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The map label for this gene is ribE [H]

Identifier: 38233904

GI number: 38233904

Start: 1330056

End: 1330664

Strand: Reverse

Name: ribE [H]

Synonym: DIP1318

Alternate gene names: 38233904

Gene position: 1330664-1330056 (Counterclockwise)

Preceding gene: 38233905

Following gene: 38233903

Centisome position: 53.47

GC content: 46.14

Gene sequence:

>609_bases
ATGTTTACTGGGTTAATAGAAGAAATCGGAACGATTACTGGAATGGAAGAGCAAGGAGACTCACTCGTTCTCAGCATTTC
AGCACCGGCACTTATGGTTGATGTGAAGCAAGGCGATTCAATTTCAGTCAACGGTGTGTGCTTGACCGTTGTTATTTGTG
ACGCGACTGGCTTCACAGCTGATGTAATGAGGGAGTCTCTCGATCGTTCTAGTCTGGGTCAACTCCGAACCGGCAGCTAC
GTAAATCTGGAACGCGCCATGCGTGCGGATGCTCGCATGGGAGGGCATATCGTGCAAGGTCATGTTGATGGCACTGGTGT
GCTGTTGTCTCGGGATCATTCGGAACATTGGGATGTATTGCGATTTAGTCTTCCAGCAGATATTTCGCAGTATGTGGTTG
AAAAAGGTTCGATTGCTGTTGACGGAACTTCATTGACGGTGTCGTCGATAAGCGAACCTCTTGCAGAAAATCATTGGTTT
GAAGTTTCGTTAATTCCCACCACTTTGGAGCACACTACGCTCGGTGAGCTAAAACTACGTGAGGTTGTGAATTTAGAAGT
AGACATCGTTGGAAAATATGTTGAACGAATGCTTGCAGGACATAAATAA

Upstream 100 bases:

>100_bases
TTCGATGCTCGGGGACGATATTCTTCAAGTAATTAATATTTGATCTGAACACCGAGTGGTTGTGACGAAATCTCATCGAA
AAAATAAAAGGATTAGCAAA

Downstream 100 bases:

>100_bases
CATCACAAATAGCGAGAAACGAGTAAGGTAGTGCGGGTGGATATAACCCGAAGCGGTACGCCTCATAACAACGAGGCTTA
CCCGATAGATCAGCAGAATA

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFTGLIEEIGTITGMEEQGDSLVLSISAPALMVDVKQGDSISVNGVCLTVVICDATGFTADVMRESLDRSSLGQLRTGSY
VNLERAMRADARMGGHIVQGHVDGTGVLLSRDHSEHWDVLRFSLPADISQYVVEKGSIAVDGTSLTVSSISEPLAENHWF
EVSLIPTTLEHTTLGELKLREVVNLEVDIVGKYVERMLAGHK

Sequences:

>Translated_202_residues
MFTGLIEEIGTITGMEEQGDSLVLSISAPALMVDVKQGDSISVNGVCLTVVICDATGFTADVMRESLDRSSLGQLRTGSY
VNLERAMRADARMGGHIVQGHVDGTGVLLSRDHSEHWDVLRFSLPADISQYVVEKGSIAVDGTSLTVSSISEPLAENHWF
EVSLIPTTLEHTTLGELKLREVVNLEVDIVGKYVERMLAGHK
>Mature_202_residues
MFTGLIEEIGTITGMEEQGDSLVLSISAPALMVDVKQGDSISVNGVCLTVVICDATGFTADVMRESLDRSSLGQLRTGSY
VNLERAMRADARMGGHIVQGHVDGTGVLLSRDHSEHWDVLRFSLPADISQYVVEKGSIAVDGTSLTVSSISEPLAENHWF
EVSLIPTTLEHTTLGELKLREVVNLEVDIVGKYVERMLAGHK

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=211, Percent_Identity=34.5971563981043, Blast_Score=114, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319733, Length=206, Percent_Identity=37.378640776699, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 21867; Mature: 21867

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGLIEEIGTITGMEEQGDSLVLSISAPALMVDVKQGDSISVNGVCLTVVICDATGFTA
CCCHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCEEEECCEEEEEEEECCCCCHH
DVMRESLDRSSLGQLRTGSYVNLERAMRADARMGGHIVQGHVDGTGVLLSRDHSEHWDVL
HHHHHHCCHHHCCCCCCCCEECHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCEE
RFSLPADISQYVVEKGSIAVDGTSLTVSSISEPLAENHWFEVSLIPTTLEHTTLGELKLR
EEECCCCHHHHHHHCCCEEECCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEH
EVVNLEVDIVGKYVERMLAGHK
HHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGLIEEIGTITGMEEQGDSLVLSISAPALMVDVKQGDSISVNGVCLTVVICDATGFTA
CCCHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCEEEECCEEEEEEEECCCCCHH
DVMRESLDRSSLGQLRTGSYVNLERAMRADARMGGHIVQGHVDGTGVLLSRDHSEHWDVL
HHHHHHCCHHHCCCCCCCCEECHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCEE
RFSLPADISQYVVEKGSIAVDGTSLTVSSISEPLAENHWFEVSLIPTTLEHTTLGELKLR
EEECCCCHHHHHHHCCCEEECCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEH
EVVNLEVDIVGKYVERMLAGHK
HHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]