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The map label for this gene is sdaC [H]

Identifier: 37680268

GI number: 37680268

Start: 2090061

End: 2091314

Strand: Direct

Name: sdaC [H]

Synonym: VV2084

Alternate gene names: 37680268

Gene position: 2090061-2091314 (Clockwise)

Preceding gene: 37680267

Following gene: 37680269

Centisome position: 62.31

GC content: 45.77

Gene sequence:

>1254_bases
ATGAAAACAACTTCAACTACGGCTCCTGCCGTACAATCTTCTAGTAAGTTTACTTACAAAGATTTCACTTGGTGTCTGTC
CCTTTTCGGTACAGCGGTAGGTGCTGGTGTACTTTTCCTTCCAATTAAAGCGGGTGCTGGCGGCTTCTGGCCATTAGTTA
TGCTAGCGCTACTTGCAGCACCAATGACTTGGTTCGCTCACAAATCTCTCGCTCGTTTCGTTCTTTCTGCTAAGAACCCT
GAAGCGGACATCACTGACACTGTAGAAGAGCACTTTGGTAAGACTGGCGCAAACCTTATTACTTTTGCCTATTTCTTCGC
TATCTACCCAATCGTTCTGATTTACGGTGTTGGTATCACAAACACAGTAGACTCTTTCCTTGTTAACCAAATGGGTATGG
AATCCATTCCACGTCCACTGCTATCTGGCGCATTGATCCTTGCAATGACCGCTGGTGTGGTATTTGGTAAAGAACTGATG
CTAAAAGCAACGTCTGCAATGGTTTACCCACTTGTATTTGTACTGCTTGCACTTTCTTTCTACCTGATCCCAGATTGGAA
CACGTCAATGATGCAAGTAGCACCTGATTGGTCTTCTATGCCTGTTGTCGTATGGCTAGCCATCCCGATCATCGTGTTCT
CATTCAACCACAGCCCAATCATCTCTCAGTTCTCTAAAGAACAGCGCCTACAGCATGGTGACAAAGCGGTTCAGAAAACC
GATGCGATCACTGGCGGTGCAGCGATGATGCTAATGGGCTTTGTTATGTTCTTCGTTTTCTCTGTTGTACTGTCTATGTC
TCCAGAGCAACTGGCTTCTGCGAAAGAGCAAAACATCTCTGTACTTTCTTACCTAGCGAACGTGCATGAGTCTCCACTGA
TCTCTTACCTTGGTCCACTGGTTGCGTTTGCAGCGATCACTTCTAGCTACTTCGGTCACTTCCTTGGTGCGCATGAAGGT
CTAGTTGGTCTGATCAAATCTCGCTCAAACAGCCCTATCAGCAAGATCGAGAAAGCGTCGCTACTGTTCATCGTTATCAC
TACTTGGATCGTGGCTATCGTTAACCCAAGTATCCTAGGCATGATTGAAACAATGGGCGCACCAATGATTGCGGCAATCC
TGTTCCTAATGCCTGTATTTGCAATGCAAAAAGTGCCAGCGATGGCGAAGTACAAAACTTCAGCAGCTGTGCAGATTTTC
ACAGTTATCTGTGGTCTTGCTTCTATTACTTCTGTAATCTACGGCGCTCTTTAA

Upstream 100 bases:

>100_bases
TAAGCACGAGCAATACATGATTTAGATCTAATTTTCTTGCAACAAAAAAGTGCAGAATTGCGGCCGACTTATTTCCTGTT
CCCAAAATGAGTAATCAAAA

Downstream 100 bases:

>100_bases
TCTCACTCCCCCTGTAAGATGAGAATAAAGACAAAAGCATAACGATAAGATAAAGCCTCCCTCCTCCTTGGGAGGCTTAC
TTTTGAGGTAATCAAAATGA

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKTTSTTAPAVQSSSKFTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVMLALLAAPMTWFAHKSLARFVLSAKNP
EADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGITNTVDSFLVNQMGMESIPRPLLSGALILAMTAGVVFGKELM
LKATSAMVYPLVFVLLALSFYLIPDWNTSMMQVAPDWSSMPVVVWLAIPIIVFSFNHSPIISQFSKEQRLQHGDKAVQKT
DAITGGAAMMLMGFVMFFVFSVVLSMSPEQLASAKEQNISVLSYLANVHESPLISYLGPLVAFAAITSSYFGHFLGAHEG
LVGLIKSRSNSPISKIEKASLLFIVITTWIVAIVNPSILGMIETMGAPMIAAILFLMPVFAMQKVPAMAKYKTSAAVQIF
TVICGLASITSVIYGAL

Sequences:

>Translated_417_residues
MKTTSTTAPAVQSSSKFTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVMLALLAAPMTWFAHKSLARFVLSAKNP
EADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGITNTVDSFLVNQMGMESIPRPLLSGALILAMTAGVVFGKELM
LKATSAMVYPLVFVLLALSFYLIPDWNTSMMQVAPDWSSMPVVVWLAIPIIVFSFNHSPIISQFSKEQRLQHGDKAVQKT
DAITGGAAMMLMGFVMFFVFSVVLSMSPEQLASAKEQNISVLSYLANVHESPLISYLGPLVAFAAITSSYFGHFLGAHEG
LVGLIKSRSNSPISKIEKASLLFIVITTWIVAIVNPSILGMIETMGAPMIAAILFLMPVFAMQKVPAMAKYKTSAAVQIF
TVICGLASITSVIYGAL
>Mature_417_residues
MKTTSTTAPAVQSSSKFTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVMLALLAAPMTWFAHKSLARFVLSAKNP
EADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGITNTVDSFLVNQMGMESIPRPLLSGALILAMTAGVVFGKELM
LKATSAMVYPLVFVLLALSFYLIPDWNTSMMQVAPDWSSMPVVVWLAIPIIVFSFNHSPIISQFSKEQRLQHGDKAVQKT
DAITGGAAMMLMGFVMFFVFSVVLSMSPEQLASAKEQNISVLSYLANVHESPLISYLGPLVAFAAITSSYFGHFLGAHEG
LVGLIKSRSNSPISKIEKASLLFIVITTWIVAIVNPSILGMIETMGAPMIAAILFLMPVFAMQKVPAMAKYKTSAAVQIF
TVICGLASITSVIYGAL

Specific function: Involved in the import of serine into the cell [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=426, Percent_Identity=51.8779342723005, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=41.3092550790068, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1789211, Length=405, Percent_Identity=33.0864197530864, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1789961, Length=390, Percent_Identity=27.4358974358974, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI145693183, Length=399, Percent_Identity=24.0601503759398, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44968; Mature: 44968

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTSTTAPAVQSSSKFTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVMLALLAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
PMTWFAHKSLARFVLSAKNPEADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGIT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
NTVDSFLVNQMGMESIPRPLLSGALILAMTAGVVFGKELMLKATSAMVYPLVFVLLALSF
HHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIPDWNTSMMQVAPDWSSMPVVVWLAIPIIVFSFNHSPIISQFSKEQRLQHGDKAVQKT
HCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DAITGGAAMMLMGFVMFFVFSVVLSMSPEQLASAKEQNISVLSYLANVHESPLISYLGPL
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VAFAAITSSYFGHFLGAHEGLVGLIKSRSNSPISKIEKASLLFIVITTWIVAIVNPSILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH
MIETMGAPMIAAILFLMPVFAMQKVPAMAKYKTSAAVQIFTVICGLASITSVIYGAL
HHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTTSTTAPAVQSSSKFTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVMLALLAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
PMTWFAHKSLARFVLSAKNPEADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGIT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
NTVDSFLVNQMGMESIPRPLLSGALILAMTAGVVFGKELMLKATSAMVYPLVFVLLALSF
HHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIPDWNTSMMQVAPDWSSMPVVVWLAIPIIVFSFNHSPIISQFSKEQRLQHGDKAVQKT
HCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DAITGGAAMMLMGFVMFFVFSVVLSMSPEQLASAKEQNISVLSYLANVHESPLISYLGPL
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VAFAAITSSYFGHFLGAHEGLVGLIKSRSNSPISKIEKASLLFIVITTWIVAIVNPSILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH
MIETMGAPMIAAILFLMPVFAMQKVPAMAKYKTSAAVQIFTVICGLASITSVIYGAL
HHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]