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The map label for this gene is mutT1 [H]

Identifier: 38233719

GI number: 38233719

Start: 1114111

End: 1115121

Strand: Reverse

Name: mutT1 [H]

Synonym: DIP1129

Alternate gene names: 38233719

Gene position: 1115121-1114111 (Counterclockwise)

Preceding gene: 38233722

Following gene: 38233716

Centisome position: 44.81

GC content: 53.91

Gene sequence:

>1011_bases
ATGACGTCTTCTAACAAGCTCCACGAAGTAGACAAAGACCAACAGTCAGCTTTCGACATCACAGGCCGCTACCAAACAAT
TTCGGCTCATCCCACAAAAGAATTTTCCAAGCCAACCCTGGCAGCGGGTGCTGTTCTATGGCGCCACAGCTCCACAATCA
CGGAAAACCCAGCAGTGGAATTTGCCGTAATCCACCGCCCGCATTACGACGATTGGTCCCTTGCCAAAGGCAAAGTTGAT
CCAGGCGAATCGCTACCGGTCACCGCTGAACGCGAGATCCGTGAAGAGACTGGCCACCACGTTCACTTGGGAAAGCTTCT
CGGGAAAGTGTCCTACCCCGTCGGCGAACGCACCAAAGTGGTGTACTACTGGATCGCCCAAGTCCACGATGAAGCCTTCG
AAGAAAATAACGAAGTAGATGAACTACGCTGGCTCCCCTACACCGAGGCTCGAGAACTTCTCAGCTACGACGTGGACCGC
CTGGTGCTAGACAAGGCCTATAAACGTCTTGCGTTGCCCACCACTACTCGAGTGATTTTGGTGCGTCACGCTAAAGCACA
TCAACGTCACAATTGGGCAGGCAATGACAGCATCCGACCACTGGAGAAAAAGGGCCAGCGCCAAGCAGACCTACTTGGTC
CCATGCTCGCAGCTTACGGCCCAACAAGTATTCATTCCGCCACCCCGGCGCGGTGCCAGCAAACCGCTGCACCGCTATCT
GAGCTTACGGGGTTGGAGGTCGTAGTTGATGATCGTTTTGATGATGAGGCGTGGCTATCGCGTATGACGGTTGCGCAGAA
GGCTTGTGAGGAGCTGATTGCAACTCCTGGTACTCATGTGGTGGTCAGCCAAGGTCTTTTTATTCCTGATGCTATTGCAT
GGTTGTCCGCTCAGGGACGTTTGCCGTTAGAGACCATTGAAGCGAAGAAGGCTAGCGCTTGGGTGCTGTCTTTCCACGAG
GGCGAACTAACAGGTGCGGATTATTTGGTGAGCCCCTTGGGCGTGAAGTAA

Upstream 100 bases:

>100_bases
TATGCGATGGTATTGGGGTGATGGCAATGCCACCGACGGCGTGATCAAGGCTTAAGATTGTTGAAAACCGCATGCACTGC
GAGAAAGGTCACGCATTTTC

Downstream 100 bases:

>100_bases
TCGCTTTCCTGGCATAGTTGTGGGGCCTCGTAGAGTTGTTCGCTCTAGGAAGCCCCACTTTTCTTTGCGGCTGAGGTGTT
ATTGCGTTACCGGTTTGAAG

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTSSNKLHEVDKDQQSAFDITGRYQTISAHPTKEFSKPTLAAGAVLWRHSSTITENPAVEFAVIHRPHYDDWSLAKGKVD
PGESLPVTAEREIREETGHHVHLGKLLGKVSYPVGERTKVVYYWIAQVHDEAFEENNEVDELRWLPYTEARELLSYDVDR
LVLDKAYKRLALPTTTRVILVRHAKAHQRHNWAGNDSIRPLEKKGQRQADLLGPMLAAYGPTSIHSATPARCQQTAAPLS
ELTGLEVVVDDRFDDEAWLSRMTVAQKACEELIATPGTHVVVSQGLFIPDAIAWLSAQGRLPLETIEAKKASAWVLSFHE
GELTGADYLVSPLGVK

Sequences:

>Translated_336_residues
MTSSNKLHEVDKDQQSAFDITGRYQTISAHPTKEFSKPTLAAGAVLWRHSSTITENPAVEFAVIHRPHYDDWSLAKGKVD
PGESLPVTAEREIREETGHHVHLGKLLGKVSYPVGERTKVVYYWIAQVHDEAFEENNEVDELRWLPYTEARELLSYDVDR
LVLDKAYKRLALPTTTRVILVRHAKAHQRHNWAGNDSIRPLEKKGQRQADLLGPMLAAYGPTSIHSATPARCQQTAAPLS
ELTGLEVVVDDRFDDEAWLSRMTVAQKACEELIATPGTHVVVSQGLFIPDAIAWLSAQGRLPLETIEAKKASAWVLSFHE
GELTGADYLVSPLGVK
>Mature_335_residues
TSSNKLHEVDKDQQSAFDITGRYQTISAHPTKEFSKPTLAAGAVLWRHSSTITENPAVEFAVIHRPHYDDWSLAKGKVDP
GESLPVTAEREIREETGHHVHLGKLLGKVSYPVGERTKVVYYWIAQVHDEAFEENNEVDELRWLPYTEARELLSYDVDRL
VLDKAYKRLALPTTTRVILVRHAKAHQRHNWAGNDSIRPLEKKGQRQADLLGPMLAAYGPTSIHSATPARCQQTAAPLSE
LTGLEVVVDDRFDDEAWLSRMTVAQKACEELIATPGTHVVVSQGLFIPDAIAWLSAQGRLPLETIEAKKASAWVLSFHEG
ELTGADYLVSPLGVK

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: NA

Molecular weight: Translated: 37466; Mature: 37334

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSNKLHEVDKDQQSAFDITGRYQTISAHPTKEFSKPTLAAGAVLWRHSSTITENPAVE
CCCCCCCHHCCCHHHHHEEECCCEEEEECCCCHHHCCCHHHHHHHEEECCCCCCCCCCEE
FAVIHRPHYDDWSLAKGKVDPGESLPVTAEREIREETGHHVHLGKLLGKVSYPVGERTKV
EEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCEE
VYYWIAQVHDEAFEENNEVDELRWLPYTEARELLSYDVDRLVLDKAYKRLALPTTTRVIL
EEEHHHHHHHHHHHCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VRHAKAHQRHNWAGNDSIRPLEKKGQRQADLLGPMLAAYGPTSIHSATPARCQQTAAPLS
EECHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHH
ELTGLEVVVDDRFDDEAWLSRMTVAQKACEELIATPGTHVVVSQGLFIPDAIAWLSAQGR
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCC
LPLETIEAKKASAWVLSFHEGELTGADYLVSPLGVK
CCHHHHHCCCCCEEEEEEECCCCCCCHHCCCCCCCC
>Mature Secondary Structure 
TSSNKLHEVDKDQQSAFDITGRYQTISAHPTKEFSKPTLAAGAVLWRHSSTITENPAVE
CCCCCCHHCCCHHHHHEEECCCEEEEECCCCHHHCCCHHHHHHHEEECCCCCCCCCCEE
FAVIHRPHYDDWSLAKGKVDPGESLPVTAEREIREETGHHVHLGKLLGKVSYPVGERTKV
EEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCEE
VYYWIAQVHDEAFEENNEVDELRWLPYTEARELLSYDVDRLVLDKAYKRLALPTTTRVIL
EEEHHHHHHHHHHHCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VRHAKAHQRHNWAGNDSIRPLEKKGQRQADLLGPMLAAYGPTSIHSATPARCQQTAAPLS
EECHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHH
ELTGLEVVVDDRFDDEAWLSRMTVAQKACEELIATPGTHVVVSQGLFIPDAIAWLSAQGR
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCC
LPLETIEAKKASAWVLSFHEGELTGADYLVSPLGVK
CCHHHHHCCCCCEEEEEEECCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]