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The map label for this gene is hutH

Identifier: 37680136

GI number: 37680136

Start: 1941231

End: 1942772

Strand: Direct

Name: hutH

Synonym: VV1952

Alternate gene names: 37680136

Gene position: 1941231-1942772 (Clockwise)

Preceding gene: 37680135

Following gene: 37680137

Centisome position: 57.87

GC content: 51.49

Gene sequence:

>1542_bases
ATGGATATGTTAAATCTCACGCTAAAGCCCGGTTGTCTTAGCTTAAATCAACTGCGTCAAGTCAGTCGTTCGCCCATCAA
CCTTTCCCTTGATGCGTCAGCGATTCCAGCTATTGAAGATAGCACGCAAGTGGTTGAACGAGTCATCGCCGAGGATCGCA
CCGTTTACGGCATTAATACTGGATTTGGCTTATTGGCCAATACACGCATTGCCCCAGAAGATCTTGAAACGCTGCAACGC
AGTATCGTCCTTTCTCACGCAGCGGGTATCGGCGAGTTCATGGCAGATGAAACGGTCCGTCTGATGATGGTGCTCAAAAT
CAATAGCCTATCCCGTGGATATTCCGGTATTCGTCTCAACGTCATTCAAATGCTGATCGATTTGGTCAACGCGCAAGTTT
ACCCTTGCGTACCACAAAAAGGCTCGGTTGGGGCATCGGGCGACTTGGCCCCACTGGCTCATATGAGCACAGTGTTACTG
GGTGAAGGGCAAGCACGTCACAACGGCAAAATTATCTCAGGCCTAGAAGCCCTCAAAATTGCTGGCCTTGAACCGATCAC
GCTTGCGCCAAAAGAAGGTCTGGCACTACTGAATGGCACGCAGGCGTCGACGGCTTTCGCGTTGGAAGGTCTGTTTATTG
CTGAAGATCTCTTCGCATCCGCCACCGTCTGCGGCGCAATGTCAGTCGAAGCCGCACTAGGGAGTCGCCGTCCTTTTGAC
CCGCGTATTCATCGCGTGCGCGGACACCGTAGCCAAATGGATTCTGCGATGGCCTATCGTCACCTGCTGGACACCAGTAG
TGAAATTGGCCAGTCACACAGCAACTGTGAAAAGGTGCAAGACCCTTACTCGTTGCGTTGCCAGCCACAAGTGATGGGCG
CATGTCTGCAGCAGATCCGTAACTCAGCAGAGATCTTATTGGTTGAGTCGAACTCGGTTTCCGACAATCCCCTCGTATTT
GCTGAAGATGACGACATTATTTCTGGTGGTAACTTTCACGCGGAGCCTGTTGCTATGGCAGCAGACAACCTTGCTCTCGC
GATTGCAGAAATCGGTAGCCTCTCGGAGCGCCGCATGGCATTGCTGATTGATAGCGCACTCTCTAAGTTACCACCATTTT
TGGTCGATAACGGCGGAGTCAACTCTGGTTTTATGATTGCGCAAGTAACCTCGGCGGCGTTGGCAAGTGAAAACAAAACT
CTTGCACATCCCGCATCCGTGGACAGCTTACCCACGTCAGCCAACCAAGAAGATCATGTCTCCATGGCTACCTTTGCCGC
CCGTCGTTTACGTGAAATGGGTGAAAACACACGTGGCATCTTAGCCGTCGAGTATCTCTCAGCGGCGCAAGGACTGGATT
TCCGTGCACCGCATAAATCCTCGCCTCGCATAGAACAAGCAAAGCAGATGCTACGAGAGAAAGTCAGTTTCTACGATAAA
GACCGTTACTTTGCTCCGGATATTGAAAAAGCCAACTCACTGCTGAAGCTGGCCGTGCACAACGTGCTGATGCCAGAAGC
GCTGTTACCGAGTGTTCTCTAA

Upstream 100 bases:

>100_bases
ACGCCGATGCGGGTTACGACATCGCCAAACAGTGCGCAGCGCAACAAGGTCTTGACCTACCGATGCTGAACGAAGAATTG
AGCAAGTTGAAGTAAGGAAT

Downstream 100 bases:

>100_bases
TCACGGATAAGCCAACCATAACCACAAGAGGGCATAATGTGCCCTCTTATCTCTTATTTCCAGATGTAAACCGTTCACTT
TGCACCCAAATCTGTGAGCA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MDMLNLTLKPGCLSLNQLRQVSRSPINLSLDASAIPAIEDSTQVVERVIAEDRTVYGINTGFGLLANTRIAPEDLETLQR
SIVLSHAAGIGEFMADETVRLMMVLKINSLSRGYSGIRLNVIQMLIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLL
GEGQARHNGKIISGLEALKIAGLEPITLAPKEGLALLNGTQASTAFALEGLFIAEDLFASATVCGAMSVEAALGSRRPFD
PRIHRVRGHRSQMDSAMAYRHLLDTSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRNSAEILLVESNSVSDNPLVF
AEDDDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKT
LAHPASVDSLPTSANQEDHVSMATFAARRLREMGENTRGILAVEYLSAAQGLDFRAPHKSSPRIEQAKQMLREKVSFYDK
DRYFAPDIEKANSLLKLAVHNVLMPEALLPSVL

Sequences:

>Translated_513_residues
MDMLNLTLKPGCLSLNQLRQVSRSPINLSLDASAIPAIEDSTQVVERVIAEDRTVYGINTGFGLLANTRIAPEDLETLQR
SIVLSHAAGIGEFMADETVRLMMVLKINSLSRGYSGIRLNVIQMLIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLL
GEGQARHNGKIISGLEALKIAGLEPITLAPKEGLALLNGTQASTAFALEGLFIAEDLFASATVCGAMSVEAALGSRRPFD
PRIHRVRGHRSQMDSAMAYRHLLDTSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRNSAEILLVESNSVSDNPLVF
AEDDDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKT
LAHPASVDSLPTSANQEDHVSMATFAARRLREMGENTRGILAVEYLSAAQGLDFRAPHKSSPRIEQAKQMLREKVSFYDK
DRYFAPDIEKANSLLKLAVHNVLMPEALLPSVL
>Mature_513_residues
MDMLNLTLKPGCLSLNQLRQVSRSPINLSLDASAIPAIEDSTQVVERVIAEDRTVYGINTGFGLLANTRIAPEDLETLQR
SIVLSHAAGIGEFMADETVRLMMVLKINSLSRGYSGIRLNVIQMLIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLL
GEGQARHNGKIISGLEALKIAGLEPITLAPKEGLALLNGTQASTAFALEGLFIAEDLFASATVCGAMSVEAALGSRRPFD
PRIHRVRGHRSQMDSAMAYRHLLDTSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRNSAEILLVESNSVSDNPLVF
AEDDDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKT
LAHPASVDSLPTSANQEDHVSMATFAARRLREMGENTRGILAVEYLSAAQGLDFRAPHKSSPRIEQAKQMLREKVSFYDK
DRYFAPDIEKANSLLKLAVHNVLMPEALLPSVL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=487, Percent_Identity=43.9425051334702, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=492, Percent_Identity=44.3089430894309, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55159; Mature: 55159

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMLNLTLKPGCLSLNQLRQVSRSPINLSLDASAIPAIEDSTQVVERVIAEDRTVYGINT
CCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEECC
GFGLLANTRIAPEDLETLQRSIVLSHAAGIGEFMADETVRLMMVLKINSLSRGYSGIRLN
CCCHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHEEEEEEEEEHHHCCCCCCHHHH
VIQMLIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLLGEGQARHNGKIISGLEALKI
HHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AGLEPITLAPKEGLALLNGTQASTAFALEGLFIAEDLFASATVCGAMSVEAALGSRRPFD
CCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PRIHRVRGHRSQMDSAMAYRHLLDTSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIR
HHHHHHHCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHC
NSAEILLVESNSVSDNPLVFAEDDDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMA
CCCEEEEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHCCCCHHHHH
LLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKTLAHPASVDSLPTSANQEDHV
HHHHHHHHHCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRLREMGENTRGILAVEYLSAAQGLDFRAPHKSSPRIEQAKQMLREKVSFYDK
HHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
DRYFAPDIEKANSLLKLAVHNVLMPEALLPSVL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MDMLNLTLKPGCLSLNQLRQVSRSPINLSLDASAIPAIEDSTQVVERVIAEDRTVYGINT
CCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEECC
GFGLLANTRIAPEDLETLQRSIVLSHAAGIGEFMADETVRLMMVLKINSLSRGYSGIRLN
CCCHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHEEEEEEEEEHHHCCCCCCHHHH
VIQMLIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLLGEGQARHNGKIISGLEALKI
HHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AGLEPITLAPKEGLALLNGTQASTAFALEGLFIAEDLFASATVCGAMSVEAALGSRRPFD
CCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PRIHRVRGHRSQMDSAMAYRHLLDTSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIR
HHHHHHHCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHC
NSAEILLVESNSVSDNPLVFAEDDDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMA
CCCEEEEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHCCCCHHHHH
LLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKTLAHPASVDSLPTSANQEDHV
HHHHHHHHHCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRLREMGENTRGILAVEYLSAAQGLDFRAPHKSSPRIEQAKQMLREKVSFYDK
HHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
DRYFAPDIEKANSLLKLAVHNVLMPEALLPSVL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA