIFDVLDVETLDANLFRGPVVESALARTFGGQVAAQALVCATQTVNTEDFIVHSLHGYFVSAGDSSKPTIFEVQRIRD
GRSFISRHITALQNGRPIFGMQASFHIRNDHGPEHSDLVRRVPPPEAVQIDRDGLPASSRALLDEWGDWDIRKIASEDFE
KNPYTPSQQVVWFKSKEALPDDETFHICTLAYMSDMTLLHSSLVPHPEEPVKLASLDHAMWFLRPFRADEWLLYDQVSPS
AHAGRALTQGKIFNLNGDLVAITTQEGLTRHLKPGEADIPFVSQ
>Mature_283_residues
GRIFDVLDVETLDANLFRGPVVESALARTFGGQVAAQALVCATQTVNTEDFIVHSLHGYFVSAGDSSKPTIFEVQRIRDG
RSFISRHITALQNGRPIFGMQASFHIRNDHGPEHSDLVRRVPPPEAVQIDRDGLPASSRALLDEWGDWDIRKIASEDFEK
NPYTPSQQVVWFKSKEALPDDETFHICTLAYMSDMTLLHSSLVPHPEEPVKLASLDHAMWFLRPFRADEWLLYDQVSPSA
HAGRALTQGKIFNLNGDLVAITTQEGLTRHLKPGEADIPFVSQ

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=295, Percent_Identity=37.2881355932203, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI1786657, Length=279, Percent_Identity=37.2759856630824, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71988741, Length=300, Percent_Identity=32.6666666666667, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17558508, Length=313, Percent_Identity=32.2683706070287, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17531889, Length=269, Percent_Identity=34.5724907063197, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI115532456, Length=269, Percent_Identity=34.5724907063197, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531885, Length=269, Percent_Identity=34.5724907063197, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71982224, Length=294, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI212645202, Length=282, Percent_Identity=27.6595744680851, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31755; Mature: 31624

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRIFDVLDVETLDANLFRGPVVESALARTFGGQVAAQALVCATQTVNTEDFIVHSLHGY
CCCEECEEEEEECCCHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHEEEEECCE
FVSAGDSSKPTIFEVQRIRDGRSFISRHITALQNGRPIFGMQASFHIRNDHGPEHSDLVR
EEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEECEEEEEEECCCCCCHHHHHH
RVPPPEAVQIDRDGLPASSRALLDEWGDWDIRKIASEDFEKNPYTPSQQVVWFKSKEALP
CCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
DDETFHICTLAYMSDMTLLHSSLVPHPEEPVKLASLDHAMWFLRPFRADEWLLYDQVSPS
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCEEEEECCCCC
AHAGRALTQGKIFNLNGDLVAITTQEGLTRHLKPGEADIPFVSQ
CCCCCEECCCEEEECCCCEEEEECCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
GRIFDVLDVETLDANLFRGPVVESALARTFGGQVAAQALVCATQTVNTEDFIVHSLHGY
CCEECEEEEEECCCHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHEEEEECCE
FVSAGDSSKPTIFEVQRIRDGRSFISRHITALQNGRPIFGMQASFHIRNDHGPEHSDLVR
EEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEECEEEEEEECCCCCCHHHHHH
RVPPPEAVQIDRDGLPASSRALLDEWGDWDIRKIASEDFEKNPYTPSQQVVWFKSKEALP
CCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
DDETFHICTLAYMSDMTLLHSSLVPHPEEPVKLASLDHAMWFLRPFRADEWLLYDQVSPS
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCEEEEECCCCC
AHAGRALTQGKIFNLNGDLVAITTQEGLTRHLKPGEADIPFVSQ
CCCCCEECCCEEEECCCCEEEEECCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]