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The map label for this gene is fmt

Identifier: 38233908

GI number: 38233908

Start: 1334003

End: 1334938

Strand: Reverse

Name: fmt

Synonym: DIP1322

Alternate gene names: 38233908

Gene position: 1334938-1334003 (Counterclockwise)

Preceding gene: 38233909

Following gene: 38233907

Centisome position: 53.64

GC content: 49.79

Gene sequence:

>936_bases
ATGCGTCTAATTTTTGCTGGAACACCTGAGCCTGCAGTTGTAGTTTTATCCCGATTGCTCGAAAGCGAACATGAGGTCGT
AGCGGTGTTAACCCGTCCTGATGCACGTCGTGGACGTGGAAGGACTCTGCACCCTTCACCTGTGTCGGAGCTTGCGCAAC
AACACGGCATCGAAGTGCTAACTCCGGCTACGATCAAGCCAAATACTCCTGATGGCGACGCTTTTCGAGCCCGTCTCACC
GAGCTAGCACCAGACTGTGTTCCAGTAGTTGCATACGGAAACCTCATTACAGAGGATCTTTTACAAGCTGTTCCGCATGG
ATGGATCAATCTGCATTTCTCGCTCTTGCCACGTTGGCGTGGCGCAGCCCCAGTTCAGGCTGCTATCGCCGCTGGAGACA
CGTCGACGGGTGCTACTACTTTTAGAATTGATAAAGGACTCGATACCGGTCAAATTCTCGGAGTAATTCACGAGCCGATT
CAATCAACTGATACCGCTGACGATTTACTCACTCGGCTGGCGTACTCAGGTGCAGATCTTCTGGTTAACACTATGGATAA
TTTGGCGCAGGGAATTGCTACATACAGTGAGCAAATTGGCACTGCGACGTATGCACCTAAGATAACAACAGAGGACGCAC
GAATTCAGTGGACACATCCAGCCGAAGCCGTCGACAAGCATATTCGTGCTGTTACACCAGGTCCAGGGGCTTGGAGTTTA
CTAGGTGACCAGCGCTTTAAAATTGGCCCTGTAAGCGTGGCAGAAGAATCAGATTTACAACCAGGACACATGAGAATTGA
AAAAAACCGTGTGTTAGTAGGAACCGGCGATCTTAATATTGAGCTTGACCAAATTCAGCCGCAAGGGAAGAAAAGAATGA
AGGCATCTGATTGGGCTCGCGGATTGCAAAACACAGAAGGCTTGGTGCTGTCATGA

Upstream 100 bases:

>100_bases
TGATAAAGTCCACCGGAAAGACGCAATGGCTCAGATCAGGAAGTCTGAGTGGTTTAATCAATAGCTATAGAGTCCGACTC
GAAGACTTAATGAGGAAAGT

Downstream 100 bases:

>100_bases
GTGGTGGTTTTCGTTCCCGTTCGCGCTCAGGCGACCATCTTCCCGTACGTAGTGAAAAGAAGCAATCTACAAATAGGTCT
CGCCAACCAAAGAGATCATC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRLIFAGTPEPAVVVLSRLLESEHEVVAVLTRPDARRGRGRTLHPSPVSELAQQHGIEVLTPATIKPNTPDGDAFRARLT
ELAPDCVPVVAYGNLITEDLLQAVPHGWINLHFSLLPRWRGAAPVQAAIAAGDTSTGATTFRIDKGLDTGQILGVIHEPI
QSTDTADDLLTRLAYSGADLLVNTMDNLAQGIATYSEQIGTATYAPKITTEDARIQWTHPAEAVDKHIRAVTPGPGAWSL
LGDQRFKIGPVSVAEESDLQPGHMRIEKNRVLVGTGDLNIELDQIQPQGKKRMKASDWARGLQNTEGLVLS

Sequences:

>Translated_311_residues
MRLIFAGTPEPAVVVLSRLLESEHEVVAVLTRPDARRGRGRTLHPSPVSELAQQHGIEVLTPATIKPNTPDGDAFRARLT
ELAPDCVPVVAYGNLITEDLLQAVPHGWINLHFSLLPRWRGAAPVQAAIAAGDTSTGATTFRIDKGLDTGQILGVIHEPI
QSTDTADDLLTRLAYSGADLLVNTMDNLAQGIATYSEQIGTATYAPKITTEDARIQWTHPAEAVDKHIRAVTPGPGAWSL
LGDQRFKIGPVSVAEESDLQPGHMRIEKNRVLVGTGDLNIELDQIQPQGKKRMKASDWARGLQNTEGLVLS
>Mature_311_residues
MRLIFAGTPEPAVVVLSRLLESEHEVVAVLTRPDARRGRGRTLHPSPVSELAQQHGIEVLTPATIKPNTPDGDAFRARLT
ELAPDCVPVVAYGNLITEDLLQAVPHGWINLHFSLLPRWRGAAPVQAAIAAGDTSTGATTFRIDKGLDTGQILGVIHEPI
QSTDTADDLLTRLAYSGADLLVNTMDNLAQGIATYSEQIGTATYAPKITTEDARIQWTHPAEAVDKHIRAVTPGPGAWSL
LGDQRFKIGPVSVAEESDLQPGHMRIEKNRVLVGTGDLNIELDQIQPQGKKRMKASDWARGLQNTEGLVLS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=190, Percent_Identity=32.6315789473684, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI21614513, Length=300, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI238814322, Length=238, Percent_Identity=31.9327731092437, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789683, Length=301, Percent_Identity=41.1960132890365, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1788589, Length=310, Percent_Identity=30, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI133930964, Length=335, Percent_Identity=25.9701492537313, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319458, Length=209, Percent_Identity=31.1004784688995, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550868, Length=240, Percent_Identity=32.0833333333333, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28571984, Length=224, Percent_Identity=32.1428571428571, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24585660, Length=332, Percent_Identity=27.710843373494, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_CORDI (Q6NH23)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939675.1
- ProteinModelPortal:   Q6NH23
- SMR:   Q6NH23
- GeneID:   2649876
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1322
- NMPDR:   fig|257309.1.peg.1266
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- BioCyc:   CDIP257309:DIP1322-MONOMER
- BRENDA:   2.1.2.9
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33591; Mature: 33591

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIFAGTPEPAVVVLSRLLESEHEVVAVLTRPDARRGRGRTLHPSPVSELAQQHGIEVL
CEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEE
TPATIKPNTPDGDAFRARLTELAPDCVPVVAYGNLITEDLLQAVPHGWINLHFSLLPRWR
ECCEECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
GAAPVQAAIAAGDTSTGATTFRIDKGLDTGQILGVIHEPIQSTDTADDLLTRLAYSGADL
CCCCHHHHEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHH
LVNTMDNLAQGIATYSEQIGTATYAPKITTEDARIQWTHPAEAVDKHIRAVTPGPGAWSL
HHHHHHHHHHHHHHHHHHHCCEECCCCEECCCCEEEECCCHHHHHHHHEECCCCCCCEEC
LGDQRFKIGPVSVAEESDLQPGHMRIEKNRVLVGTGDLNIELDQIQPQGKKRMKASDWAR
CCCCCEEECCCCCCCCCCCCCCCEEEECCEEEEECCCCEEEECCCCCCHHHHCCHHHHHH
GLQNTEGLVLS
HCCCCCCEEEC
>Mature Secondary Structure
MRLIFAGTPEPAVVVLSRLLESEHEVVAVLTRPDARRGRGRTLHPSPVSELAQQHGIEVL
CEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEE
TPATIKPNTPDGDAFRARLTELAPDCVPVVAYGNLITEDLLQAVPHGWINLHFSLLPRWR
ECCEECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
GAAPVQAAIAAGDTSTGATTFRIDKGLDTGQILGVIHEPIQSTDTADDLLTRLAYSGADL
CCCCHHHHEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHH
LVNTMDNLAQGIATYSEQIGTATYAPKITTEDARIQWTHPAEAVDKHIRAVTPGPGAWSL
HHHHHHHHHHHHHHHHHHHCCEECCCCEECCCCEEEECCCHHHHHHHHEECCCCCCCEEC
LGDQRFKIGPVSVAEESDLQPGHMRIEKNRVLVGTGDLNIELDQIQPQGKKRMKASDWAR
CCCCCEEECCCCCCCCCCCCCCCEEEECCEEEEECCCCEEEECCCCCCHHHHCCHHHHHH
GLQNTEGLVLS
HCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910