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The map label for this gene is glpR [H]

Identifier: 37680809

GI number: 37680809

Start: 2654471

End: 2655265

Strand: Direct

Name: glpR [H]

Synonym: VV2625

Alternate gene names: 37680809

Gene position: 2654471-2655265 (Clockwise)

Preceding gene: 37680808

Following gene: 161486609

Centisome position: 79.13

GC content: 48.3

Gene sequence:

>795_bases
ATGAGGCAGAGGCATCAGGGAGACAAAGTGAAACAGATTCCAAGACACCAACAAATTATCGAGATGGTGAAAAAACAAGG
CTACGTGAGCACCGACGAGCTAGTCGAGAAGTTCAATGTCAGCCCACAAACGATTCGCCGCGATCTGAATGAGCTTGCCG
ATGCAAACAAAATTCGCCGCTACCATGGTGGTGCGACCATCCCACTGAGTTCAGAGAACACCTCTTACTCCACGCGTAAA
AAAGAACATTTCACTGAAAAAGATTTGATTGCCGAAGAGTTGGTGCAGCACATTCCCGATGGAGCCACGCTGTTTATTGA
TATCGGCACCACACCAGAAGCGGTCGCCAAAGCACTGAACAAAAACCACAAGCAACTGCGCGTTGTCACCAACAACATCA
ACGTTGCCAGTATTTTGCTGAGCAATCCTGAGATTAAAGTGATTCTCGCCGGTGGCGAAGTTCGCAACCGTGATGGCGGT
ATCGTCGGTGAAGCAACACTCGATTTCATCAAGCAGTTCCGTTTGGACTTCGGCATTCTAGGCATCAGTGGCATCGATTA
CGATGGCTCACTGCTCGATTTCGACTACCATGAAGTGCGCGTGAAACAAGCTATCATCGAAAACAGTCGCAGCGTGTATC
TGGCCGTAGACCACAGTAAATTTGGCCGCAATGCGATGGTTAAGCTGGGGAATATTTCGCAAATCAATATGCTGATCACC
AATGAACAGCCACCAGAAGAGATCACGGCTATTTTGAAAGAACAGCAGATCCCTTGCGTTGTCGCAGGCGAATAA

Upstream 100 bases:

>100_bases
ACACGAATTCTTGACCTCGACAACTTCTATGAACTCATCATTTAGCGCACAATAGCCTGAGTGATTATTTTCGAATGCCA
GCATTTCTGCCAAAAGGATC

Downstream 100 bases:

>100_bases
ACTTAAAACGCGTTTCCAAGCCCCGTCACTGAGTGTCGGGGCTTTTTTTGTGTTCAAATCACACAAACGAGCACAAACGA
AAATAATAGCTGATCTCATT

Product: transcriptional regulator of sugar metabolism

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRQRHQGDKVKQIPRHQQIIEMVKKQGYVSTDELVEKFNVSPQTIRRDLNELADANKIRRYHGGATIPLSSENTSYSTRK
KEHFTEKDLIAEELVQHIPDGATLFIDIGTTPEAVAKALNKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGG
IVGEATLDFIKQFRLDFGILGISGIDYDGSLLDFDYHEVRVKQAIIENSRSVYLAVDHSKFGRNAMVKLGNISQINMLIT
NEQPPEEITAILKEQQIPCVVAGE

Sequences:

>Translated_264_residues
MRQRHQGDKVKQIPRHQQIIEMVKKQGYVSTDELVEKFNVSPQTIRRDLNELADANKIRRYHGGATIPLSSENTSYSTRK
KEHFTEKDLIAEELVQHIPDGATLFIDIGTTPEAVAKALNKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGG
IVGEATLDFIKQFRLDFGILGISGIDYDGSLLDFDYHEVRVKQAIIENSRSVYLAVDHSKFGRNAMVKLGNISQINMLIT
NEQPPEEITAILKEQQIPCVVAGE
>Mature_264_residues
MRQRHQGDKVKQIPRHQQIIEMVKKQGYVSTDELVEKFNVSPQTIRRDLNELADANKIRRYHGGATIPLSSENTSYSTRK
KEHFTEKDLIAEELVQHIPDGATLFIDIGTTPEAVAKALNKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGG
IVGEATLDFIKQFRLDFGILGISGIDYDGSLLDFDYHEVRVKQAIIENSRSVYLAVDHSKFGRNAMVKLGNISQINMLIT
NEQPPEEITAILKEQQIPCVVAGE

Specific function: Repressor of the glycerol-3-phosphate regulon [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=248, Percent_Identity=64.5161290322581, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI87082344, Length=251, Percent_Identity=39.0438247011952, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1788069, Length=248, Percent_Identity=32.258064516129, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI226510968, Length=251, Percent_Identity=30.6772908366534, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789170, Length=233, Percent_Identity=28.755364806867, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=26.8774703557312, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789059, Length=262, Percent_Identity=30.1526717557252, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787540, Length=229, Percent_Identity=30.5676855895196, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790753, Length=238, Percent_Identity=25.6302521008403, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790635, Length=249, Percent_Identity=25.7028112449799, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787063, Length=245, Percent_Identity=24.0816326530612, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29592; Mature: 29592

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQRHQGDKVKQIPRHQQIIEMVKKQGYVSTDELVEKFNVSPQTIRRDLNELADANKIRR
CCCCCCCCHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YHGGATIPLSSENTSYSTRKKEHFTEKDLIAEELVQHIPDGATLFIDIGTTPEAVAKALN
HCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHC
KNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDFIKQFRLDFGIL
CCCCEEEEEECCCCEEEEEECCCCEEEEEECCCEECCCCCEECHHHHHHHHHHHHHHEEE
GISGIDYDGSLLDFDYHEVRVKQAIIENSRSVYLAVDHSKFGRNAMVKLGNISQINMLIT
EECCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCEEEEEEEE
NEQPPEEITAILKEQQIPCVVAGE
CCCCHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRQRHQGDKVKQIPRHQQIIEMVKKQGYVSTDELVEKFNVSPQTIRRDLNELADANKIRR
CCCCCCCCHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YHGGATIPLSSENTSYSTRKKEHFTEKDLIAEELVQHIPDGATLFIDIGTTPEAVAKALN
HCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHC
KNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDFIKQFRLDFGIL
CCCCEEEEEECCCCEEEEEECCCCEEEEEECCCEECCCCCEECHHHHHHHHHHHHHHEEE
GISGIDYDGSLLDFDYHEVRVKQAIIENSRSVYLAVDHSKFGRNAMVKLGNISQINMLIT
EECCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCEEEEEEEE
NEQPPEEITAILKEQQIPCVVAGE
CCCCHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8955387; 3045764; 9278503 [H]