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The map label for this gene is ribA [H]

Identifier: 38233903

GI number: 38233903

Start: 1328703

End: 1329941

Strand: Reverse

Name: ribA [H]

Synonym: DIP1317

Alternate gene names: 38233903

Gene position: 1329941-1328703 (Counterclockwise)

Preceding gene: 38233904

Following gene: 38233902

Centisome position: 53.44

GC content: 49.72

Gene sequence:

>1239_bases
GTGACTTTGGATAGCATCGAAAGGGCCATCGCGGATATTGCGAATGGAAAGCCTGTGGTCGTAGTCGACTCAGAAGATCG
TGAAAACGAAGGCGATTTAATTTTTGCGGCTGATAAAGCAACGCCAGAGTTAGTAGCCTTTATGGTTCGATATTCTTCGG
GTTATATATGTGCCTCTTTGACGTCAGAAGAGTGCGATCGACTTCAGCTTCCGCCAATGACATCCCATAACGAGGATGCG
CGGGGTACCGCATATGCCGTCACGGTAGACGCGAATACAGGAACAACTGGTATTTCTGCAACAAGTCGTGCAGATACGTT
GAGGAAACTTGCCGACAGTCAATTCGGACCTCAAGATTTCACGCGTCCTGGCCATGTGGTTCCACTGCGTGCGAAAGCAG
GAGGTGTGCTTGAACGGGCAGGGCATACTGAAGCGGCTGTCGATCTAGCTCGAATGGCTGGCTTGAATCCAGCAGGCGTC
CTGTGTGAAGTCGTCAGCGAAGATGATCCCACAGACATGGCACGAGCACCTGAACTACGACGATTTGCGGATCGACATGA
TCTTGCACTTATTTCGATTGAACAGCTTATTGAGTGGCGACGTAGGTACGAATTACTTGTTGAACGAGCCGTGTCAACAC
AACTGCCAACTGAGTTCGGACGGTTTACCGCGGTCGGCTATCGTGGAATCGTTGACGGTGTAGAACATATTGCGCTAGTT
GCAGGCGATATTACTTCTGATGAGGGCAAGGATGTTCTCCTTAGAGTCCATTCTGAATGCTTGACCGGAGATGTTTTGGG
TTCTCGTCGGTGTGACTGTGGGCCGCAATTACAGGCGTCCCTTCGTGCTATTTCCGAGCGAGGGCGCGGAGTCGTGGTGT
ACTTGCGTGGACATGAAGGACGTGGAATCGGATTACTTCACAAGCTTCAGGCGTATCATCTGCAAGATGAAGGGGCCGAT
ACGGTTGACGCAAATAAGGCATTAGGCCTACCAGTTGACGCCCGTAATTACTCTGTTGCTGCACACATTCTACGAGATCT
TGGCGTGCAGTCGGTATGTTTGCTGACGAATAATCCAGAAAAATCCCTTGAACTGGAACGCTATGGGGTCAAAGTAACTG
GACGAGAGCCTGTCAAAGTGGAAGTGCACGAAGATAATATTCGTTATTTGACCACAAAACGGGATCGAATGAACCATGAT
CTGCCATGGATTGCCGAATACAAAAAGGAGCAAAGCTAA

Upstream 100 bases:

>100_bases
AGAAACGAGTAAGGTAGTGCGGGTGGATATAACCCGAAGCGGTACGCCTCATAACAACGAGGCTTACCCGATAGATCAGC
AGAATAACGATCATCCAGGG

Downstream 100 bases:

>100_bases
GTGAGCAAAGAGGGACTGCCCAATGTATCTTCGGTAGCAGGAGCAGGTCTTGTTGTCGGAATAGTCTCCGCAACGTGGAA
TGAAAAGATCTGTAATCAGC

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTLDSIERAIADIANGKPVVVVDSEDRENEGDLIFAADKATPELVAFMVRYSSGYICASLTSEECDRLQLPPMTSHNEDA
RGTAYAVTVDANTGTTGISATSRADTLRKLADSQFGPQDFTRPGHVVPLRAKAGGVLERAGHTEAAVDLARMAGLNPAGV
LCEVVSEDDPTDMARAPELRRFADRHDLALISIEQLIEWRRRYELLVERAVSTQLPTEFGRFTAVGYRGIVDGVEHIALV
AGDITSDEGKDVLLRVHSECLTGDVLGSRRCDCGPQLQASLRAISERGRGVVVYLRGHEGRGIGLLHKLQAYHLQDEGAD
TVDANKALGLPVDARNYSVAAHILRDLGVQSVCLLTNNPEKSLELERYGVKVTGREPVKVEVHEDNIRYLTTKRDRMNHD
LPWIAEYKKEQS

Sequences:

>Translated_412_residues
MTLDSIERAIADIANGKPVVVVDSEDRENEGDLIFAADKATPELVAFMVRYSSGYICASLTSEECDRLQLPPMTSHNEDA
RGTAYAVTVDANTGTTGISATSRADTLRKLADSQFGPQDFTRPGHVVPLRAKAGGVLERAGHTEAAVDLARMAGLNPAGV
LCEVVSEDDPTDMARAPELRRFADRHDLALISIEQLIEWRRRYELLVERAVSTQLPTEFGRFTAVGYRGIVDGVEHIALV
AGDITSDEGKDVLLRVHSECLTGDVLGSRRCDCGPQLQASLRAISERGRGVVVYLRGHEGRGIGLLHKLQAYHLQDEGAD
TVDANKALGLPVDARNYSVAAHILRDLGVQSVCLLTNNPEKSLELERYGVKVTGREPVKVEVHEDNIRYLTTKRDRMNHD
LPWIAEYKKEQS
>Mature_411_residues
TLDSIERAIADIANGKPVVVVDSEDRENEGDLIFAADKATPELVAFMVRYSSGYICASLTSEECDRLQLPPMTSHNEDAR
GTAYAVTVDANTGTTGISATSRADTLRKLADSQFGPQDFTRPGHVVPLRAKAGGVLERAGHTEAAVDLARMAGLNPAGVL
CEVVSEDDPTDMARAPELRRFADRHDLALISIEQLIEWRRRYELLVERAVSTQLPTEFGRFTAVGYRGIVDGVEHIALVA
GDITSDEGKDVLLRVHSECLTGDVLGSRRCDCGPQLQASLRAISERGRGVVVYLRGHEGRGIGLLHKLQAYHLQDEGADT
VDANKALGLPVDARNYSVAAHILRDLGVQSVCLLTNNPEKSLELERYGVKVTGREPVKVEVHEDNIRYLTTKRDRMNHDL
PWIAEYKKEQS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=47.2906403940887, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=48.2051282051282, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=46.5686274509804, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6319438, Length=185, Percent_Identity=45.4054054054054, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 45176; Mature: 45045

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDSIERAIADIANGKPVVVVDSEDRENEGDLIFAADKATPELVAFMVRYSSGYICASL
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEC
TSEECDRLQLPPMTSHNEDARGTAYAVTVDANTGTTGISATSRADTLRKLADSQFGPQDF
CHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHC
TRPGHVVPLRAKAGGVLERAGHTEAAVDLARMAGLNPAGVLCEVVSEDDPTDMARAPELR
CCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHEECCCCCCCHHHCCCHHH
RFADRHDLALISIEQLIEWRRRYELLVERAVSTQLPTEFGRFTAVGYRGIVDGVEHIALV
HHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECHHHHHHHHHHEEEE
AGDITSDEGKDVLLRVHSECLTGDVLGSRRCDCGPQLQASLRAISERGRGVVVYLRGHEG
ECCCCCCCCCHHHHEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCC
RGIGLLHKLQAYHLQDEGADTVDANKALGLPVDARNYSVAAHILRDLGVQSVCLLTNNPE
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCH
KSLELERYGVKVTGREPVKVEVHEDNIRYLTTKRDRMNHDLPWIAEYKKEQS
HCEEHHHCCEEEECCCCEEEEEECCCEEEEEECHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TLDSIERAIADIANGKPVVVVDSEDRENEGDLIFAADKATPELVAFMVRYSSGYICASL
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEC
TSEECDRLQLPPMTSHNEDARGTAYAVTVDANTGTTGISATSRADTLRKLADSQFGPQDF
CHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHC
TRPGHVVPLRAKAGGVLERAGHTEAAVDLARMAGLNPAGVLCEVVSEDDPTDMARAPELR
CCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHEECCCCCCCHHHCCCHHH
RFADRHDLALISIEQLIEWRRRYELLVERAVSTQLPTEFGRFTAVGYRGIVDGVEHIALV
HHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECHHHHHHHHHHEEEE
AGDITSDEGKDVLLRVHSECLTGDVLGSRRCDCGPQLQASLRAISERGRGVVVYLRGHEG
ECCCCCCCCCHHHHEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCC
RGIGLLHKLQAYHLQDEGADTVDANKALGLPVDARNYSVAAHILRDLGVQSVCLLTNNPE
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCH
KSLELERYGVKVTGREPVKVEVHEDNIRYLTTKRDRMNHDLPWIAEYKKEQS
HCEEHHHCCEEEECCCCEEEEEECCCEEEEEECHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA