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The map label for this gene is hemH

Identifier: 38233865

GI number: 38233865

Start: 1287056

End: 1288165

Strand: Reverse

Name: hemH

Synonym: DIP1280

Alternate gene names: 38233865

Gene position: 1288165-1287056 (Counterclockwise)

Preceding gene: 38233866

Following gene: 38233863

Centisome position: 51.76

GC content: 44.32

Gene sequence:

>1110_bases
TTGCTACCGCTGCCTACGTGGACGTTATCGGACGTCGACGCAATATTAGTTCTCTCTTTTGGCGGTCCAGAGGGACAACA
AGATGTCATACCTTTTCTTGAAAATGTAACTCGTGGCAGAGGTATTCCTCGTGAACGCCTCGAAGAAGTTGCGGTTCATT
ACCGACATTTTGGCGGTATAAGTCCGCTTAATGCTCTTAATCGAGAAATTATTGGCAATATCATTGAAGTATTGTCGTCG
CGTGGGCTCGAGATTCCTGTGTATTTTGGAAACAGAAATTGGCACCCATTTGTCAATGACACCGCTGAGAAAATGGTTCG
CGATGGTGTTCGGAATGTCGCAGTTTTTGCTACCTCTGCGTGGGGTGGGTATTCAGGATGTCGACAATATGATGAAGATA
TTGTCAGAATGAATCACCATCTGGAAGAAAAGGAGCTCCCGACTCTTAACTGTTTGAAACTTCGACAATTCTTTGATCAT
CCATTATTTATTGAGGAAATGTCTTCGGTGGTATTTCAAGCCGCAAGAGAATTAGGAATTTCGGCACTTGATGAGCTCCA
GCTGCATCAAAAAGTCGTTTTTACCGCACACTCAATACCTGAAGTAGCCAATGAGAATTCAGGGCGTAAGGAAGACGGGC
CATTATACTCGCGTCAAGTTTACGAAGCAGCGTCACTCGTCGCAAAGCATCTTGGTATAAGCCAAGAGCGTTACGACGTA
GTCTGGCAGTCTGCATCAGGAAATGGTCAAATTCCTTGGTTAGAACCGGATATTTTAGATTATGCGAAATGTCAACATGA
TGAAGGCGTTTCCGAACTCGTTGTTGCACCCATTGGTTTCATTTCAGACCATATGGAAGTTGTGTGGGACTTGGATCATG
AACTCCAAGACTTAGCTTCAGATTTAGGAATGTCAATTTCTAGAGCTGCAACTGTTGGACATACCGATTCCTTCGCAACC
ATGATCGTTGAATTAGTCGAAGAATCATTAGGAGTAAAACCGCACCAGAATCTCGGAACTGTTCCGTCGAAAGGATGCTC
CTTCAACGGTGAACCATGTGAAGTAAATTGTTGTAAGCCAGTTCAGCGACCCCATTCTGCAAAAGCGTAA

Upstream 100 bases:

>100_bases
TAAACGGGTGAAAGTCTCGACCGTGAGGATAACGGTTGCACAAGACTTTCACCCTTTAGTGTTAAGCTAACTGCTTATGG
TCGAACCTGTGCACTCTTCT

Downstream 100 bases:

>100_bases
GAAACCGCTGCCATTCGAGCATGGCGAACGTGTTGTGCTAGGGGAAATAGATGTGGGTCAAAAGCATGCTCCTGTAAAGA
TTGTGTCACGCCTTCAACAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLPLPTWTLSDVDAILVLSFGGPEGQQDVIPFLENVTRGRGIPRERLEEVAVHYRHFGGISPLNALNREIIGNIIEVLSS
RGLEIPVYFGNRNWHPFVNDTAEKMVRDGVRNVAVFATSAWGGYSGCRQYDEDIVRMNHHLEEKELPTLNCLKLRQFFDH
PLFIEEMSSVVFQAARELGISALDELQLHQKVVFTAHSIPEVANENSGRKEDGPLYSRQVYEAASLVAKHLGISQERYDV
VWQSASGNGQIPWLEPDILDYAKCQHDEGVSELVVAPIGFISDHMEVVWDLDHELQDLASDLGMSISRAATVGHTDSFAT
MIVELVEESLGVKPHQNLGTVPSKGCSFNGEPCEVNCCKPVQRPHSAKA

Sequences:

>Translated_369_residues
MLPLPTWTLSDVDAILVLSFGGPEGQQDVIPFLENVTRGRGIPRERLEEVAVHYRHFGGISPLNALNREIIGNIIEVLSS
RGLEIPVYFGNRNWHPFVNDTAEKMVRDGVRNVAVFATSAWGGYSGCRQYDEDIVRMNHHLEEKELPTLNCLKLRQFFDH
PLFIEEMSSVVFQAARELGISALDELQLHQKVVFTAHSIPEVANENSGRKEDGPLYSRQVYEAASLVAKHLGISQERYDV
VWQSASGNGQIPWLEPDILDYAKCQHDEGVSELVVAPIGFISDHMEVVWDLDHELQDLASDLGMSISRAATVGHTDSFAT
MIVELVEESLGVKPHQNLGTVPSKGCSFNGEPCEVNCCKPVQRPHSAKA
>Mature_369_residues
MLPLPTWTLSDVDAILVLSFGGPEGQQDVIPFLENVTRGRGIPRERLEEVAVHYRHFGGISPLNALNREIIGNIIEVLSS
RGLEIPVYFGNRNWHPFVNDTAEKMVRDGVRNVAVFATSAWGGYSGCRQYDEDIVRMNHHLEEKELPTLNCLKLRQFFDH
PLFIEEMSSVVFQAARELGISALDELQLHQKVVFTAHSIPEVANENSGRKEDGPLYSRQVYEAASLVAKHLGISQERYDV
VWQSASGNGQIPWLEPDILDYAKCQHDEGVSELVVAPIGFISDHMEVVWDLDHELQDLASDLGMSISRAATVGHTDSFAT
MIVELVEESLGVKPHQNLGTVPSKGCSFNGEPCEVNCCKPVQRPHSAKA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=334, Percent_Identity=25.748502994012, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI60499025, Length=338, Percent_Identity=26.0355029585799, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=25.5952380952381, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_CORDI (Q6NH66)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939632.1
- ProteinModelPortal:   Q6NH66
- SMR:   Q6NH66
- GeneID:   2649833
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1280
- NMPDR:   fig|257309.1.peg.1223
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK00035
- BioCyc:   CDIP257309:DIP1280-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- PANTHER:   PTHR11108

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41047; Mature: 41047

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLPTWTLSDVDAILVLSFGGPEGQQDVIPFLENVTRGRGIPRERLEEVAVHYRHFGGI
CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
SPLNALNREIIGNIIEVLSSRGLEIPVYFGNRNWHPFVNDTAEKMVRDGVRNVAVFATSA
CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEEECC
WGGYSGCRQYDEDIVRMNHHLEEKELPTLNCLKLRQFFDHPLFIEEMSSVVFQAARELGI
CCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCH
SALDELQLHQKVVFTAHSIPEVANENSGRKEDGPLYSRQVYEAASLVAKHLGISQERYDV
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
VWQSASGNGQIPWLEPDILDYAKCQHDEGVSELVVAPIGFISDHMEVVWDLDHELQDLAS
EEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DLGMSISRAATVGHTDSFATMIVELVEESLGVKPHQNLGTVPSKGCSFNGEPCEVNCCKP
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
VQRPHSAKA
CCCCCCCCC
>Mature Secondary Structure
MLPLPTWTLSDVDAILVLSFGGPEGQQDVIPFLENVTRGRGIPRERLEEVAVHYRHFGGI
CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
SPLNALNREIIGNIIEVLSSRGLEIPVYFGNRNWHPFVNDTAEKMVRDGVRNVAVFATSA
CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEEECC
WGGYSGCRQYDEDIVRMNHHLEEKELPTLNCLKLRQFFDHPLFIEEMSSVVFQAARELGI
CCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCH
SALDELQLHQKVVFTAHSIPEVANENSGRKEDGPLYSRQVYEAASLVAKHLGISQERYDV
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
VWQSASGNGQIPWLEPDILDYAKCQHDEGVSELVVAPIGFISDHMEVVWDLDHELQDLAS
EEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DLGMSISRAATVGHTDSFATMIVELVEESLGVKPHQNLGTVPSKGCSFNGEPCEVNCCKP
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
VQRPHSAKA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910