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The map label for this gene is pgk

Identifier: 38233895

GI number: 38233895

Start: 1319763

End: 1320980

Strand: Reverse

Name: pgk

Synonym: DIP1309

Alternate gene names: 38233895

Gene position: 1320980-1319763 (Counterclockwise)

Preceding gene: 38233896

Following gene: 38233894

Centisome position: 53.08

GC content: 49.75

Gene sequence:

>1218_bases
ATGGCTATTAAAACTCTTAAAGATCTCTTGGCAGAAGGCGTTGAAGGACGCCACGTGCTTGTTCGTTCAGATTTCAATGT
ACCGCTGAACGATGATCGTGAAATTACTGATGCTGGACGTATTACCGCCTCGCTCCCAACGATCAAAGCATTAGTTGACA
ACGGTGCTCGAGTAATCTTGATGGCTCACTTGGGCCGCCCCAAGGGAGAAGTAAATGAAAAATTCTCACTGGCTCCTGTA
GCGGAGGCATTGTCTGAAGCCCTTGGACAGTATGTCGCACTCGCAGGCGACGTCGTTGGTGAAGATGCTCATGAACGCGC
GAACGGTCTCAATGACGGTGACGTTCTGCTCCTTGAAAACGTTCGCTTTGATCCACGCGAGACCTCGAAGGAAGAAGCTG
AGCGTGGCGAATTTGCGGATCAGCTTGTCGCACTCACCGCTGAAAATGGTGCTTTCGTATCCGATGGCTTTGGCGTTGTT
CACCGAGCTCAGGCATCAGTATTTGATGTTGCGCAGAGATTGCCGCATTATGCGGGAACACTCGTGGAAAAAGAGCTAGA
AGTTCTTGGAAACAAGGTTGCCTCTGCTCCAGAACGTCCTTATGCGGTCATTCTAGGTGGCGCAAAGGTGTCTGACAAGC
TTGGCGTGATCGAAGCGCTAGCAACAAAGGCTGACAAACTTATTATTGGTGGCGGAATGTGCTACACCTTCTTGGCAGCC
AAAGGTATCAACGTGCAAAAGTCGCTGTTGCAAGAAGAACAAATCAACAAGTGCAAAGAACTTCTAGAAGCATACGCTGA
TAAGATCGTTCTTCCAGTTGATCTGGTAGCAGCTGCAGAGTTCGCCAGCGATGCAGAAAATAAGATCGTTGCAATTGACG
AAATCCCCGAAGGCTGGATGTCTCTTGATGTCGGGCCTAAGACTGTTGAGAAGTTTGCTGAGGTTCTAGCGACATCAAAG
ACCGTATTCTGGAATGGGCCTATGGGCGTTTTTGAGTTTGAAAACTTCTCAGCCGGTACCCGTGGCGTAGCAGAAGCTAT
TATCGCAGCTACGGCTAATGGTGCATTCTCTGTTGTCGGCGGTGGCGATTCGGCTGCTGCTGTTCGACTTCTTGGTCTAG
ACGAGGATGGATTCAGCCATATCTCTACTGGTGGCGGAGCATCACTTGAACTCCTCGAAGGCAAAAACCTTCCTGGCGTT
TCGGTGCTCGAAAGCTAA

Upstream 100 bases:

>100_bases
GCTAACCCTGCGGCCCGGGGTGTACCTCGAGGTACACCCCGGGCCGTGGTGCTTATATTCTTCGCAATACCGAACAACTA
ACCACGGAATAGGTTTTGTT

Downstream 100 bases:

>100_bases
AAGACCTAAAGAGGTAGGCGCGAAAATTCTTTGATACAAGAAGTATTTGCACCTACCTTTTCATTTTGGTTGTTTGCTAA
AACGACCTATTAAAAGGAAG

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MAIKTLKDLLAEGVEGRHVLVRSDFNVPLNDDREITDAGRITASLPTIKALVDNGARVILMAHLGRPKGEVNEKFSLAPV
AEALSEALGQYVALAGDVVGEDAHERANGLNDGDVLLLENVRFDPRETSKEEAERGEFADQLVALTAENGAFVSDGFGVV
HRAQASVFDVAQRLPHYAGTLVEKELEVLGNKVASAPERPYAVILGGAKVSDKLGVIEALATKADKLIIGGGMCYTFLAA
KGINVQKSLLQEEQINKCKELLEAYADKIVLPVDLVAAAEFASDAENKIVAIDEIPEGWMSLDVGPKTVEKFAEVLATSK
TVFWNGPMGVFEFENFSAGTRGVAEAIIAATANGAFSVVGGGDSAAAVRLLGLDEDGFSHISTGGGASLELLEGKNLPGV
SVLES

Sequences:

>Translated_405_residues
MAIKTLKDLLAEGVEGRHVLVRSDFNVPLNDDREITDAGRITASLPTIKALVDNGARVILMAHLGRPKGEVNEKFSLAPV
AEALSEALGQYVALAGDVVGEDAHERANGLNDGDVLLLENVRFDPRETSKEEAERGEFADQLVALTAENGAFVSDGFGVV
HRAQASVFDVAQRLPHYAGTLVEKELEVLGNKVASAPERPYAVILGGAKVSDKLGVIEALATKADKLIIGGGMCYTFLAA
KGINVQKSLLQEEQINKCKELLEAYADKIVLPVDLVAAAEFASDAENKIVAIDEIPEGWMSLDVGPKTVEKFAEVLATSK
TVFWNGPMGVFEFENFSAGTRGVAEAIIAATANGAFSVVGGGDSAAAVRLLGLDEDGFSHISTGGGASLELLEGKNLPGV
SVLES
>Mature_404_residues
AIKTLKDLLAEGVEGRHVLVRSDFNVPLNDDREITDAGRITASLPTIKALVDNGARVILMAHLGRPKGEVNEKFSLAPVA
EALSEALGQYVALAGDVVGEDAHERANGLNDGDVLLLENVRFDPRETSKEEAERGEFADQLVALTAENGAFVSDGFGVVH
RAQASVFDVAQRLPHYAGTLVEKELEVLGNKVASAPERPYAVILGGAKVSDKLGVIEALATKADKLIIGGGMCYTFLAAK
GINVQKSLLQEEQINKCKELLEAYADKIVLPVDLVAAAEFASDAENKIVAIDEIPEGWMSLDVGPKTVEKFAEVLATSKT
VFWNGPMGVFEFENFSAGTRGVAEAIIAATANGAFSVVGGGDSAAAVRLLGLDEDGFSHISTGGGASLELLEGKNLPGVS
VLES

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family

Homologues:

Organism=Homo sapiens, GI4505763, Length=408, Percent_Identity=41.9117647058824, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI31543397, Length=408, Percent_Identity=41.6666666666667, Blast_Score=287, Evalue=2e-77,
Organism=Escherichia coli, GI1789294, Length=407, Percent_Identity=41.7690417690418, Blast_Score=274, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI17508823, Length=402, Percent_Identity=44.2786069651741, Blast_Score=303, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6319857, Length=410, Percent_Identity=42.9268292682927, Blast_Score=296, Evalue=5e-81,
Organism=Drosophila melanogaster, GI17136394, Length=409, Percent_Identity=43.2762836185819, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24581203, Length=405, Percent_Identity=41.7283950617284, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): PGK_CORDI (P62411)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939662.1
- ProteinModelPortal:   P62411
- SMR:   P62411
- GeneID:   2649863
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1309
- NMPDR:   fig|257309.1.peg.1253
- HOGENOM:   HBG453500
- OMA:   DCIGDEV
- PhylomeDB:   P62411
- ProtClustDB:   PRK00073
- BioCyc:   CDIP257309:DIP1309-MONOMER
- BRENDA:   2.7.2.3
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_00145
- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824
- Gene3D:   G3DSA:3.40.50.1270
- Gene3D:   G3DSA:3.40.50.1260
- PANTHER:   PTHR11406
- PIRSF:   PIRSF000724
- PRINTS:   PR00477

Pfam domain/function: PF00162 PGK; SSF53748 PGK

EC number: =2.7.2.3

Molecular weight: Translated: 42666; Mature: 42535

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: BINDING 40-40 BINDING 122-122 BINDING 162-162 BINDING 213-213 BINDING 332-332

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKTLKDLLAEGVEGRHVLVRSDFNVPLNDDREITDAGRITASLPTIKALVDNGARVIL
CCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHCCCCEEEE
MAHLGRPKGEVNEKFSLAPVAEALSEALGQYVALAGDVVGEDAHERANGLNDGDVLLLEN
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEC
VRFDPRETSKEEAERGEFADQLVALTAENGAFVSDGFGVVHRAQASVFDVAQRLPHYAGT
CCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHH
LVEKELEVLGNKVASAPERPYAVILGGAKVSDKLGVIEALATKADKLIIGGGMCYTFLAA
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHH
KGINVQKSLLQEEQINKCKELLEAYADKIVLPVDLVAAAEFASDAENKIVAIDEIPEGWM
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHCCCCCCEEEEECCCCCCE
SLDVGPKTVEKFAEVLATSKTVFWNGPMGVFEFENFSAGTRGVAEAIIAATANGAFSVVG
EECCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEE
GGDSAAAVRLLGLDEDGFSHISTGGGASLELLEGKNLPGVSVLES
CCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHHCCC
>Mature Secondary Structure 
AIKTLKDLLAEGVEGRHVLVRSDFNVPLNDDREITDAGRITASLPTIKALVDNGARVIL
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHCCCCEEEE
MAHLGRPKGEVNEKFSLAPVAEALSEALGQYVALAGDVVGEDAHERANGLNDGDVLLLEN
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEC
VRFDPRETSKEEAERGEFADQLVALTAENGAFVSDGFGVVHRAQASVFDVAQRLPHYAGT
CCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHH
LVEKELEVLGNKVASAPERPYAVILGGAKVSDKLGVIEALATKADKLIIGGGMCYTFLAA
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHH
KGINVQKSLLQEEQINKCKELLEAYADKIVLPVDLVAAAEFASDAENKIVAIDEIPEGWM
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHCCCCCCEEEEECCCCCCE
SLDVGPKTVEKFAEVLATSKTVFWNGPMGVFEFENFSAGTRGVAEAIIAATANGAFSVVG
EECCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEE
GGDSAAAVRLLGLDEDGFSHISTGGGASLELLEGKNLPGVSVLES
CCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910