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The map label for this gene is lon [H]

Identifier: 37523700

GI number: 37523700

Start: 4327560

End: 4328588

Strand: Reverse

Name: lon [H]

Synonym: gll4131

Alternate gene names: 37523700

Gene position: 4328588-4327560 (Counterclockwise)

Preceding gene: 37523702

Following gene: 37523699

Centisome position: 92.91

GC content: 62.1

Gene sequence:

>1029_bases
GTGGCCGTTGCCGCTTTTGGAAGTTTTGCAGCGCAGGCCGCCGATCCTCCTCGAGCATTGCCTTTGGTAGTGTTGCCGGA
GGCTGTTCTTTTTCCGGGGCAGCCGCTCACCTTGAGCATCGTCCAGCCCCGCGACCGCAAGATGATGGGCGCGGTACTCA
ACGGCGACGGACGGCTGGGGGTCGTGCTTAAAACCAACGACAAACCCGCCGCGATCGGTTGCACGGCCGATATTCTCTAC
ATCGAGCAGCTCGGTGGCGGCGGTTTTAATATGCTTACCCAGGGCGGGCGGCGCTTCCGGGTCGGCTCCTATACCCAGCG
CGAGCCGTTTTTGCTGGCGGCGGTCGATTGGCTTGCCGAGGGACCGTCCGGCAAAGAGTTGGAGCCGCTGGTTATCGAGA
CTAAGCAACTGCTCCAGGACGTGGTGGGCCTCTCGAGCGAAGCGCTCAAGCGCACGGTGGACCTACCCAGACTGCCGAGC
GAACCCAGGGAATTTTCTTATTGGATGGCTAGTCGCTTCTACGGCGCTCCGAGGACGCAACAGATGCTTCTGGAGATCCC
CGATACGGCGGAGCGGCTGCAAAAAGCCAAAGCAATCCTGCTCAATACCCGCCAGGAATTGATCGCGAGCCTGCAGCGGC
AAAGCGGCCGTACCCGTGCCGCCGACACGCCCACCCCCGGCGAAGCCAAAATCGCCCTAGGCGGCAGCGATCCGATCTCC
TTTTCGATGCTCATCGGCAGTGACTTCCTGCAGGGGGTTGTGCTCAGCGACCGGCTGTTGCTCACCCGCCGCAAAGGTGG
TGCCGCCGAGGTCGGTACGCAGATCCGGCTCACCCCTGCCCAGCAGCAGCAATTTTTCAAGCTCTGGATCGCTTTTGTCA
AGGATGTCGAAGCGGGTGCCTACGCCCGGGCGGACAAAAAACCCGCCCAACCGTTGCCTCTCAACGGCTGGCTGAGAGAA
GTGATCTTTGCGAGCAGCACCCCGGACCGGGCCGAACTGCTCGCCGCTCTCCAGAAAACCCAACCCTGA

Upstream 100 bases:

>100_bases
GAGAAGGACAGATGTGCCGCAATGGCGTACATTGAATCCCAGAGGGGCCAATCGGAGACAACCGGCCATGGGTGTTCGCC
GCCGATTTATTCTGGGGGGT

Downstream 100 bases:

>100_bases
ATCAGCCTCTTTCTTGGGAGGGACAGCCACAGCCGCACTTCCCACCTGGGGAAGACGAAGCTCGCGCCACCCGAATGGGA
TGATATCGGGGTGTGCATTA

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAVAAFGSFAAQAADPPRALPLVVLPEAVLFPGQPLTLSIVQPRDRKMMGAVLNGDGRLGVVLKTNDKPAAIGCTADILY
IEQLGGGGFNMLTQGGRRFRVGSYTQREPFLLAAVDWLAEGPSGKELEPLVIETKQLLQDVVGLSSEALKRTVDLPRLPS
EPREFSYWMASRFYGAPRTQQMLLEIPDTAERLQKAKAILLNTRQELIASLQRQSGRTRAADTPTPGEAKIALGGSDPIS
FSMLIGSDFLQGVVLSDRLLLTRRKGGAAEVGTQIRLTPAQQQQFFKLWIAFVKDVEAGAYARADKKPAQPLPLNGWLRE
VIFASSTPDRAELLAALQKTQP

Sequences:

>Translated_342_residues
MAVAAFGSFAAQAADPPRALPLVVLPEAVLFPGQPLTLSIVQPRDRKMMGAVLNGDGRLGVVLKTNDKPAAIGCTADILY
IEQLGGGGFNMLTQGGRRFRVGSYTQREPFLLAAVDWLAEGPSGKELEPLVIETKQLLQDVVGLSSEALKRTVDLPRLPS
EPREFSYWMASRFYGAPRTQQMLLEIPDTAERLQKAKAILLNTRQELIASLQRQSGRTRAADTPTPGEAKIALGGSDPIS
FSMLIGSDFLQGVVLSDRLLLTRRKGGAAEVGTQIRLTPAQQQQFFKLWIAFVKDVEAGAYARADKKPAQPLPLNGWLRE
VIFASSTPDRAELLAALQKTQP
>Mature_341_residues
AVAAFGSFAAQAADPPRALPLVVLPEAVLFPGQPLTLSIVQPRDRKMMGAVLNGDGRLGVVLKTNDKPAAIGCTADILYI
EQLGGGGFNMLTQGGRRFRVGSYTQREPFLLAAVDWLAEGPSGKELEPLVIETKQLLQDVVGLSSEALKRTVDLPRLPSE
PREFSYWMASRFYGAPRTQQMLLEIPDTAERLQKAKAILLNTRQELIASLQRQSGRTRAADTPTPGEAKIALGGSDPISF
SMLIGSDFLQGVVLSDRLLLTRRKGGAAEVGTQIRLTPAQQQQFFKLWIAFVKDVEAGAYARADKKPAQPLPLNGWLREV
IFASSTPDRAELLAALQKTQP

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 37143; Mature: 37012

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAAFGSFAAQAADPPRALPLVVLPEAVLFPGQPLTLSIVQPRDRKMMGAVLNGDGRLG
CCEECCCHHHHHCCCCCCCCCEEEECHHHCCCCCCEEEEEECCCCHHHHHEEECCCCEEE
VVLKTNDKPAAIGCTADILYIEQLGGGGFNMLTQGGRRFRVGSYTQREPFLLAAVDWLAE
EEEECCCCCCEEECCEEEEEEEECCCCCHHHHHCCCCEEEECCCCCCCCEEEEEEHHHHC
GPSGKELEPLVIETKQLLQDVVGLSSEALKRTVDLPRLPSEPREFSYWMASRFYGAPRTQ
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCH
QMLLEIPDTAERLQKAKAILLNTRQELIASLQRQSGRTRAADTPTPGEAKIALGGSDPIS
HHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCE
FSMLIGSDFLQGVVLSDRLLLTRRKGGAAEVGTQIRLTPAQQQQFFKLWIAFVKDVEAGA
EEEEHHHHHHHHHHHCCEEEEEECCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
YARADKKPAQPLPLNGWLREVIFASSTPDRAELLAALQKTQP
EECCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVAAFGSFAAQAADPPRALPLVVLPEAVLFPGQPLTLSIVQPRDRKMMGAVLNGDGRLG
CEECCCHHHHHCCCCCCCCCEEEECHHHCCCCCCEEEEEECCCCHHHHHEEECCCCEEE
VVLKTNDKPAAIGCTADILYIEQLGGGGFNMLTQGGRRFRVGSYTQREPFLLAAVDWLAE
EEEECCCCCCEEECCEEEEEEEECCCCCHHHHHCCCCEEEECCCCCCCCEEEEEEHHHHC
GPSGKELEPLVIETKQLLQDVVGLSSEALKRTVDLPRLPSEPREFSYWMASRFYGAPRTQ
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCH
QMLLEIPDTAERLQKAKAILLNTRQELIASLQRQSGRTRAADTPTPGEAKIALGGSDPIS
HHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCE
FSMLIGSDFLQGVVLSDRLLLTRRKGGAAEVGTQIRLTPAQQQQFFKLWIAFVKDVEAGA
EEEEHHHHHHHHHHHCCEEEEEECCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
YARADKKPAQPLPLNGWLREVIFASSTPDRAELLAALQKTQP
EECCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA