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The map label for this gene is aroE [H]

Identifier: 38233933

GI number: 38233933

Start: 1359196

End: 1360065

Strand: Reverse

Name: aroE [H]

Synonym: DIP1347

Alternate gene names: 38233933

Gene position: 1360065-1359196 (Counterclockwise)

Preceding gene: 38233934

Following gene: 38233931

Centisome position: 54.65

GC content: 46.44

Gene sequence:

>870_bases
TTGCCAGGTCATTTTATACTGACCATTATGATTCACTTTCGAGCAGCCGTCTTAGGACACCCCATTGAGCATTCCTTATC
TCCGTTACTTCATAACGCTGGTTATGCGGCTTTAGGTCTTTCGCAATGGTCTTATGGACGATTTGATTGTGATTCACAGC
AGTTATCTGAATTAGTCGATAAATGTGATCCATCATTTCAGGGTTTCTCAGTAACAATGCCGTGCAAATTTGAGGCGTTA
GAATACGCAACGTCGGTAAGCGAACGTGCACAGAGAATTGGCTCTGCAAATACTTTGGTCCGAGCTGAAAATGGCTGGTA
TGCGGACAACACGGATACAGAGGGGGTTCGCGGTGCCTTGGAGATCCTTTTTAGTGATCGGGGCGGTGCTGCGGAGGCAC
TCAAAAATACAAGGGCAATAGTTGTCGGTGCTGGAGGTACGTCTCGGCCAGCAATCTGGACATTAGGTACTTTAGGCGTC
GCAGAAATAGTTGTGGTCAATAGAAGCGATCGTCGTGAAGAATTGGAACCAGTTCTAGAAGGGGAACCCACCAAAATAAG
TTTTGTTGGGTTTGATTCAAATCTTCGGTCACACGCGCAGTCAGCTTCAGTGGTTATTTCGACTGTGCCGTCTGTTGGGG
TGTCAGATTATATTGATGACCTAGTGCATGCTCCAGTTCTCGATGTCATTTATGATCCGTGGCCGACACCATTAATCCAA
CATGCTCAAAAGAAAGGCGTGCCGTGTATAGGTGGACACATAATGCTTTTGCACCAAGCTTTGAGCCAGTTTGAACAATT
TACGGGGGTAAAGGCACCTCGCGAAGCAATGCAAAAAGCACTGTTTGACCACCTGTTTGGGGACAATTAA

Upstream 100 bases:

>100_bases
CGATAAGCGTTAATGCGCCTTGTGGCCTTATCCTAAACAATCAGGATAAGGCCATTTTATTTTTGTTACGAACCTAAAAG
CGGCTTGGCGGGGGTATCTA

Downstream 100 bases:

>100_bases
TCCTGAGAACAGTGCTTCCCCCATACAATAGAGCGCATGGGGGAAGCACTTAAAATATTGGGAATAACTAGTGTCGGATC
GTGGTGGGCCTTTCGGCTGA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MPGHFILTIMIHFRAAVLGHPIEHSLSPLLHNAGYAALGLSQWSYGRFDCDSQQLSELVDKCDPSFQGFSVTMPCKFEAL
EYATSVSERAQRIGSANTLVRAENGWYADNTDTEGVRGALEILFSDRGGAAEALKNTRAIVVGAGGTSRPAIWTLGTLGV
AEIVVVNRSDRREELEPVLEGEPTKISFVGFDSNLRSHAQSASVVISTVPSVGVSDYIDDLVHAPVLDVIYDPWPTPLIQ
HAQKKGVPCIGGHIMLLHQALSQFEQFTGVKAPREAMQKALFDHLFGDN

Sequences:

>Translated_289_residues
MPGHFILTIMIHFRAAVLGHPIEHSLSPLLHNAGYAALGLSQWSYGRFDCDSQQLSELVDKCDPSFQGFSVTMPCKFEAL
EYATSVSERAQRIGSANTLVRAENGWYADNTDTEGVRGALEILFSDRGGAAEALKNTRAIVVGAGGTSRPAIWTLGTLGV
AEIVVVNRSDRREELEPVLEGEPTKISFVGFDSNLRSHAQSASVVISTVPSVGVSDYIDDLVHAPVLDVIYDPWPTPLIQ
HAQKKGVPCIGGHIMLLHQALSQFEQFTGVKAPREAMQKALFDHLFGDN
>Mature_288_residues
PGHFILTIMIHFRAAVLGHPIEHSLSPLLHNAGYAALGLSQWSYGRFDCDSQQLSELVDKCDPSFQGFSVTMPCKFEALE
YATSVSERAQRIGSANTLVRAENGWYADNTDTEGVRGALEILFSDRGGAAEALKNTRAIVVGAGGTSRPAIWTLGTLGVA
EIVVVNRSDRREELEPVLEGEPTKISFVGFDSNLRSHAQSASVVISTVPSVGVSDYIDDLVHAPVLDVIYDPWPTPLIQH
AQKKGVPCIGGHIMLLHQALSQFEQFTGVKAPREAMQKALFDHLFGDN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=283, Percent_Identity=27.5618374558304, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789675, Length=285, Percent_Identity=30.5263157894737, Blast_Score=81, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=288, Percent_Identity=34.375, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31397; Mature: 31266

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGHFILTIMIHFRAAVLGHPIEHSLSPLLHNAGYAALGLSQWSYGRFDCDSQQLSELVD
CCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHH
KCDPSFQGFSVTMPCKFEALEYATSVSERAQRIGSANTLVRAENGWYADNTDTEGVRGAL
HCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCCHHHHHHH
EILFSDRGGAAEALKNTRAIVVGAGGTSRPAIWTLGTLGVAEIVVVNRSDRREELEPVLE
HHHCCCCCCHHHHHCCCCEEEEECCCCCCCCEEEECHHCEEEEEEECCCCCHHHHHHHHC
GEPTKISFVGFDSNLRSHAQSASVVISTVPSVGVSDYIDDLVHAPVLDVIYDPWPTPLIQ
CCCCEEEEEECCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHH
HAQKKGVPCIGGHIMLLHQALSQFEQFTGVKAPREAMQKALFDHLFGDN
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PGHFILTIMIHFRAAVLGHPIEHSLSPLLHNAGYAALGLSQWSYGRFDCDSQQLSELVD
CCCEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHH
KCDPSFQGFSVTMPCKFEALEYATSVSERAQRIGSANTLVRAENGWYADNTDTEGVRGAL
HCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCCHHHHHHH
EILFSDRGGAAEALKNTRAIVVGAGGTSRPAIWTLGTLGVAEIVVVNRSDRREELEPVLE
HHHCCCCCCHHHHHCCCCEEEEECCCCCCCCEEEECHHCEEEEEEECCCCCHHHHHHHHC
GEPTKISFVGFDSNLRSHAQSASVVISTVPSVGVSDYIDDLVHAPVLDVIYDPWPTPLIQ
CCCCEEEEEECCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHH
HAQKKGVPCIGGHIMLLHQALSQFEQFTGVKAPREAMQKALFDHLFGDN
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]