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The map label for this gene is speB [H]

Identifier: 37680171

GI number: 37680171

Start: 1985128

End: 1986063

Strand: Direct

Name: speB [H]

Synonym: VV1987

Alternate gene names: 37680171

Gene position: 1985128-1986063 (Clockwise)

Preceding gene: 37680170

Following gene: 37680172

Centisome position: 59.18

GC content: 49.15

Gene sequence:

>936_bases
ATGAATGATTTGTTTACTAAAACTGATTATTCACTCTACTCAAACTCGATGAGTTTTGTGCGTCGTCCGTATGTCAAAGA
TCCTGTCGCAGCAGACGCTGACCTCGTTGTTTTTGGTGCACCGCTAGACATGGCAACCTCTGGTCGTCCTGGCGCGCGTA
TGGGCCCAGATGCGATCCGTCGTGCATCGGTGAATCTTGCATGGGAAGGTAAGAAATTCCCTTGGGATTTCAACCTATTC
AAAAAAGTGAAAGTGATTGACGGTGGCGATCTTGTCTTCGATTGTGGTGATGCAGAAGACTTCACTTACCGTATGGAAGC
AGCGACCTCTGCGATCCTAAAAAGTGGCAAAACAATGCTTGGCCTTGGTGGTGATCACTTCATCACGCTGCCTATTCTGC
GCGCTTACGCAAAACACTACGGTGAAATGGCACTGATCCACTTCGATGCGCACACCGACACGTACGCAAACGGCAGCAGC
TATGACCACGGCACCATGTTCTACCACGCGCCAAAAGAAGGGCTTATCTCTCCTAAGCATTCAGTACAAGTCGGTATCCG
TACTGAGTACAAGCAAGAAGGTCACGGCTTTAACGTCATCAATGCGATGCAAGCCAACGACATGAGCGTAGAAGAGATCC
TTGCAGATATCCGCCGCATCGTGGCAGATAAGCCGGTGTATGTGACGTTTGATATCGACTGTCTCGATCCGGCTTTTGCA
CCAGGAACTGGTACACCTGTCTGCGGTGGCTTGAACTCGGACAAGATTTTGAAAATCATCCGTGGCCTAAAAGACGTTAA
CATCGTTGGTATGGATGTGGTGGAAGTCTCTCCTCCATACGATCAAAGCGATTTGACTGCACTGGCTGGCGCAACCATCG
CGCTGGAACTGATGTACGCTTGGGCAGCGAATAAAGAGTTTGAATCAGAGTTCTAA

Upstream 100 bases:

>100_bases
CTCTTTGGTATCGCAGCGCGTTGACCAAGAGGAACAGCAACAGATTCTAGCAGAGCTTGAACAAGGTCTGTCTGGTTACA
CCTATTTAGAGGATTTCTAA

Downstream 100 bases:

>100_bases
GCCAAAACTTTGAAGCAAGACAACCAAATCCGATAAACTCTGTTTATCGGATTTTTTATGCTTACTTTCCATGTTCCCCA
CTAACAACCCTAAGGCTATT

Product: agmatinase

Products: NA

Alternate protein names: Agmatine ureohydrolase; AUH [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNDLFTKTDYSLYSNSMSFVRRPYVKDPVAADADLVVFGAPLDMATSGRPGARMGPDAIRRASVNLAWEGKKFPWDFNLF
KKVKVIDGGDLVFDCGDAEDFTYRMEAATSAILKSGKTMLGLGGDHFITLPILRAYAKHYGEMALIHFDAHTDTYANGSS
YDHGTMFYHAPKEGLISPKHSVQVGIRTEYKQEGHGFNVINAMQANDMSVEEILADIRRIVADKPVYVTFDIDCLDPAFA
PGTGTPVCGGLNSDKILKIIRGLKDVNIVGMDVVEVSPPYDQSDLTALAGATIALELMYAWAANKEFESEF

Sequences:

>Translated_311_residues
MNDLFTKTDYSLYSNSMSFVRRPYVKDPVAADADLVVFGAPLDMATSGRPGARMGPDAIRRASVNLAWEGKKFPWDFNLF
KKVKVIDGGDLVFDCGDAEDFTYRMEAATSAILKSGKTMLGLGGDHFITLPILRAYAKHYGEMALIHFDAHTDTYANGSS
YDHGTMFYHAPKEGLISPKHSVQVGIRTEYKQEGHGFNVINAMQANDMSVEEILADIRRIVADKPVYVTFDIDCLDPAFA
PGTGTPVCGGLNSDKILKIIRGLKDVNIVGMDVVEVSPPYDQSDLTALAGATIALELMYAWAANKEFESEF
>Mature_311_residues
MNDLFTKTDYSLYSNSMSFVRRPYVKDPVAADADLVVFGAPLDMATSGRPGARMGPDAIRRASVNLAWEGKKFPWDFNLF
KKVKVIDGGDLVFDCGDAEDFTYRMEAATSAILKSGKTMLGLGGDHFITLPILRAYAKHYGEMALIHFDAHTDTYANGSS
YDHGTMFYHAPKEGLISPKHSVQVGIRTEYKQEGHGFNVINAMQANDMSVEEILADIRRIVADKPVYVTFDIDCLDPAFA
PGTGTPVCGGLNSDKILKIIRGLKDVNIVGMDVVEVSPPYDQSDLTALAGATIALELMYAWAANKEFESEF

Specific function: Catalyzes the formation of putrescine from agmatine [H]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family. Agmatinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI37537722, Length=294, Percent_Identity=42.1768707482993, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI10947139, Length=308, Percent_Identity=24.025974025974, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4502215, Length=296, Percent_Identity=22.972972972973, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789306, Length=305, Percent_Identity=60.327868852459, Blast_Score=381, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6325146, Length=240, Percent_Identity=25.4166666666667, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005925
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.11 [H]

Molecular weight: Translated: 34146; Mature: 34146

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00147 ARGINASE_1 ; PS00148 ARGINASE_2 ; PS01053 ARGINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLFTKTDYSLYSNSMSFVRRPYVKDPVAADADLVVFGAPLDMATSGRPGARMGPDAIR
CCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHH
RASVNLAWEGKKFPWDFNLFKKVKVIDGGDLVFDCGDAEDFTYRMEAATSAILKSGKTML
HCCEEEEECCCCCCCCCCCEEEEEEEECCCEEEECCCCCCEEEHHHHHHHHHHHCCCEEE
GLGGDHFITLPILRAYAKHYGEMALIHFDAHTDTYANGSSYDHGTMFYHAPKEGLISPKH
ECCCCCEEHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
SVQVGIRTEYKQEGHGFNVINAMQANDMSVEEILADIRRIVADKPVYVTFDIDCLDPAFA
EEEEEEEECHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCC
PGTGTPVCGGLNSDKILKIIRGLKDVNIVGMDVVEVSPPYDQSDLTALAGATIALELMYA
CCCCCCEECCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
WAANKEFESEF
HHCCCCCCCCC
>Mature Secondary Structure
MNDLFTKTDYSLYSNSMSFVRRPYVKDPVAADADLVVFGAPLDMATSGRPGARMGPDAIR
CCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHH
RASVNLAWEGKKFPWDFNLFKKVKVIDGGDLVFDCGDAEDFTYRMEAATSAILKSGKTML
HCCEEEEECCCCCCCCCCCEEEEEEEECCCEEEECCCCCCEEEHHHHHHHHHHHCCCEEE
GLGGDHFITLPILRAYAKHYGEMALIHFDAHTDTYANGSSYDHGTMFYHAPKEGLISPKH
ECCCCCEEHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
SVQVGIRTEYKQEGHGFNVINAMQANDMSVEEILADIRRIVADKPVYVTFDIDCLDPAFA
EEEEEEEECHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCC
PGTGTPVCGGLNSDKILKIIRGLKDVNIVGMDVVEVSPPYDQSDLTALAGATIALELMYA
CCCCCCEECCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
WAANKEFESEF
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA