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The map label for this gene is uraA [H]

Identifier: 37680697

GI number: 37680697

Start: 2543179

End: 2544432

Strand: Direct

Name: uraA [H]

Synonym: VV2513

Alternate gene names: 37680697

Gene position: 2543179-2544432 (Clockwise)

Preceding gene: 37680695

Following gene: 37680699

Centisome position: 75.81

GC content: 48.48

Gene sequence:

>1254_bases
ATGAAAAATGCTTTACAGGGTGCACAAATGTTATTTGTCGCATTCGGTGCCTTGGTACTTGTACCTTTGCTGACCGGATT
GGACCCTAACGTCGCTTTATTTGGTGCAGGTGTCGGCACCTTATTGTTCCAATTGATCACCAAACGAAGCGTTCCCATTT
TTCTAGCCTCCTCTTTCGCTTTTATTGCGCCAATCATGTTTGGTATTCAAACTTGGGGTATTGGCGCAACCATGGGTGGC
TTAATGGCGGCAGGTTTGGTTTACGTTGCACTTGGCGCGATGATCAAAGTACGTGGCGTGGGCTTCATTCACAAAATTTT
ACCACCTGTCGTTGTTGGCCCTGTGATCATGGTTATCGGCCTTGGTCTTGCGCCAACGGCGGTCAACATGGCGGTAGGGA
AAACTGGTGATGGTGCGGTTCAACTCGTCAATGGTGATGCAGCAATCATCATCTCCGCAGTTTCACTCTTCACGACGATT
GCGCTGAGCGTATTTGCAAAAGGTTTCCTAAAGCTGGTTCCTATCGTCGGCGGTATCTTGGCAGGTTACTCGGTTTCACT
ATTCTACGGAGTGGTTGACTTTACACCGGTGGCTCAAGCCGCTTGGCTGGCCATGCCAAACTTCACCACCCCTGAGTTCA
ACATCAACGCGATTCTATTCATGATCCCTGTTGCAATCGCTCCTGCCGTTGAGCACGTAGGTGACATGTTGGCTATCTCG
AACGTCACAGGTAAAAACTACCTGAAAAAACCAGGACTACACCGCACGATTGCTGGTGACGGGGTTGCGACCATTGCCGC
ATCGATGGTTGGTGCACCACCAAACACAACCTACAGTGAAGTTACTGGCGCAGTGATGCTCACCAAAGCTTACAACCCAG
TCATCATGACATGGGCTGCCATCACCGCTATTGTTCTTGCACTTGTCGGTAAATTAGGCGCTACCCTACAAACCATTCCT
GTTCCTGTAATGGGCGGCATTATGATTCTTCTCTTTGGTTCGATTGCCACTGTAGGTCTTAATACGTTAATCAAGAATCA
CGTGGATCTGCATAAATCTCGCAATCTTGTGATTGTCGCGGTGACATTGGTGTTTGGTATTGGCGGTATGGCTTTTGGTA
TTGGCGAGTTCAGCCTACAGGGCGTGAGTCTATGTGGTATCGTGGCGATTATTCTTAACCTTATCCTGCCGCATGACATG
GGTGAAAACCACGTAGTGGATAACGCTCAGATGGAAGAAGAAGCACAAAACTAA

Upstream 100 bases:

>100_bases
CAGCAATCTTGCAAAAAATTGATCAAAAATACTTAGCAATCGTTTGCAAAGTGATAGAATCCCGCGAATTTATCTGCATA
GTTATTAATAGGGAGCCTTT

Downstream 100 bases:

>100_bases
TTGTTAAATGAAGCTAGGTTCGGTGATCCACACCTTAGTCGCCGAACATAAAGCAATCCGAATAAAAAAATGCCTGGTCA
GTGACCAGGCATTTTTTATT

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKNALQGAQMLFVAFGALVLVPLLTGLDPNVALFGAGVGTLLFQLITKRSVPIFLASSFAFIAPIMFGIQTWGIGATMGG
LMAAGLVYVALGAMIKVRGVGFIHKILPPVVVGPVIMVIGLGLAPTAVNMAVGKTGDGAVQLVNGDAAIIISAVSLFTTI
ALSVFAKGFLKLVPIVGGILAGYSVSLFYGVVDFTPVAQAAWLAMPNFTTPEFNINAILFMIPVAIAPAVEHVGDMLAIS
NVTGKNYLKKPGLHRTIAGDGVATIAASMVGAPPNTTYSEVTGAVMLTKAYNPVIMTWAAITAIVLALVGKLGATLQTIP
VPVMGGIMILLFGSIATVGLNTLIKNHVDLHKSRNLVIVAVTLVFGIGGMAFGIGEFSLQGVSLCGIVAIILNLILPHDM
GENHVVDNAQMEEEAQN

Sequences:

>Translated_417_residues
MKNALQGAQMLFVAFGALVLVPLLTGLDPNVALFGAGVGTLLFQLITKRSVPIFLASSFAFIAPIMFGIQTWGIGATMGG
LMAAGLVYVALGAMIKVRGVGFIHKILPPVVVGPVIMVIGLGLAPTAVNMAVGKTGDGAVQLVNGDAAIIISAVSLFTTI
ALSVFAKGFLKLVPIVGGILAGYSVSLFYGVVDFTPVAQAAWLAMPNFTTPEFNINAILFMIPVAIAPAVEHVGDMLAIS
NVTGKNYLKKPGLHRTIAGDGVATIAASMVGAPPNTTYSEVTGAVMLTKAYNPVIMTWAAITAIVLALVGKLGATLQTIP
VPVMGGIMILLFGSIATVGLNTLIKNHVDLHKSRNLVIVAVTLVFGIGGMAFGIGEFSLQGVSLCGIVAIILNLILPHDM
GENHVVDNAQMEEEAQN
>Mature_417_residues
MKNALQGAQMLFVAFGALVLVPLLTGLDPNVALFGAGVGTLLFQLITKRSVPIFLASSFAFIAPIMFGIQTWGIGATMGG
LMAAGLVYVALGAMIKVRGVGFIHKILPPVVVGPVIMVIGLGLAPTAVNMAVGKTGDGAVQLVNGDAAIIISAVSLFTTI
ALSVFAKGFLKLVPIVGGILAGYSVSLFYGVVDFTPVAQAAWLAMPNFTTPEFNINAILFMIPVAIAPAVEHVGDMLAIS
NVTGKNYLKKPGLHRTIAGDGVATIAASMVGAPPNTTYSEVTGAVMLTKAYNPVIMTWAAITAIVLALVGKLGATLQTIP
VPVMGGIMILLFGSIATVGLNTLIKNHVDLHKSRNLVIVAVTLVFGIGGMAFGIGEFSLQGVSLCGIVAIILNLILPHDM
GENHVVDNAQMEEEAQN

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=385, Percent_Identity=23.6363636363636, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI44680143, Length=290, Percent_Identity=25.1724137931034, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI44680148, Length=438, Percent_Identity=23.2876712328767, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40316845, Length=438, Percent_Identity=23.2876712328767, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788843, Length=393, Percent_Identity=39.6946564885496, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI87081818, Length=416, Percent_Identity=37.7403846153846, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI87082181, Length=377, Percent_Identity=27.8514588859416, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790087, Length=364, Percent_Identity=25.8241758241758, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082178, Length=339, Percent_Identity=25.9587020648968, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=331, Percent_Identity=25.0755287009063, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=173, Percent_Identity=27.1676300578035, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356175, Length=173, Percent_Identity=31.2138728323699, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43052; Mature: 43052

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNALQGAQMLFVAFGALVLVPLLTGLDPNVALFGAGVGTLLFQLITKRSVPIFLASSFA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCEEEHHHHH
FIAPIMFGIQTWGIGATMGGLMAAGLVYVALGAMIKVRGVGFIHKILPPVVVGPVIMVIG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LGLAPTAVNMAVGKTGDGAVQLVNGDAAIIISAVSLFTTIALSVFAKGFLKLVPIVGGIL
CCCCCHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYSVSLFYGVVDFTPVAQAAWLAMPNFTTPEFNINAILFMIPVAIAPAVEHVGDMLAIS
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NVTGKNYLKKPGLHRTIAGDGVATIAASMVGAPPNTTYSEVTGAVMLTKAYNPVIMTWAA
CCCCCHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHEEEEECCCCHHHHHHH
ITAIVLALVGKLGATLQTIPVPVMGGIMILLFGSIATVGLNTLIKNHVDLHKSRNLVIVA
HHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEH
VTLVFGIGGMAFGIGEFSLQGVSLCGIVAIILNLILPHDMGENHVVDNAQMEEEAQN
HHHHHHCCHHHHCCCHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MKNALQGAQMLFVAFGALVLVPLLTGLDPNVALFGAGVGTLLFQLITKRSVPIFLASSFA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCEEEHHHHH
FIAPIMFGIQTWGIGATMGGLMAAGLVYVALGAMIKVRGVGFIHKILPPVVVGPVIMVIG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LGLAPTAVNMAVGKTGDGAVQLVNGDAAIIISAVSLFTTIALSVFAKGFLKLVPIVGGIL
CCCCCHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYSVSLFYGVVDFTPVAQAAWLAMPNFTTPEFNINAILFMIPVAIAPAVEHVGDMLAIS
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NVTGKNYLKKPGLHRTIAGDGVATIAASMVGAPPNTTYSEVTGAVMLTKAYNPVIMTWAA
CCCCCHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHEEEEECCCCHHHHHHH
ITAIVLALVGKLGATLQTIPVPVMGGIMILLFGSIATVGLNTLIKNHVDLHKSRNLVIVA
HHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEH
VTLVFGIGGMAFGIGEFSLQGVSLCGIVAIILNLILPHDMGENHVVDNAQMEEEAQN
HHHHHHCCHHHHCCCHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]